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The map label for this gene is ppnK [H]

Identifier: 220931499

GI number: 220931499

Start: 710603

End: 711385

Strand: Direct

Name: ppnK [H]

Synonym: Hore_06550

Alternate gene names: 220931499

Gene position: 710603-711385 (Clockwise)

Preceding gene: 220931498

Following gene: 220931500

Centisome position: 27.56

GC content: 39.59

Gene sequence:

>783_bases
ATGTTGGAAAAAAGGGGATTAAATTATCGTGTTGAAAGCCAGACTGCCAGAGCTCTAGGGTTTGATAGGAATAGCTGTCC
CCTGACCAGAATGAAGGAATTGGTTGATTTAGTTTTTATATTTGGAGGAGATGGTACCCTGCTTCATACAGCCCATCATT
TTATCGGTGCTGATATACCTCTGTTAGGTGTAAACCTGGGAAGGCTTGGCTTTTTAGCTGAGGTTGAGGGCAATGAATTA
AGCAAAGCTCTTGAGTTTATACTAGAAGAAAACTATAAAATAGAAAAAAGAATGTTACTGGAAGCTAAAGTATATAGTGA
TGGGGAGGAGGTATACCGGAGCTATGCCCTTAACGATGTAGTTATAAACAGGGGTGCCAGGTCAAGGATGGTCAGTATCC
AGCTCTATATTAATCACCAGGCTGTGACATCATACCGGGCAGATGGTTTAATTATTGCAACCACTACAGGATCGACTGCT
TATTCTCTTTCGGCCGGGGGGCCTATCGTTAATCCTAAATTAAAAGCGATGGTAGTTACCCCTATTTGTCCCCATACGCT
ATATATAAGGCCTATGGTTGTTTCTGAAGAAGAAAAATTGAAAGTAACTGTTGAAGGACAGGATGCTATGATGTTTACAG
CTGATGGGCAGTATAATTATCCTTTATCAACAGGAGATGAAATCTTAATCTCTGCTTCCAATAAAGAAATTAAGATGGTA
AAGTTGCCAGACAGGAATTTTTATTCAATACTTCATCAGAAGATGAAAGTGGGGTTAGTTTAA

Upstream 100 bases:

>100_bases
CCCATAAGAGGTTAGGGGGTTGATATAAATTTTAACAGTAGGGGTTGTCCTTAATACCGATAAAAAAGAGGGATTTAATA
TAGTTTGTTCGTTTTTAAAC

Downstream 100 bases:

>100_bases
GGGGGGGTTATTATGAAGAGTAAAAGGCATTTGAAGATCTTAAACATCATAAAAAATGAGGATATAAGTACCCAGGAAGA
ACTGGTGGAACGTCTTCATG

Product: ATP-NAD/AcoX kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLEKRGLNYRVESQTARALGFDRNSCPLTRMKELVDLVFIFGGDGTLLHTAHHFIGADIPLLGVNLGRLGFLAEVEGNEL
SKALEFILEENYKIEKRMLLEAKVYSDGEEVYRSYALNDVVINRGARSRMVSIQLYINHQAVTSYRADGLIIATTTGSTA
YSLSAGGPIVNPKLKAMVVTPICPHTLYIRPMVVSEEEKLKVTVEGQDAMMFTADGQYNYPLSTGDEILISASNKEIKMV
KLPDRNFYSILHQKMKVGLV

Sequences:

>Translated_260_residues
MLEKRGLNYRVESQTARALGFDRNSCPLTRMKELVDLVFIFGGDGTLLHTAHHFIGADIPLLGVNLGRLGFLAEVEGNEL
SKALEFILEENYKIEKRMLLEAKVYSDGEEVYRSYALNDVVINRGARSRMVSIQLYINHQAVTSYRADGLIIATTTGSTA
YSLSAGGPIVNPKLKAMVVTPICPHTLYIRPMVVSEEEKLKVTVEGQDAMMFTADGQYNYPLSTGDEILISASNKEIKMV
KLPDRNFYSILHQKMKVGLV
>Mature_260_residues
MLEKRGLNYRVESQTARALGFDRNSCPLTRMKELVDLVFIFGGDGTLLHTAHHFIGADIPLLGVNLGRLGFLAEVEGNEL
SKALEFILEENYKIEKRMLLEAKVYSDGEEVYRSYALNDVVINRGARSRMVSIQLYINHQAVTSYRADGLIIATTTGSTA
YSLSAGGPIVNPKLKAMVVTPICPHTLYIRPMVVSEEEKLKVTVEGQDAMMFTADGQYNYPLSTGDEILISASNKEIKMV
KLPDRNFYSILHQKMKVGLV

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=249, Percent_Identity=28.9156626506024, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788968, Length=257, Percent_Identity=34.6303501945525, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320794, Length=239, Percent_Identity=33.4728033472803, Blast_Score=141, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322509, Length=238, Percent_Identity=36.5546218487395, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325068, Length=205, Percent_Identity=33.1707317073171, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28573830, Length=223, Percent_Identity=33.6322869955157, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28573832, Length=223, Percent_Identity=33.6322869955157, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161077047, Length=223, Percent_Identity=33.6322869955157, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28573828, Length=223, Percent_Identity=33.6322869955157, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28573826, Length=223, Percent_Identity=33.6322869955157, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI20129957, Length=248, Percent_Identity=27.8225806451613, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363323, Length=248, Percent_Identity=27.8225806451613, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363321, Length=248, Percent_Identity=27.8225806451613, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653422, Length=248, Percent_Identity=27.8225806451613, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653424, Length=248, Percent_Identity=27.8225806451613, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 28965; Mature: 28965

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRGLNYRVESQTARALGFDRNSCPLTRMKELVDLVFIFGGDGTLLHTAHHFIGADIP
CCCCCCCCEEECCCHHHHHCCCCCCCCHHHHHHHHEEEEEECCCCEEEEEHHHHHCCCCC
LLGVNLGRLGFLAEVEGNELSKALEFILEENYKIEKRMLLEAKVYSDGEEVYRSYALNDV
EEEECCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHE
VINRGARSRMVSIQLYINHQAVTSYRADGLIIATTTGSTAYSLSAGGPIVNPKLKAMVVT
EECCCCCCEEEEEEEEEECHHHEEECCCCEEEEEECCCCEEEECCCCCCCCCCEEEEEEC
PICPHTLYIRPMVVSEEEKLKVTVEGQDAMMFTADGQYNYPLSTGDEILISASNKEIKMV
CCCCCEEEEEEEEECCCCEEEEEEECCCEEEEEECCCEECCCCCCCEEEEEECCCEEEEE
KLPDRNFYSILHQKMKVGLV
ECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEKRGLNYRVESQTARALGFDRNSCPLTRMKELVDLVFIFGGDGTLLHTAHHFIGADIP
CCCCCCCCEEECCCHHHHHCCCCCCCCHHHHHHHHEEEEEECCCCEEEEEHHHHHCCCCC
LLGVNLGRLGFLAEVEGNELSKALEFILEENYKIEKRMLLEAKVYSDGEEVYRSYALNDV
EEEECCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHE
VINRGARSRMVSIQLYINHQAVTSYRADGLIIATTTGSTAYSLSAGGPIVNPKLKAMVVT
EECCCCCCEEEEEEEEEECHHHEEECCCCEEEEEECCCCEEEECCCCCCCCCCEEEEEEC
PICPHTLYIRPMVVSEEEKLKVTVEGQDAMMFTADGQYNYPLSTGDEILISASNKEIKMV
CCCCCEEEEEEEEECCCCEEEEEEECCCEEEEEECCCEECCCCCCCEEEEEECCCEEEEE
KLPDRNFYSILHQKMKVGLV
ECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA