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The map label for this gene is hgdC [H]

Identifier: 220931555

GI number: 220931555

Start: 768225

End: 769220

Strand: Direct

Name: hgdC [H]

Synonym: Hore_07110

Alternate gene names: 220931555

Gene position: 768225-769220 (Clockwise)

Preceding gene: 220931554

Following gene: 220931557

Centisome position: 29.8

GC content: 40.46

Gene sequence:

>996_bases
ATGGGTAAGTATTACCTGGGGGTAGATGTAGGTTCTGTCAGTACTGATATGGCTTTAATAGATCCCTTTGGTAATTTAAT
TGAGAAAATCTATTTAAGAACAAAAGGACAACCAATCGAGGTCATAAAAAGGGGTTTAAAAAAATTAAAAGAGAATTATG
GTAGTATTAAAGTTGCTGGTGTTGGAACTACTGGAAGTGGGAGAAAACTGGCCGGTGTAATGCTGGGAGCTGATGTAATT
AAAAATGAAATAACTGCCCATGCTGTGGCTGCTACCCATCTTGTCCCTGATGCCAGAACTGTTCTGGAAATAGGGGGCCA
GGACTCTAAAATAATAATACTTAAAGATGGTATTGCAGTGGATTTTGCCATGAATACGGTTTGCGCAGCCGGTACCGGTT
CTTTTCTCGATCAACAGGCCGCCAGACTCGGCATTTCGATAGGTGAATTTAGCCGGTTAGCCTTAAAAGCCAGAAGTCCG
GTGCGGATTGCTGGAAGGTGTTCTGTATTTGCGGAATCAGATATGATACATAAACAACAACTTGGTCATGACCTGCCAGA
AATAGTAGCCGGATTGTGTGAAGCCATGGTTAGAAATTATTTGAACAATGTGGCCAAGGGGAAGGACATAAAACCCCCCG
TTGTATTCCAGGGAGGGGTTGCTGCAAACATTGGAATTAAAAAGGCTTTTGAAAAAGAGCTACATACAGAGATATATGTA
CCGGAACATAATGGGGTTATGGGTGCTATTGGTGCTGCGTTACTGGCAATGGAAGAAGTTCGTTCCCGTAAAAAAGAAAC
CTCTTTTAAGGGTTTTGAGGTTACAGAGTTTAAATTTAAGACTACAAGCTTTGAATGTAAGGGTTGTCCCAACAGGTGTG
AAATAGTAAATATTAATCAGGATGGAAAAACTATTGCCAGATGGGGTTCTAAGTGTTTAAAGTGGGATATGACAGAAGAC
AAAAAAAAAGAGGAAGTTAATTTAAACCCCTCTTAA

Upstream 100 bases:

>100_bases
TTTCTTGATGAACATACCGGTGATGCTGGATTTAAAACAAGACTGGAGGCTTTTATTGACCTCATTGAGCGGAAAAAGAA
TAATAAAGGAGTGTTACAAC

Downstream 100 bases:

>100_bases
TCAAAGTATTACGTGGTCAAGTTGTCACAGGTGAAAGAGATATCTGAAGTAGCAATTGATTGGTGTGCGGGTAATGATTT
GCTACTGGCACAATCATTAC

Product: putative CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MGKYYLGVDVGSVSTDMALIDPFGNLIEKIYLRTKGQPIEVIKRGLKKLKENYGSIKVAGVGTTGSGRKLAGVMLGADVI
KNEITAHAVAATHLVPDARTVLEIGGQDSKIIILKDGIAVDFAMNTVCAAGTGSFLDQQAARLGISIGEFSRLALKARSP
VRIAGRCSVFAESDMIHKQQLGHDLPEIVAGLCEAMVRNYLNNVAKGKDIKPPVVFQGGVAANIGIKKAFEKELHTEIYV
PEHNGVMGAIGAALLAMEEVRSRKKETSFKGFEVTEFKFKTTSFECKGCPNRCEIVNINQDGKTIARWGSKCLKWDMTED
KKKEEVNLNPS

Sequences:

>Translated_331_residues
MGKYYLGVDVGSVSTDMALIDPFGNLIEKIYLRTKGQPIEVIKRGLKKLKENYGSIKVAGVGTTGSGRKLAGVMLGADVI
KNEITAHAVAATHLVPDARTVLEIGGQDSKIIILKDGIAVDFAMNTVCAAGTGSFLDQQAARLGISIGEFSRLALKARSP
VRIAGRCSVFAESDMIHKQQLGHDLPEIVAGLCEAMVRNYLNNVAKGKDIKPPVVFQGGVAANIGIKKAFEKELHTEIYV
PEHNGVMGAIGAALLAMEEVRSRKKETSFKGFEVTEFKFKTTSFECKGCPNRCEIVNINQDGKTIARWGSKCLKWDMTED
KKKEEVNLNPS
>Mature_330_residues
GKYYLGVDVGSVSTDMALIDPFGNLIEKIYLRTKGQPIEVIKRGLKKLKENYGSIKVAGVGTTGSGRKLAGVMLGADVIK
NEITAHAVAATHLVPDARTVLEIGGQDSKIIILKDGIAVDFAMNTVCAAGTGSFLDQQAARLGISIGEFSRLALKARSPV
RIAGRCSVFAESDMIHKQQLGHDLPEIVAGLCEAMVRNYLNNVAKGKDIKPPVVFQGGVAANIGIKKAFEKELHTEIYVP
EHNGVMGAIGAALLAMEEVRSRKKETSFKGFEVTEFKFKTTSFECKGCPNRCEIVNINQDGKTIARWGSKCLKWDMTEDK
KKEEVNLNPS

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=262, Percent_Identity=33.587786259542, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 35857; Mature: 35726

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKYYLGVDVGSVSTDMALIDPFGNLIEKIYLRTKGQPIEVIKRGLKKLKENYGSIKVAG
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEE
VGTTGSGRKLAGVMLGADVIKNEITAHAVAATHLVPDARTVLEIGGQDSKIIILKDGIAV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCEE
DFAMNTVCAAGTGSFLDQQAARLGISIGEFSRLALKARSPVRIAGRCSVFAESDMIHKQQ
EHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHH
LGHDLPEIVAGLCEAMVRNYLNNVAKGKDIKPPVVFQGGVAANIGIKKAFEKELHTEIYV
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEECCCHHHHHHHHHCCEEEE
PEHNGVMGAIGAALLAMEEVRSRKKETSFKGFEVTEFKFKTTSFECKGCPNRCEIVNINQ
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEEECCCCCCCEEEEECC
DGKTIARWGSKCLKWDMTEDKKKEEVNLNPS
CCHHHHHHCHHHEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKYYLGVDVGSVSTDMALIDPFGNLIEKIYLRTKGQPIEVIKRGLKKLKENYGSIKVAG
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEE
VGTTGSGRKLAGVMLGADVIKNEITAHAVAATHLVPDARTVLEIGGQDSKIIILKDGIAV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCEE
DFAMNTVCAAGTGSFLDQQAARLGISIGEFSRLALKARSPVRIAGRCSVFAESDMIHKQQ
EHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHH
LGHDLPEIVAGLCEAMVRNYLNNVAKGKDIKPPVVFQGGVAANIGIKKAFEKELHTEIYV
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEECCCHHHHHHHHHCCEEEE
PEHNGVMGAIGAALLAMEEVRSRKKETSFKGFEVTEFKFKTTSFECKGCPNRCEIVNINQ
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEEECCCCCCCEEEEECC
DGKTIARWGSKCLKWDMTEDKKKEEVNLNPS
CCHHHHHHCHHHEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]