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The map label for this gene is ispA [C]

Identifier: 220931495

GI number: 220931495

Start: 705380

End: 706270

Strand: Direct

Name: ispA [C]

Synonym: Hore_06510

Alternate gene names: 220931495

Gene position: 705380-706270 (Clockwise)

Preceding gene: 220931494

Following gene: 220931496

Centisome position: 27.36

GC content: 41.53

Gene sequence:

>891_bases
TTGAACCAGGTGAATATAAAAGAAATTTTGACTCAATACACCAGTGAAGTCAACAGTGTTTTGAAGGAAATAATGAATAT
TGAGAAAAATGCCCTGGCTCCCGGGCTGGTTAAGGCTATGAAATATAGCCTGTTTTCTGGGGGAAAAAGGCTACGCCCGA
TTTTAACCCTGATGGTGGCTGAGATGTTAGATGGAGATCGTGATAGTGCTTTGCGGGTCGGGGCTTCAATAGAGCTGGTT
CATACTTATTCCCTTATTCATGATGATTTACCCAGTATGGATGATGATGATTTTCGACGGGGGAAACCATCAAACCATAA
AGTGTTTGGCACGGCAACAGCAATACTGGCCGGGGATGCCCTCTTAACATTTGCTTTTAATATATTATCTAAACTTAATT
TGCCTCCGGATAAAGTGTTGAAAATTATTGAAGTTATCAGTCAAGGGGCTGGTCATAACGGCATGGTTGGGGGACAGGTA
CTTGACCTGGAAGCAGAAGATAAAGAAATTTCCCTTGAAGAGCTAAAGAAAATTCATTCCGGTAAAACGGGAGCTCTTTT
TAAAAGCTCTATTTTAGCGGGAGCTTATTGTGCTAATCCTGACCGGACAGAACTTACTGCATTAGAGAGATATGCCAGAT
ACCTGGGGTTGACATTTCAAATAGTTGATGATATTCTTGACGTTACCGGTAATGAGGAAGTACTGGGAAAACGGGTTGGC
CGTGATGATGAACTTAATAAAGCTACCTATCCCCGTTTACTGGGATTGAAACAGGCTGTTAAAGAAGCTGAATTCAATGC
TGAGAAGGCCCGTGATTCCCTTGGGCCTTTTGGTGAAAGAGCCTTTTTATTAAAGCAGCTAGTTGATTATATACTGGTAA
GACAATCATGA

Upstream 100 bases:

>100_bases
ATCAGGAACTTAATAAGGCCGAAGAGAAAATAGAAAAGGTATTAAAAGAAGGTGGTACCTTTACCAGAAGTGTTAGCTTT
GAGGATGGGGGGAGTAATAA

Downstream 100 bases:

>100_bases
CAGGTAACTTAATGATTTCGAATATCTTTAGTATTTATTTTTATGATTACAAAAGCAACCCCTGTTATAAGCTACAAAAT
ATTGAGGGAAAACAGGAATT

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNQVNIKEILTQYTSEVNSVLKEIMNIEKNALAPGLVKAMKYSLFSGGKRLRPILTLMVAEMLDGDRDSALRVGASIELV
HTYSLIHDDLPSMDDDDFRRGKPSNHKVFGTATAILAGDALLTFAFNILSKLNLPPDKVLKIIEVISQGAGHNGMVGGQV
LDLEAEDKEISLEELKKIHSGKTGALFKSSILAGAYCANPDRTELTALERYARYLGLTFQIVDDILDVTGNEEVLGKRVG
RDDELNKATYPRLLGLKQAVKEAEFNAEKARDSLGPFGERAFLLKQLVDYILVRQS

Sequences:

>Translated_296_residues
MNQVNIKEILTQYTSEVNSVLKEIMNIEKNALAPGLVKAMKYSLFSGGKRLRPILTLMVAEMLDGDRDSALRVGASIELV
HTYSLIHDDLPSMDDDDFRRGKPSNHKVFGTATAILAGDALLTFAFNILSKLNLPPDKVLKIIEVISQGAGHNGMVGGQV
LDLEAEDKEISLEELKKIHSGKTGALFKSSILAGAYCANPDRTELTALERYARYLGLTFQIVDDILDVTGNEEVLGKRVG
RDDELNKATYPRLLGLKQAVKEAEFNAEKARDSLGPFGERAFLLKQLVDYILVRQS
>Mature_296_residues
MNQVNIKEILTQYTSEVNSVLKEIMNIEKNALAPGLVKAMKYSLFSGGKRLRPILTLMVAEMLDGDRDSALRVGASIELV
HTYSLIHDDLPSMDDDDFRRGKPSNHKVFGTATAILAGDALLTFAFNILSKLNLPPDKVLKIIEVISQGAGHNGMVGGQV
LDLEAEDKEISLEELKKIHSGKTGALFKSSILAGAYCANPDRTELTALERYARYLGLTFQIVDDILDVTGNEEVLGKRVG
RDDELNKATYPRLLGLKQAVKEAEFNAEKARDSLGPFGERAFLLKQLVDYILVRQS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=30.6382978723404, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786623, Length=267, Percent_Identity=47.1910112359551, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI1789578, Length=264, Percent_Identity=32.9545454545455, Blast_Score=137, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17505681, Length=249, Percent_Identity=28.1124497991968, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24651612, Length=263, Percent_Identity=30.4182509505703, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32620; Mature: 32620

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVNIKEILTQYTSEVNSVLKEIMNIEKNALAPGLVKAMKYSLFSGGKRLRPILTLMVA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
EMLDGDRDSALRVGASIELVHTYSLIHDDLPSMDDDDFRRGKPSNHKVFGTATAILAGDA
HHHCCCCCHHEEECCEEEHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHH
LLTFAFNILSKLNLPPDKVLKIIEVISQGAGHNGMVGGQVLDLEAEDKEISLEELKKIHS
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHC
GKTGALFKSSILAGAYCANPDRTELTALERYARYLGLTFQIVDDILDVTGNEEVLGKRVG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
RDDELNKATYPRLLGLKQAVKEAEFNAEKARDSLGPFGERAFLLKQLVDYILVRQS
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQVNIKEILTQYTSEVNSVLKEIMNIEKNALAPGLVKAMKYSLFSGGKRLRPILTLMVA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
EMLDGDRDSALRVGASIELVHTYSLIHDDLPSMDDDDFRRGKPSNHKVFGTATAILAGDA
HHHCCCCCHHEEECCEEEHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHH
LLTFAFNILSKLNLPPDKVLKIIEVISQGAGHNGMVGGQVLDLEAEDKEISLEELKKIHS
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHC
GKTGALFKSSILAGAYCANPDRTELTALERYARYLGLTFQIVDDILDVTGNEEVLGKRVG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
RDDELNKATYPRLLGLKQAVKEAEFNAEKARDSLGPFGERAFLLKQLVDYILVRQS
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]