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The map label for this gene is ribBA [H]

Identifier: 220931698

GI number: 220931698

Start: 919212

End: 920426

Strand: Direct

Name: ribBA [H]

Synonym: Hore_08550

Alternate gene names: 220931698

Gene position: 919212-920426 (Clockwise)

Preceding gene: 220931697

Following gene: 220931699

Centisome position: 35.65

GC content: 44.77

Gene sequence:

>1215_bases
GTGGATAAGATTGAGGGAGCCCTGGAAGAGCTTAAAGAGGGGAAAATGGTCATAGTAGTTGATGATGAAGACAGGGAGAA
TGAAGGGGACCTGGTAATGGTTGCGGAAAAAGTAAGCCTACAGGCTGTCAACTTTATGATAAAAGAGGCCAGGGGCCTGG
TCTGTGTTCCCATGGAGGAAGAGAGGTTGAAAAGGCTTTCAATCCCTCCCATGGTCACCTTTAATAATGATTTGAATGAA
ACAGCCTTTACTGTTTCGGTGGATCATAGAGAAACTACCACCGGTATTTCTGCCCATGAGAGGGCCCTTACGATTAAAAA
ATTGATAGATCCCGCCAGCACAGCTGAGGATTTCAGGAGGCCGGGCCATGTTTTTCCCCTTGCCGGGAAAAAGGGAGGGG
TATTAAAAAGGCCAGGCCATACCGAAGCTGCCATTGACCTGGCCAGACTGGCCGGCTGCCATGGGGCAGGAGTCATCTGT
GAGATAATTAATGATGATGGAACCATGGCCAGACTGGCAGATTTAGAGAGATTTGCCCATCACCATTGTTTAAAAATCAT
CAGTATAAGGGATTTGATTAAATACAGGATGAAAAAAGAAAAACTGGTCAAGAGGGTTGCTGAAGCCATGCTACCGACAG
TTTTCGGTTCATTCAAGATTATTGCCTATTTAGATGTTATAGATGAGAGGGAACACCTTGCACTCATTAAAGGTGATATA
CGGGGGAGAGAAAAGATTCTCGTAAGGGTGCATTCTGAATGCCTGACAGGGGATGTCCTTTCCTCTCTCCGCTGTGATTG
TGGGGAACAGTTGGCCCGTTCTTTAAAGATGATTGAAAGGGCTGGAGCAGGTGTCCTTTTATATATGCGCCAGGAGGGCA
GGGGGATAGGGCTCAGTAACAAGATTAAAGCCTATGCCCTGCAGGAACAGGGGCTGGATACAGTTGAGGCCAATGAGGTG
CTGGGTTATCCGGCTGATATGAGGGATTATGGCATGGCTGCCCAGATTCTGAAGGATTTAGGTTTGAATTCAATAAGGCT
GATAACAAATAATCCAGAAAAAATAAGAGGGCTTGAGGAGTATGGCCTTTCTGTAATAGAACGGATTCCTATAATAATAA
AAGCAAATGAGAAAAACAGGTTCTACCTGGAGGTAAAACAAAAGAGGATGGGACATTTGTTGAATATAATCTGTTCATTA
ACCTTATTACCTTAA

Upstream 100 bases:

>100_bases
TGAAAAATTATTTCGGGAATAAAGAGTTTGTACCCCATCATACAACTATAAACAGGGAATTTTTGATTGAAAATGGTTTT
ATCTGAAGGGGGTTTTAAGG

Downstream 100 bases:

>100_bases
TGTTCTTATATAATTATCTTACTTTCTTAAATTTGTTAATATCCTGATTTTTTATAGAAAGGAGTTAATTATTTATGAGA
AATGTTATTGAAGGCCAATT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDKIEGALEELKEGKMVIVVDDEDRENEGDLVMVAEKVSLQAVNFMIKEARGLVCVPMEEERLKRLSIPPMVTFNNDLNE
TAFTVSVDHRETTTGISAHERALTIKKLIDPASTAEDFRRPGHVFPLAGKKGGVLKRPGHTEAAIDLARLAGCHGAGVIC
EIINDDGTMARLADLERFAHHHCLKIISIRDLIKYRMKKEKLVKRVAEAMLPTVFGSFKIIAYLDVIDEREHLALIKGDI
RGREKILVRVHSECLTGDVLSSLRCDCGEQLARSLKMIERAGAGVLLYMRQEGRGIGLSNKIKAYALQEQGLDTVEANEV
LGYPADMRDYGMAAQILKDLGLNSIRLITNNPEKIRGLEEYGLSVIERIPIIIKANEKNRFYLEVKQKRMGHLLNIICSL
TLLP

