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The map label for this gene is hom [H]

Identifier: 220931646

GI number: 220931646

Start: 861481

End: 862767

Strand: Direct

Name: hom [H]

Synonym: Hore_08020

Alternate gene names: 220931646

Gene position: 861481-862767 (Clockwise)

Preceding gene: 220931645

Following gene: 220931647

Centisome position: 33.41

GC content: 39.78

Gene sequence:

>1287_bases
ATGATTAAAATAGGTTTACTGGGTCTGGGTACTGTCGGTAGTGGAGTTGTTACAATTATGGAGAACAATAAGGAGAGTAT
AAGGAGAAAAGTGGGGACCTCTCTAGCAATAGAGAAGGTTCTAGTTAAAAATCTTGACAAGGAAAGGGACCTGGATATTG
ATTCCAGGGTGTTGACCAGTAATATTGAAGATATAGTCTACAATCCTGATATTGATCTTGTTGTGGAATTAATTGGTGGT
GAAGAACCTGCCTGCCAGTATATTAAAGAGGCTATAAATAGGGGGAAGAGTGTTGTTACTGCCAATAAATTGGTTATAGC
CAAACATGGTACTGAGATCTTAAAACTGGCCCGGGAAAAAGGGGTTCAGGTCAGCTATGAGGGTAGTGTTGGTGGTGGAA
TTCCTATTATCAGGCCATTGAAGGAATCACTGGCGGCAAACCGGATTCATGAAATTTATGGTATTCTAAATGGTACCACC
AATTATATTCTAACTAAGATGACCAGAGAGGGGAGAAAATTTCAGGAAGTACTGGCTGAAGCCCAGAAACTAGGATATGC
TGAAAGTGATCCCTCTTCTGATATTGAAGGTTATGATGCTGCCTATAAAATAGCTATACTGGCCTCTATTGCCTTTGAAA
CATCTATTGACATCAGTTCGGTTTATGTAGAAGGTATTGATGGTATCAGTGTTGATGACATTGAACTTGCCCGGGAACTG
GGTTATGTTATAAAATTATTAGCTATAGGAAAAAGGTGTGAACGTGGTCTCGACATCAGGGTCCATCCCACCTTTATTCC
CAGAAGCCATCCTCTGGCCCTGGTAAGTGATGTTTATAACGCTGTTTATTTACATGGTGATGCAGTAGGGGATGTTATGT
CCTATGGTAAAGGGGCTGGACAGATGCCGACCGGTAGTGCTGTAGTTGCTGACATTATTCAGGTGGCAAGAGATATTCAT
TCTGGTAGAGTTGTGACCCCGTCCCTGGACACGACTATAAAACACAGGGTAGTTGATATAAATGAAATTGAGAATAGTTT
TTATCTGAGATTACAGGTTAGAGATAAGCCGGGAGTTTTAGCCCAGATTACTAAAGTTTTAGGTGATAATAAGGTAAGCC
TTGCTTCTGTCTTACAAAAGCATCGATTAACAACTGTAGTACCCCTGGTGTTAATAACCCATCCTGTTAAAGAGCAATTT
ATTAATAAGTCATTAAAGGAATTAAAGAAGATTGAAGATGTTGTTAGCATTGATAGTTTAATAAGGGTTGAGGAGGAATC
AATATGA

Upstream 100 bases:

>100_bases
TCATTATAACATAAACAGTAAATATATCGAAACAGGACTGGATAATAAGGGATTAATTTTAAAAGGACACAAGTTCAGTC
TGTCAGGAGGGAGCAGGTAG

Downstream 100 bases:

>100_bases
AAAAATGGCCTGGAATAATTGAAGCTTATAGAGAATTTATGCCCCTTAAGGAAACAACAAAACCGGTAACCCTGCAGGAG
GGAAATACCCCTTTAATATA

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIKIGLLGLGTVGSGVVTIMENNKESIRRKVGTSLAIEKVLVKNLDKERDLDIDSRVLTSNIEDIVYNPDIDLVVELIGG
EEPACQYIKEAINRGKSVVTANKLVIAKHGTEILKLAREKGVQVSYEGSVGGGIPIIRPLKESLAANRIHEIYGILNGTT
NYILTKMTREGRKFQEVLAEAQKLGYAESDPSSDIEGYDAAYKIAILASIAFETSIDISSVYVEGIDGISVDDIELAREL
GYVIKLLAIGKRCERGLDIRVHPTFIPRSHPLALVSDVYNAVYLHGDAVGDVMSYGKGAGQMPTGSAVVADIIQVARDIH
SGRVVTPSLDTTIKHRVVDINEIENSFYLRLQVRDKPGVLAQITKVLGDNKVSLASVLQKHRLTTVVPLVLITHPVKEQF
INKSLKELKKIEDVVSIDSLIRVEEESI

Sequences:

>Translated_428_residues
MIKIGLLGLGTVGSGVVTIMENNKESIRRKVGTSLAIEKVLVKNLDKERDLDIDSRVLTSNIEDIVYNPDIDLVVELIGG
EEPACQYIKEAINRGKSVVTANKLVIAKHGTEILKLAREKGVQVSYEGSVGGGIPIIRPLKESLAANRIHEIYGILNGTT
NYILTKMTREGRKFQEVLAEAQKLGYAESDPSSDIEGYDAAYKIAILASIAFETSIDISSVYVEGIDGISVDDIELAREL
GYVIKLLAIGKRCERGLDIRVHPTFIPRSHPLALVSDVYNAVYLHGDAVGDVMSYGKGAGQMPTGSAVVADIIQVARDIH
SGRVVTPSLDTTIKHRVVDINEIENSFYLRLQVRDKPGVLAQITKVLGDNKVSLASVLQKHRLTTVVPLVLITHPVKEQF
INKSLKELKKIEDVVSIDSLIRVEEESI
>Mature_428_residues
MIKIGLLGLGTVGSGVVTIMENNKESIRRKVGTSLAIEKVLVKNLDKERDLDIDSRVLTSNIEDIVYNPDIDLVVELIGG
EEPACQYIKEAINRGKSVVTANKLVIAKHGTEILKLAREKGVQVSYEGSVGGGIPIIRPLKESLAANRIHEIYGILNGTT
NYILTKMTREGRKFQEVLAEAQKLGYAESDPSSDIEGYDAAYKIAILASIAFETSIDISSVYVEGIDGISVDDIELAREL
GYVIKLLAIGKRCERGLDIRVHPTFIPRSHPLALVSDVYNAVYLHGDAVGDVMSYGKGAGQMPTGSAVVADIIQVARDIH
SGRVVTPSLDTTIKHRVVDINEIENSFYLRLQVRDKPGVLAQITKVLGDNKVSLASVLQKHRLTTVVPLVLITHPVKEQF
INKSLKELKKIEDVVSIDSLIRVEEESI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=26.0504201680672, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786183, Length=277, Percent_Identity=28.5198555956679, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46808; Mature: 46808

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIGLLGLGTVGSGVVTIMENNKESIRRKVGTSLAIEKVLVKNLDKERDLDIDSRVLTS
CEEEEEEECCCCCCCEEEEEECCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHHHHC
NIEDIVYNPDIDLVVELIGGEEPACQYIKEAINRGKSVVTANKLVIAKHGTEILKLAREK
CCHHEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECEEEEEECCHHHHHHHHHC
GVQVSYEGSVGGGIPIIRPLKESLAANRIHEIYGILNGTTNYILTKMTREGRKFQEVLAE
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
AQKLGYAESDPSSDIEGYDAAYKIAILASIAFETSIDISSVYVEGIDGISVDDIELAREL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHH
GYVIKLLAIGKRCERGLDIRVHPTFIPRSHPLALVSDVYNAVYLHGDAVGDVMSYGKGAG
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHEEECCCHHHHHHHCCCCCC
QMPTGSAVVADIIQVARDIHSGRVVTPSLDTTIKHRVVDINEIENSFYLRLQVRDKPGVL
CCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHEEEHHHCCCEEEEEEEECCCCCHH
AQITKVLGDNKVSLASVLQKHRLTTVVPLVLITHPVKEQFINKSLKELKKIEDVVSIDSL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IRVEEESI
HHHHCCCC
>Mature Secondary Structure
MIKIGLLGLGTVGSGVVTIMENNKESIRRKVGTSLAIEKVLVKNLDKERDLDIDSRVLTS
CEEEEEEECCCCCCCEEEEEECCHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHHHHC
NIEDIVYNPDIDLVVELIGGEEPACQYIKEAINRGKSVVTANKLVIAKHGTEILKLAREK
CCHHEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECEEEEEECCHHHHHHHHHC
GVQVSYEGSVGGGIPIIRPLKESLAANRIHEIYGILNGTTNYILTKMTREGRKFQEVLAE
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
AQKLGYAESDPSSDIEGYDAAYKIAILASIAFETSIDISSVYVEGIDGISVDDIELAREL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHH
GYVIKLLAIGKRCERGLDIRVHPTFIPRSHPLALVSDVYNAVYLHGDAVGDVMSYGKGAG
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHEEECCCHHHHHHHCCCCCC
QMPTGSAVVADIIQVARDIHSGRVVTPSLDTTIKHRVVDINEIENSFYLRLQVRDKPGVL
CCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHEEEHHHCCCEEEEEEEECCCCCHH
AQITKVLGDNKVSLASVLQKHRLTTVVPLVLITHPVKEQFINKSLKELKKIEDVVSIDSL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IRVEEESI
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]