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The map label for this gene is uppS [H]

Identifier: 220931614

GI number: 220931614

Start: 826099

End: 826821

Strand: Direct

Name: uppS [H]

Synonym: Hore_07700

Alternate gene names: 220931614

Gene position: 826099-826821 (Clockwise)

Preceding gene: 220931613

Following gene: 220931615

Centisome position: 32.04

GC content: 39.42

Gene sequence:

>723_bases
ATGAATATACCTTCCCATGTAGCAATAATAATGGATGGAAATGGCCGCTGGGCTCAGGAAAAGGGTCTGCCAAGGTATGC
CGGGCACCGCGAGGGAGTTAAAACCCTTAAAAAAATAATTAAAAAGGCAGGGGAAATGAAAATACCCTGTCTAACTGTTT
ATGCTTTTTCTACTGAAAACTGGAGACGCCCCCGTAAAGAAGTTGATTTTTTAATGAAATTATTCAAAGAAACCCTTAAG
AATGAGTCACAGGAGCTTGCCAGTAAAAATGTCCGGGTCAATATAATTGGAAGGCGAAATGGCCTCTCCAAAAGTCTCAT
AAATGCAATTGAGTATATCGAAAAAATTACCCGGGATAAGAACGGGATGGAATTAAATATCGCCTTTAATTATGGAGGAC
GGGCTGAAATTGTTGATAGTGTAAAAAAAGTGGTGCAGGATGTCAATCAGGGTCTGGCCCTTGACGAGCTTGATGAGAAT
AATTTTTCAAAATACCTATATAACCCCAGGTGGCCTGAAGTAGAATTACTGATAAGAACTGGTGGAGAAATGAGAATAAG
TAATTATATGTTATGGCAACTGGCCTATGCTGAACTGTATTTTATTGATAAATGCTGGCCTGATTTTAATGGAGAGGACC
TGGAAAAAGCTATAAAGGTTTTTCAACAGCGAGATCGTAGATTTGGTGGATTACCTGAAGTGGGGGACGATAAAAATGCT
TAG

Upstream 100 bases:

>100_bases
GATTCAGAACAGATCAAGATTATCTGGAGTTATGAAAAATATAGGTAGGACGGTCCCCCTCATTATGAGGGGGTGATTAG
TTTTAGAATAGGGTGATAAA

Downstream 100 bases:

>100_bases
TTATAGAGTCTTAAGTGCTATTGCAGGAATTATATTATTTATATTATTTGTATTCTGGGGTTCTTTTCCTTATTTTCTTT
TTGTATCACTTATTGCTATC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MNIPSHVAIIMDGNGRWAQEKGLPRYAGHREGVKTLKKIIKKAGEMKIPCLTVYAFSTENWRRPRKEVDFLMKLFKETLK
NESQELASKNVRVNIIGRRNGLSKSLINAIEYIEKITRDKNGMELNIAFNYGGRAEIVDSVKKVVQDVNQGLALDELDEN
NFSKYLYNPRWPEVELLIRTGGEMRISNYMLWQLAYAELYFIDKCWPDFNGEDLEKAIKVFQQRDRRFGGLPEVGDDKNA

Sequences:

>Translated_240_residues
MNIPSHVAIIMDGNGRWAQEKGLPRYAGHREGVKTLKKIIKKAGEMKIPCLTVYAFSTENWRRPRKEVDFLMKLFKETLK
NESQELASKNVRVNIIGRRNGLSKSLINAIEYIEKITRDKNGMELNIAFNYGGRAEIVDSVKKVVQDVNQGLALDELDEN
NFSKYLYNPRWPEVELLIRTGGEMRISNYMLWQLAYAELYFIDKCWPDFNGEDLEKAIKVFQQRDRRFGGLPEVGDDKNA
>Mature_240_residues
MNIPSHVAIIMDGNGRWAQEKGLPRYAGHREGVKTLKKIIKKAGEMKIPCLTVYAFSTENWRRPRKEVDFLMKLFKETLK
NESQELASKNVRVNIIGRRNGLSKSLINAIEYIEKITRDKNGMELNIAFNYGGRAEIVDSVKKVVQDVNQGLALDELDEN
NFSKYLYNPRWPEVELLIRTGGEMRISNYMLWQLAYAELYFIDKCWPDFNGEDLEKAIKVFQQRDRRFGGLPEVGDDKNA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=36, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=36, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786371, Length=233, Percent_Identity=47.6394849785408, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.283185840708, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=35.8490566037736, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=34.5622119815668, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=32.15859030837, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27765; Mature: 27765

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPSHVAIIMDGNGRWAQEKGLPRYAGHREGVKTLKKIIKKAGEMKIPCLTVYAFSTEN
CCCCCEEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCH
WRRPRKEVDFLMKLFKETLKNESQELASKNVRVNIIGRRNGLSKSLINAIEYIEKITRDK
HCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC
NGMELNIAFNYGGRAEIVDSVKKVVQDVNQGLALDELDENNFSKYLYNPRWPEVELLIRT
CCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEC
GGEMRISNYMLWQLAYAELYFIDKCWPDFNGEDLEKAIKVFQQRDRRFGGLPEVGDDKNA
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNIPSHVAIIMDGNGRWAQEKGLPRYAGHREGVKTLKKIIKKAGEMKIPCLTVYAFSTEN
CCCCCEEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCH
WRRPRKEVDFLMKLFKETLKNESQELASKNVRVNIIGRRNGLSKSLINAIEYIEKITRDK
HCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC
NGMELNIAFNYGGRAEIVDSVKKVVQDVNQGLALDELDENNFSKYLYNPRWPEVELLIRT
CCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEC
GGEMRISNYMLWQLAYAELYFIDKCWPDFNGEDLEKAIKVFQQRDRRFGGLPEVGDDKNA
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]