Sequences:

>Translated_404_residues
MDKIEGALEELKEGKMVIVVDDEDRENEGDLVMVAEKVSLQAVNFMIKEARGLVCVPMEEERLKRLSIPPMVTFNNDLNE
TAFTVSVDHRETTTGISAHERALTIKKLIDPASTAEDFRRPGHVFPLAGKKGGVLKRPGHTEAAIDLARLAGCHGAGVIC
EIINDDGTMARLADLERFAHHHCLKIISIRDLIKYRMKKEKLVKRVAEAMLPTVFGSFKIIAYLDVIDEREHLALIKGDI
RGREKILVRVHSECLTGDVLSSLRCDCGEQLARSLKMIERAGAGVLLYMRQEGRGIGLSNKIKAYALQEQGLDTVEANEV
LGYPADMRDYGMAAQILKDLGLNSIRLITNNPEKIRGLEEYGLSVIERIPIIIKANEKNRFYLEVKQKRMGHLLNIICSL
TLLP
>Mature_404_residues
MDKIEGALEELKEGKMVIVVDDEDRENEGDLVMVAEKVSLQAVNFMIKEARGLVCVPMEEERLKRLSIPPMVTFNNDLNE
TAFTVSVDHRETTTGISAHERALTIKKLIDPASTAEDFRRPGHVFPLAGKKGGVLKRPGHTEAAIDLARLAGCHGAGVIC
EIINDDGTMARLADLERFAHHHCLKIISIRDLIKYRMKKEKLVKRVAEAMLPTVFGSFKIIAYLDVIDEREHLALIKGDI
RGREKILVRVHSECLTGDVLSSLRCDCGEQLARSLKMIERAGAGVLLYMRQEGRGIGLSNKIKAYALQEQGLDTVEANEV
LGYPADMRDYGMAAQILKDLGLNSIRLITNNPEKIRGLEEYGLSVIERIPIIIKANEKNRFYLEVKQKRMGHLLNIICSL
TLLP

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=54.9222797927461, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=45.5445544554455, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=44.1176470588235, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=45.6140350877193, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 45127; Mature: 45127

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIEGALEELKEGKMVIVVDDEDRENEGDLVMVAEKVSLQAVNFMIKEARGLVCVPMEE
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEECCCH
ERLKRLSIPPMVTFNNDLNETAFTVSVDHRETTTGISAHERALTIKKLIDPASTAEDFRR
HHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCC
PGHVFPLAGKKGGVLKRPGHTEAAIDLARLAGCHGAGVICEIINDDGTMARLADLERFAH
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHH
HHCLKIISIRDLIKYRMKKEKLVKRVAEAMLPTVFGSFKIIAYLDVIDEREHLALIKGDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCEEEEECCC
RGREKILVRVHSECLTGDVLSSLRCDCGEQLARSLKMIERAGAGVLLYMRQEGRGIGLSN
CCCHHHHEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
KIKAYALQEQGLDTVEANEVLGYPADMRDYGMAAQILKDLGLNSIRLITNNPEKIRGLEE
CHHEEEEHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCHHH
YGLSVIERIPIIIKANEKNRFYLEVKQKRMGHLLNIICSLTLLP
HHHHHHHHCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKIEGALEELKEGKMVIVVDDEDRENEGDLVMVAEKVSLQAVNFMIKEARGLVCVPMEE
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEECCCH
ERLKRLSIPPMVTFNNDLNETAFTVSVDHRETTTGISAHERALTIKKLIDPASTAEDFRR
HHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCC
PGHVFPLAGKKGGVLKRPGHTEAAIDLARLAGCHGAGVICEIINDDGTMARLADLERFAH
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHH
HHCLKIISIRDLIKYRMKKEKLVKRVAEAMLPTVFGSFKIIAYLDVIDEREHLALIKGDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCEEEEECCC
RGREKILVRVHSECLTGDVLSSLRCDCGEQLARSLKMIERAGAGVLLYMRQEGRGIGLSN
CCCHHHHEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
KIKAYALQEQGLDTVEANEVLGYPADMRDYGMAAQILKDLGLNSIRLITNNPEKIRGLEE
CHHEEEEHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCHHH
YGLSVIERIPIIIKANEKNRFYLEVKQKRMGHLLNIICSLTLLP
HHHHHHHHCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA