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The map label for this gene is mutS2

Identifier: 220931412

GI number: 220931412

Start: 618765

End: 621140

Strand: Direct

Name: mutS2

Synonym: Hore_05680

Alternate gene names: 220931412

Gene position: 618765-621140 (Clockwise)

Preceding gene: 220931411

Following gene: 220931414

Centisome position: 24.0

GC content: 39.44

Gene sequence:

>2376_bases
GTGGAGGAAAGCTCCCTTGAAATACTGGAATTTGATAAAATAATAGACCGTGTTCAGGAATTTGCAGCAACCATCATTGG
AAAGGAAATTATATCCAGACTACAACCGGTCGATAACCTTAATTATGTGAAAAATAAATTACGGGAAGTCAGCTCTGCCC
GTGAAATTCTTGAAGAGTATGGACGGCCTCCCTTTGGCGGTATCAGAGATTTAAGGGAGATAATTGAAAAAGCTGATAAG
GGAATAGTTTTAAGTGTAAAAGAAGTCATGGATGTCAGGTCAACCCTGGAAGGGGTCAGGGAATTAAAAAAATATTCCCG
GGAAATAGGAACAGGAATAGATGATGAGTTGCAGGATATTTATAGCATTATTACTGAAAAATTTGATAGACTTACCCCTT
TAAAACAATTAGAGAATGAAATTAATAGATGTATAGATGAACATGGGGAGATAAAGGATTCTGCCAGTAGAAAGCTCAGA
AGTATAAGGCGGGAGATGGATAGAATTGAGGGTAAAATAAATGATAAGCTCAATTCTATAATAAATAATACAAGGTATCA
GGAAATGCTTCAGGATAAGCTGGTTACCATCAGAGGAAACAGGTATGTTGTCCCTGTTAAAAGCAGTTACAAGAACACTT
TTTCTGGAATAGTTCATGATCAATCAACAAGTGGACTTACCTATTTTATGGAGCCAATGGCTATAGTAAAGCTTAATAAC
AGACTCGGGGAATTGAAAAGAGCCGAAGAACAGGAAATATACAGGATATTGAAAAAGTTGAGTGAAAATATTAAAGAACA
CACCCGGGATCTGAGTGATAATCTGGAGATGGTTTCCCTTCTTGATGTTGATTTTGCCAGAGCCAGGTTCAGTATTGAAA
TAGAAGGTATAGAACCTGGAATTAATGATAAGGGTTTTATTAATATAAGAGGTGGACGCCATCCTTTACTTAAAGTCAAA
CCCGTTCCAATTGATATAACTGTTGGCAATGAGTTTAAAACCCTGGTTATTACCGGTCCCAATACCGGTGGTAAGACCGT
AGCACTTAAAACTGTTGGGTTATTTGTATTAATGGTCCAGGCAGGCCTTCATATACCTGCAGAAGAGGAAACGGTTATCT
CTATTTTTAATGGAGTTTATGCCGATATTGGAGATGAACAAAGTATAGAACAGAATTTGAGTACATTTTCATCCCATATT
AACCGGATTAAGCGGTTTTTAGGTAAGGCTGATGCCAGAAGCCTGGTTCTTCTGGATGAGATCGGGGTTGGTACAGATCC
TCGCGAAGGGGCTGCCCTCGGGGTGGCCATCCTGGAACATTTAAGGGAAAGGGGAGTAACTACTATAGCCACAACTCATT
ACAGTGAAATAAAGAGTTATGCTTACTCCCAGGATGGTGTTGAAAATGCTTCTGTTGAATTTGATATGGAAACCCTTCAA
CCAACCTACCGGCTCCTTATGGGGATTCCCGGTGGAAGTAATGCCTTTGAGATTGCCCTGAAGCTGGGTTTACCCCATGA
TATAATTAAAGATGGTAAGGAGTTAATGAGCGGGGATGATATTAAGGTTGAAAATATTATTTCTGATTTAAATGAAGAAC
GGAAAAAATATGAACAATTAAAAATAGAAATAGAAGAAAGGCTGGAGGCAGTAAAGAAAAAGGAACAGAAGTATGATTCT
TTATTGACCGATCTTGAGAAGAGAAAAAAGAAGTTAATAACAGAAGCCCGGGAAGAGGCTTTACAGATAATTAAAAAGAC
CAGGAAAGAGAGCAAAGAGATTTTACGCCGGTTAAAGAATAAAGAATTTGCTTCCAGGTCTGATATAGACAGGGTTGAGA
ATGAAATCAATTTGAATCTTAAGGAAACCGAAAAAGAAATTAGTGAAAAAAGACAGAACAAAGATGGCCGGACCCGGGTT
AAAGAAATATCCTGTGGTGACCAGGTCAGGTTGAAAAAAACTGGTCAGAAGGGTGAGGTTATTTCTGTTGACCGGGAGAA
AGGAGAGGCTGTTATCCAGGCCGGTATTATGAAAGTAACTACAGGGCTGGATGAAGTAGCGAAAATTGATATACCTGATG
ATACTAAGGACGAACTCTTTCATTCCTATCAGGTCAAGAAAAAAAGCCGGGTTTCTCCTACCCTTGATCTTAGAGGAGAA
CGTTATGAAACAGCCCAGCATAAACTGGATAAATATCTTGATGATGTTTTCCTGGCCGGATTGAAACAGGTAGAAATAAT
TCACGGTAAGGGTACCGGGGCTTTGAGGAAGGCTGTTCATACTGTATTAGAAAAAAACCCCCACATCACCTCTTACCGCC
TGGGAAGGCAGGAAGAAGGTGGGAGTGGGGTGACAATTGCTGACCTCAAATCCTAA

Upstream 100 bases:

>100_bases
CTCGGGGTTGCTGTAGCCCGGAGAGGCTGGCTTGAAAGAGAAGATGTTATTAATACCATGAATGCAGAAGAGTTACAGGA
ATTATTAAGGAGGGATTAAG

Downstream 100 bases:

>100_bases
TTATTAAATTTAAACATATCCCAGAGGTTATCAAAGAAATTCTGCTGTCCATTACCGTGGAGGTCACACTTACGGGTAGG
TATTCTTTCATAGATTACCT

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MEESSLEILEFDKIIDRVQEFAATIIGKEIISRLQPVDNLNYVKNKLREVSSAREILEEYGRPPFGGIRDLREIIEKADK
GIVLSVKEVMDVRSTLEGVRELKKYSREIGTGIDDELQDIYSIITEKFDRLTPLKQLENEINRCIDEHGEIKDSASRKLR
SIRREMDRIEGKINDKLNSIINNTRYQEMLQDKLVTIRGNRYVVPVKSSYKNTFSGIVHDQSTSGLTYFMEPMAIVKLNN
RLGELKRAEEQEIYRILKKLSENIKEHTRDLSDNLEMVSLLDVDFARARFSIEIEGIEPGINDKGFINIRGGRHPLLKVK
PVPIDITVGNEFKTLVITGPNTGGKTVALKTVGLFVLMVQAGLHIPAEEETVISIFNGVYADIGDEQSIEQNLSTFSSHI
NRIKRFLGKADARSLVLLDEIGVGTDPREGAALGVAILEHLRERGVTTIATTHYSEIKSYAYSQDGVENASVEFDMETLQ
PTYRLLMGIPGGSNAFEIALKLGLPHDIIKDGKELMSGDDIKVENIISDLNEERKKYEQLKIEIEERLEAVKKKEQKYDS
LLTDLEKRKKKLITEAREEALQIIKKTRKESKEILRRLKNKEFASRSDIDRVENEINLNLKETEKEISEKRQNKDGRTRV
KEISCGDQVRLKKTGQKGEVISVDREKGEAVIQAGIMKVTTGLDEVAKIDIPDDTKDELFHSYQVKKKSRVSPTLDLRGE
RYETAQHKLDKYLDDVFLAGLKQVEIIHGKGTGALRKAVHTVLEKNPHITSYRLGRQEEGGSGVTIADLKS

Sequences:

>Translated_791_residues
MEESSLEILEFDKIIDRVQEFAATIIGKEIISRLQPVDNLNYVKNKLREVSSAREILEEYGRPPFGGIRDLREIIEKADK
GIVLSVKEVMDVRSTLEGVRELKKYSREIGTGIDDELQDIYSIITEKFDRLTPLKQLENEINRCIDEHGEIKDSASRKLR
SIRREMDRIEGKINDKLNSIINNTRYQEMLQDKLVTIRGNRYVVPVKSSYKNTFSGIVHDQSTSGLTYFMEPMAIVKLNN
RLGELKRAEEQEIYRILKKLSENIKEHTRDLSDNLEMVSLLDVDFARARFSIEIEGIEPGINDKGFINIRGGRHPLLKVK
PVPIDITVGNEFKTLVITGPNTGGKTVALKTVGLFVLMVQAGLHIPAEEETVISIFNGVYADIGDEQSIEQNLSTFSSHI
NRIKRFLGKADARSLVLLDEIGVGTDPREGAALGVAILEHLRERGVTTIATTHYSEIKSYAYSQDGVENASVEFDMETLQ
PTYRLLMGIPGGSNAFEIALKLGLPHDIIKDGKELMSGDDIKVENIISDLNEERKKYEQLKIEIEERLEAVKKKEQKYDS
LLTDLEKRKKKLITEAREEALQIIKKTRKESKEILRRLKNKEFASRSDIDRVENEINLNLKETEKEISEKRQNKDGRTRV
KEISCGDQVRLKKTGQKGEVISVDREKGEAVIQAGIMKVTTGLDEVAKIDIPDDTKDELFHSYQVKKKSRVSPTLDLRGE
RYETAQHKLDKYLDDVFLAGLKQVEIIHGKGTGALRKAVHTVLEKNPHITSYRLGRQEEGGSGVTIADLKS
>Mature_791_residues
MEESSLEILEFDKIIDRVQEFAATIIGKEIISRLQPVDNLNYVKNKLREVSSAREILEEYGRPPFGGIRDLREIIEKADK
GIVLSVKEVMDVRSTLEGVRELKKYSREIGTGIDDELQDIYSIITEKFDRLTPLKQLENEINRCIDEHGEIKDSASRKLR
SIRREMDRIEGKINDKLNSIINNTRYQEMLQDKLVTIRGNRYVVPVKSSYKNTFSGIVHDQSTSGLTYFMEPMAIVKLNN
RLGELKRAEEQEIYRILKKLSENIKEHTRDLSDNLEMVSLLDVDFARARFSIEIEGIEPGINDKGFINIRGGRHPLLKVK
PVPIDITVGNEFKTLVITGPNTGGKTVALKTVGLFVLMVQAGLHIPAEEETVISIFNGVYADIGDEQSIEQNLSTFSSHI
NRIKRFLGKADARSLVLLDEIGVGTDPREGAALGVAILEHLRERGVTTIATTHYSEIKSYAYSQDGVENASVEFDMETLQ
PTYRLLMGIPGGSNAFEIALKLGLPHDIIKDGKELMSGDDIKVENIISDLNEERKKYEQLKIEIEERLEAVKKKEQKYDS
LLTDLEKRKKKLITEAREEALQIIKKTRKESKEILRRLKNKEFASRSDIDRVENEINLNLKETEKEISEKRQNKDGRTRV
KEISCGDQVRLKKTGQKGEVISVDREKGEAVIQAGIMKVTTGLDEVAKIDIPDDTKDELFHSYQVKKKSRVSPTLDLRGE
RYETAQHKLDKYLDDVFLAGLKQVEIIHGKGTGALRKAVHTVLEKNPHITSYRLGRQEEGGSGVTIADLKS

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=524, Percent_Identity=25.763358778626, Blast_Score=126, Evalue=1e-28,
Organism=Homo sapiens, GI36949366, Length=387, Percent_Identity=27.906976744186, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI26638666, Length=273, Percent_Identity=32.2344322344322, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4505253, Length=273, Percent_Identity=32.2344322344322, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4504191, Length=305, Percent_Identity=28.5245901639344, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI26638664, Length=274, Percent_Identity=32.1167883211679, Blast_Score=110, Evalue=8e-24,
Organism=Homo sapiens, GI262231786, Length=231, Percent_Identity=31.6017316017316, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4557761, Length=265, Percent_Identity=27.5471698113208, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1789089, Length=276, Percent_Identity=27.536231884058, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508445, Length=282, Percent_Identity=25.886524822695, Blast_Score=102, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=250, Percent_Identity=28, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539736, Length=302, Percent_Identity=24.8344370860927, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=267, Percent_Identity=24.3445692883895, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=268, Percent_Identity=32.4626865671642, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324482, Length=233, Percent_Identity=29.6137339055794, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=296, Percent_Identity=26.0135135135135, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321109, Length=236, Percent_Identity=30.9322033898305, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321912, Length=292, Percent_Identity=24.3150684931507, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=277, Percent_Identity=27.7978339350181, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664545, Length=278, Percent_Identity=28.0575539568345, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24584320, Length=274, Percent_Identity=26.6423357664234, Blast_Score=100, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_HALOH (B8D298)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508320.1
- ProteinModelPortal:   B8D298
- SMR:   B8D298
- GeneID:   7313540
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_05680
- HOGENOM:   HBG486560
- OMA:   PGLVHDQ
- ProtClustDB:   CLSK2806233
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 89693; Mature: 89693

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESSLEILEFDKIIDRVQEFAATIIGKEIISRLQPVDNLNYVKNKLREVSSAREILEEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GRPPFGGIRDLREIIEKADKGIVLSVKEVMDVRSTLEGVRELKKYSREIGTGIDDELQDI
CCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YSIITEKFDRLTPLKQLENEINRCIDEHGEIKDSASRKLRSIRREMDRIEGKINDKLNSI
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INNTRYQEMLQDKLVTIRGNRYVVPVKSSYKNTFSGIVHDQSTSGLTYFMEPMAIVKLNN
HHHHHHHHHHHHCCEEEECCEEEEECCHHHHHHHHHHEECCCCCCCHHHHCCHHHHHHHH
RLGELKRAEEQEIYRILKKLSENIKEHTRDLSDNLEMVSLLDVDFARARFSIEIEGIEPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCEEEEEEECCCCC
INDKGFINIRGGRHPLLKVKPVPIDITVGNEFKTLVITGPNTGGKTVALKTVGLFVLMVQ
CCCCCEEEECCCCCCCEEEECCEEEEEECCCEEEEEEECCCCCCCEEHHHHHHHHHHHHH
AGLHIPAEEETVISIFNGVYADIGDEQSIEQNLSTFSSHINRIKRFLGKADARSLVLLDE
HCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
IGVGTDPREGAALGVAILEHLRERGVTTIATTHYSEIKSYAYSQDGVENASVEFDMETLQ
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCCCCEEEEHHHHH
PTYRLLMGIPGGSNAFEIALKLGLPHDIIKDGKELMSGDDIKVENIISDLNEERKKYEQL
HHHHHHHCCCCCCCCEEEEEECCCCHHHHHCHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KIEIEERLEAVKKKEQKYDSLLTDLEKRKKKLITEAREEALQIIKKTRKESKEILRRLKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KEFASRSDIDRVENEINLNLKETEKEISEKRQNKDGRTRVKEISCGDQVRLKKTGQKGEV
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCCCE
ISVDREKGEAVIQAGIMKVTTGLDEVAKIDIPDDTKDELFHSYQVKKKSRVSPTLDLRGE
EEEEHHHCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
RYETAQHKLDKYLDDVFLAGLKQVEIIHGKGTGALRKAVHTVLEKNPHITSYRLGRQEEG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCC
GSGVTIADLKS
CCCCEEECCCC
>Mature Secondary Structure
MEESSLEILEFDKIIDRVQEFAATIIGKEIISRLQPVDNLNYVKNKLREVSSAREILEEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GRPPFGGIRDLREIIEKADKGIVLSVKEVMDVRSTLEGVRELKKYSREIGTGIDDELQDI
CCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YSIITEKFDRLTPLKQLENEINRCIDEHGEIKDSASRKLRSIRREMDRIEGKINDKLNSI
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INNTRYQEMLQDKLVTIRGNRYVVPVKSSYKNTFSGIVHDQSTSGLTYFMEPMAIVKLNN
HHHHHHHHHHHHCCEEEECCEEEEECCHHHHHHHHHHEECCCCCCCHHHHCCHHHHHHHH
RLGELKRAEEQEIYRILKKLSENIKEHTRDLSDNLEMVSLLDVDFARARFSIEIEGIEPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCEEEEEEECCCCC
INDKGFINIRGGRHPLLKVKPVPIDITVGNEFKTLVITGPNTGGKTVALKTVGLFVLMVQ
CCCCCEEEECCCCCCCEEEECCEEEEEECCCEEEEEEECCCCCCCEEHHHHHHHHHHHHH
AGLHIPAEEETVISIFNGVYADIGDEQSIEQNLSTFSSHINRIKRFLGKADARSLVLLDE
HCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
IGVGTDPREGAALGVAILEHLRERGVTTIATTHYSEIKSYAYSQDGVENASVEFDMETLQ
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCCCCEEEEHHHHH
PTYRLLMGIPGGSNAFEIALKLGLPHDIIKDGKELMSGDDIKVENIISDLNEERKKYEQL
HHHHHHHCCCCCCCCEEEEEECCCCHHHHHCHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KIEIEERLEAVKKKEQKYDSLLTDLEKRKKKLITEAREEALQIIKKTRKESKEILRRLKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KEFASRSDIDRVENEINLNLKETEKEISEKRQNKDGRTRVKEISCGDQVRLKKTGQKGEV
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCCCE
ISVDREKGEAVIQAGIMKVTTGLDEVAKIDIPDDTKDELFHSYQVKKKSRVSPTLDLRGE
EEEEHHHCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
RYETAQHKLDKYLDDVFLAGLKQVEIIHGKGTGALRKAVHTVLEKNPHITSYRLGRQEEG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCC
GSGVTIADLKS
CCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA