Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 220931573

GI number: 220931573

Start: 789345

End: 790679

Strand: Direct

Name: ffh [H]

Synonym: Hore_07290

Alternate gene names: 220931573

Gene position: 789345-790679 (Clockwise)

Preceding gene: 220931572

Following gene: 220931574

Centisome position: 30.62

GC content: 40.97

Gene sequence:

>1335_bases
ATGATTTTTGAAGGTCTGGCCAGCAAACTTCAGGCAACCCTGAAAAAACTGAGGAATAAAGGGAAATTAAGTGGAAAAGA
TGTTAAAAGTGCCCTGAAAGAAGTAAAACTGGCTCTGCTTGAAGCAGATGTTAATTATAAAGTTGTGAAACAATTTATAA
AAAGGGTTCAGGAAAGGGCAGTCGGGCACGAAGTAATGGAAAGTTTAACACCAGGCCAGCAGGTTATTAAAATAGTAAAT
GATGAATTAACAGAATTAATGGGTGGTAATAAAAGTGACCTCTCTATATCGTCCAAGCCACCAACTATTATTATGCTGGT
TGGATTACAGGGGGCCGGTAAGACTACCAGTGCTGCTAAACTGGCCCGCTTTTTAAAGAAAAAGGGTAAAAAACCCCTTC
TGGTTGCGGGAGATATATACAGGCCGGCTGCAATAAAGCAGCTTCAGGTACTAGGTGACAGGCTTGATATTCCTGTCTTC
AGTATGGGGGATAAAAATAGTCCGGTAGATATTTCTAAAGCCGGTATCAGTAAAGCTGAAAGTAATGGTAATGATGTGGT
TATTATTGATACAGCCGGAAGACTCCATATCGATGAAGAGATGATGGACGAACTTAAATCTATAAAAAGTAATGTTCGAC
CCCATGAAATATTACTGGTTGTTGATGCCATGACAGGACAGGATGCAGTTAATGTTGCCGAGAATTTTAGTGAATCTCTT
GGTATTGACGGCATTATTTTGACAAAACTGGATGGGGATGCCCGGGGTGGGGCTGCCCTGTCTATTAAAGCGGTGACCGG
TAAACCTATTAAATTTGTTGGTATGGGTGAAAAACTGGATGCTCTTGAATCCTTTCACCCGGACAGGATGTCCTCCCGGA
TTCTGGGAATGGGGGATGTCCTCAGCTTAATTGAAAAAGCAGAGGCCAGTATTGATGCCAAAAAAGCTGAAGAACTGGAG
AAAAAAATCAGGCAGAATGAATTTAGTCTTGAAGATTTCCTGGAACAGCTCCAGCAGGTAAGGAACATGGGCCCCCTTGA
CCAGATTTTAGGAATGATTCCCGGGGTTAGCGGCCAACTTAAAAATCTGCAGGTTGACGAAAAACAGCTTGATAGAATTG
AAGCCATAATAAATTCAATGACTATAGAGGAAAGAAAAAATCCTGAAATTATTAATGGCAGTCGGAGAAGACGAATAGCC
AGAGGTAGTGGCACAAAAATACAGGATGTAAACAGGTTACTGAAGCAGTTTAAACAGACTAAAAAGATGATGAAACAGCT
TAATGGAATGCAGAAAAGTGGGCGAAAAAAGATGAGATTCCCCTTTATGGGTTAA

Upstream 100 bases:

>100_bases
GGTATATCAGTGATAACAAAAATATAAATAAAACTGTTAAAAAGGATTTACTGTGCAGAATAGATAAAATTTCAAAAGAG
GTCTAAGGGAGGAAAATTTA

Downstream 100 bases:

>100_bases
GTTAATTTTTTGAAAGAAAGGAGGTGAAATAAAAATGGCAGTAAAGATTAGATTAAGAAGGATGGGTAGTAAAAGAAATG
CCCATTATCGACTGGTAGTT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MIFEGLASKLQATLKKLRNKGKLSGKDVKSALKEVKLALLEADVNYKVVKQFIKRVQERAVGHEVMESLTPGQQVIKIVN
DELTELMGGNKSDLSISSKPPTIIMLVGLQGAGKTTSAAKLARFLKKKGKKPLLVAGDIYRPAAIKQLQVLGDRLDIPVF
SMGDKNSPVDISKAGISKAESNGNDVVIIDTAGRLHIDEEMMDELKSIKSNVRPHEILLVVDAMTGQDAVNVAENFSESL
GIDGIILTKLDGDARGGAALSIKAVTGKPIKFVGMGEKLDALESFHPDRMSSRILGMGDVLSLIEKAEASIDAKKAEELE
KKIRQNEFSLEDFLEQLQQVRNMGPLDQILGMIPGVSGQLKNLQVDEKQLDRIEAIINSMTIEERKNPEIINGSRRRRIA
RGSGTKIQDVNRLLKQFKQTKKMMKQLNGMQKSGRKKMRFPFMG

Sequences:

>Translated_444_residues
MIFEGLASKLQATLKKLRNKGKLSGKDVKSALKEVKLALLEADVNYKVVKQFIKRVQERAVGHEVMESLTPGQQVIKIVN
DELTELMGGNKSDLSISSKPPTIIMLVGLQGAGKTTSAAKLARFLKKKGKKPLLVAGDIYRPAAIKQLQVLGDRLDIPVF
SMGDKNSPVDISKAGISKAESNGNDVVIIDTAGRLHIDEEMMDELKSIKSNVRPHEILLVVDAMTGQDAVNVAENFSESL
GIDGIILTKLDGDARGGAALSIKAVTGKPIKFVGMGEKLDALESFHPDRMSSRILGMGDVLSLIEKAEASIDAKKAEELE
KKIRQNEFSLEDFLEQLQQVRNMGPLDQILGMIPGVSGQLKNLQVDEKQLDRIEAIINSMTIEERKNPEIINGSRRRRIA
RGSGTKIQDVNRLLKQFKQTKKMMKQLNGMQKSGRKKMRFPFMG
>Mature_444_residues
MIFEGLASKLQATLKKLRNKGKLSGKDVKSALKEVKLALLEADVNYKVVKQFIKRVQERAVGHEVMESLTPGQQVIKIVN
DELTELMGGNKSDLSISSKPPTIIMLVGLQGAGKTTSAAKLARFLKKKGKKPLLVAGDIYRPAAIKQLQVLGDRLDIPVF
SMGDKNSPVDISKAGISKAESNGNDVVIIDTAGRLHIDEEMMDELKSIKSNVRPHEILLVVDAMTGQDAVNVAENFSESL
GIDGIILTKLDGDARGGAALSIKAVTGKPIKFVGMGEKLDALESFHPDRMSSRILGMGDVLSLIEKAEASIDAKKAEELE
KKIRQNEFSLEDFLEQLQQVRNMGPLDQILGMIPGVSGQLKNLQVDEKQLDRIEAIINSMTIEERKNPEIINGSRRRRIA
RGSGTKIQDVNRLLKQFKQTKKMMKQLNGMQKSGRKKMRFPFMG

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=450, Percent_Identity=34.4444444444444, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI226371618, Length=358, Percent_Identity=35.195530726257, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI23308697, Length=305, Percent_Identity=27.8688524590164, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI295424842, Length=305, Percent_Identity=27.8688524590164, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI89061728, Length=139, Percent_Identity=37.410071942446, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=53.7558685446009, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=36.3636363636364, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=32.4137931034483, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI193206261, Length=260, Percent_Identity=32.3076923076923, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=415, Percent_Identity=35.1807228915663, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320498, Length=300, Percent_Identity=28, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647949, Length=441, Percent_Identity=32.1995464852608, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=30.0653594771242, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48861; Mature: 48861

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFEGLASKLQATLKKLRNKGKLSGKDVKSALKEVKLALLEADVNYKVVKQFIKRVQERA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGHEVMESLTPGQQVIKIVNDELTELMGGNKSDLSISSKPPTIIMLVGLQGAGKTTSAAK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCCCCCHHHHH
LARFLKKKGKKPLLVAGDIYRPAAIKQLQVLGDRLDIPVFSMGDKNSPVDISKAGISKAE
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCCC
SNGNDVVIIDTAGRLHIDEEMMDELKSIKSNVRPHEILLVVDAMTGQDAVNVAENFSESL
CCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHC
GIDGIILTKLDGDARGGAALSIKAVTGKPIKFVGMGEKLDALESFHPDRMSSRILGMGDV
CCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHCCCHHHHHHHCCHHHH
LSLIEKAEASIDAKKAEELEKKIRQNEFSLEDFLEQLQQVRNMGPLDQILGMIPGVSGQL
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
KNLQVDEKQLDRIEAIINSMTIEERKNPEIINGSRRRRIARGSGTKIQDVNRLLKQFKQT
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
KKMMKQLNGMQKSGRKKMRFPFMG
HHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIFEGLASKLQATLKKLRNKGKLSGKDVKSALKEVKLALLEADVNYKVVKQFIKRVQERA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGHEVMESLTPGQQVIKIVNDELTELMGGNKSDLSISSKPPTIIMLVGLQGAGKTTSAAK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCCCCCHHHHH
LARFLKKKGKKPLLVAGDIYRPAAIKQLQVLGDRLDIPVFSMGDKNSPVDISKAGISKAE
HHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCCC
SNGNDVVIIDTAGRLHIDEEMMDELKSIKSNVRPHEILLVVDAMTGQDAVNVAENFSESL
CCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHC
GIDGIILTKLDGDARGGAALSIKAVTGKPIKFVGMGEKLDALESFHPDRMSSRILGMGDV
CCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHCCCHHHHHHHCCHHHH
LSLIEKAEASIDAKKAEELEKKIRQNEFSLEDFLEQLQQVRNMGPLDQILGMIPGVSGQL
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
KNLQVDEKQLDRIEAIINSMTIEERKNPEIINGSRRRRIARGSGTKIQDVNRLLKQFKQT
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
KKMMKQLNGMQKSGRKKMRFPFMG
HHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]