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The map label for this gene is tdh [H]

Identifier: 220931172

GI number: 220931172

Start: 333934

End: 335010

Strand: Direct

Name: tdh [H]

Synonym: Hore_03240

Alternate gene names: 220931172

Gene position: 333934-335010 (Clockwise)

Preceding gene: 220931170

Following gene: 220931173

Centisome position: 12.95

GC content: 37.79

Gene sequence:

>1077_bases
ATGGTAAACTTACCCGAAAAAATGAAGGCACTGGTAGCTTATGCTCCTGGTGATTATCGATTTGAGGAAGTAGATGTGCC
TAGGGCTGGAGAAGGAGAAATTGTTGTTAAAGTAGAAGCCTGTGGAATATGTGCAGGCGATATTAAAGCATATCACGGAG
CTCCAAGCTTTTGGGGTGGTGAAGGTAATCCACCATATATAAAAGCCCCAATGATACCAGGTCATGAATTTATAGGAGAA
ATTGTTGAAAAAGGGGCTGAAGTTTCAGATGATTTTGAAATAGGAGACAGGGTAATTTCTGAACAAATAGTTCCTTGCTG
GGAATGTAAATTTTGTAGAACAGGGCGTTACTGGATGTGTCAAAAGCATGATGTCTATGGATTTCAAAATAATGTAAATG
GTGGTATGGCTGAATATATGAAATTCCCAAAAGAGGCAATAAATTATAAGGTTCCTAAGGATATACCAATTGAAAAGGCT
ATACTCATAGAACCATATGCCTGTTCAAAACATGCCGTTGATAGGGCTAACATTAGTAACGAAGATGTAGTTGTACTATC
AGGGGCAGGAACACTGGGATTGGGTATGGTAGGAGCTATTAAGCTAAGGAATCCTAAATCATTGGTAGTTCTCGATTTAA
AAGATGATAGACTTGAGCTTGCTAAAAAATTTGGAGCAGACATAACAATGAATCCCAAAAAAGAAAATGTTGTAGAAAAA
ATATTGGAAATGACTGATGGGTATGGTTGTGACATTTATATAGAAGCTACCGGTCATCCCAGTAGTGTTCAACAAGGGCT
AGAGGCTATTCGGAAACTTGGTACCTTCGTTGAGTTTAGTGTTTTTGGTGATCTCGTAACCACTGATTGGAGTATTATAA
GTGATCGGAAAGAACTTGATGTTTTAGGTTCCCATTTAGGACCATATTGTTATGAACCGGTTATTGAATGGATAGCTAAT
GGTAAATTACCCACAGAAGGAGTAGTCACCCATAAATTTCCCCTTGAAAAATGGAAAGAAGCTTTTGAAAAAGCAGAAAA
GGGTCAAGATTCAATAAAAGTAGTGCTTGTACCATAA

Upstream 100 bases:

>100_bases
AAAAAATTGTATTGGTAATTCATATTTTTATTTAATATTTTCAAAAAGTAAAGTCTTGCAAAAAAATTATCATTAGTCAA
AAAACAAGGGGGAAAAAATA

Downstream 100 bases:

>100_bases
ATGAATAGACTAACCTCATAGTATAGCAAAAAAATAATATTATCTTAAATAATGGAGAGAGACTAATATAGGATTGGAGG
TAAAAAGGTTATGCAAAAGT

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVNLPEKMKALVAYAPGDYRFEEVDVPRAGEGEIVVKVEACGICAGDIKAYHGAPSFWGGEGNPPYIKAPMIPGHEFIGE
IVEKGAEVSDDFEIGDRVISEQIVPCWECKFCRTGRYWMCQKHDVYGFQNNVNGGMAEYMKFPKEAINYKVPKDIPIEKA
ILIEPYACSKHAVDRANISNEDVVVLSGAGTLGLGMVGAIKLRNPKSLVVLDLKDDRLELAKKFGADITMNPKKENVVEK
ILEMTDGYGCDIYIEATGHPSSVQQGLEAIRKLGTFVEFSVFGDLVTTDWSIISDRKELDVLGSHLGPYCYEPVIEWIAN
GKLPTEGVVTHKFPLEKWKEAFEKAEKGQDSIKVVLVP

Sequences:

>Translated_358_residues
MVNLPEKMKALVAYAPGDYRFEEVDVPRAGEGEIVVKVEACGICAGDIKAYHGAPSFWGGEGNPPYIKAPMIPGHEFIGE
IVEKGAEVSDDFEIGDRVISEQIVPCWECKFCRTGRYWMCQKHDVYGFQNNVNGGMAEYMKFPKEAINYKVPKDIPIEKA
ILIEPYACSKHAVDRANISNEDVVVLSGAGTLGLGMVGAIKLRNPKSLVVLDLKDDRLELAKKFGADITMNPKKENVVEK
ILEMTDGYGCDIYIEATGHPSSVQQGLEAIRKLGTFVEFSVFGDLVTTDWSIISDRKELDVLGSHLGPYCYEPVIEWIAN
GKLPTEGVVTHKFPLEKWKEAFEKAEKGQDSIKVVLVP
>Mature_358_residues
MVNLPEKMKALVAYAPGDYRFEEVDVPRAGEGEIVVKVEACGICAGDIKAYHGAPSFWGGEGNPPYIKAPMIPGHEFIGE
IVEKGAEVSDDFEIGDRVISEQIVPCWECKFCRTGRYWMCQKHDVYGFQNNVNGGMAEYMKFPKEAINYKVPKDIPIEKA
ILIEPYACSKHAVDRANISNEDVVVLSGAGTLGLGMVGAIKLRNPKSLVVLDLKDDRLELAKKFGADITMNPKKENVVEK
ILEMTDGYGCDIYIEATGHPSSVQQGLEAIRKLGTFVEFSVFGDLVTTDWSIISDRKELDVLGSHLGPYCYEPVIEWIAN
GKLPTEGVVTHKFPLEKWKEAFEKAEKGQDSIKVVLVP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=349, Percent_Identity=30.945558739255, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=25.4098360655738, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565154, Length=384, Percent_Identity=25.78125, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=24.5231607629428, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=344, Percent_Identity=28.7790697674419, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790045, Length=342, Percent_Identity=30.1169590643275, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI226510992, Length=340, Percent_Identity=30.8823529411765, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=27.9202279202279, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788407, Length=365, Percent_Identity=27.9452054794521, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786825, Length=407, Percent_Identity=27.027027027027, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788075, Length=369, Percent_Identity=26.5582655826558, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1790718, Length=328, Percent_Identity=28.9634146341463, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082125, Length=363, Percent_Identity=27.5482093663912, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786552, Length=380, Percent_Identity=24.2105263157895, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=349, Percent_Identity=32.6647564469914, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=349, Percent_Identity=29.512893982808, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71997431, Length=382, Percent_Identity=24.0837696335079, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=380, Percent_Identity=24.2105263157895, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=367, Percent_Identity=25.3405994550409, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=320, Percent_Identity=24.375, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=371, Percent_Identity=25.6064690026954, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=283, Percent_Identity=26.1484098939929, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=346, Percent_Identity=28.6127167630058, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322619, Length=344, Percent_Identity=27.3255813953488, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=344, Percent_Identity=27.0348837209302, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=381, Percent_Identity=26.509186351706, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=389, Percent_Identity=26.4781491002571, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=390, Percent_Identity=26.1538461538462, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319621, Length=359, Percent_Identity=25.6267409470752, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=363, Percent_Identity=23.9669421487603, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=315, Percent_Identity=24.4444444444444, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=370, Percent_Identity=23.5135135135135, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=180, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=174, Percent_Identity=28.1609195402299, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17137530, Length=345, Percent_Identity=28.1159420289855, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737897, Length=345, Percent_Identity=28.1159420289855, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI17737895, Length=381, Percent_Identity=26.7716535433071, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 39621; Mature: 39621

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNLPEKMKALVAYAPGDYRFEEVDVPRAGEGEIVVKVEACGICAGDIKAYHGAPSFWGG
CCCCHHHHHHEEEECCCCCEEEEECCCCCCCCCEEEEEEECCEECCCHHHHCCCCCCCCC
EGNPPYIKAPMIPGHEFIGEIVEKGAEVSDDFEIGDRVISEQIVPCWECKFCRTGRYWMC
CCCCCEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEE
QKHDVYGFQNNVNGGMAEYMKFPKEAINYKVPKDIPIEKAILIEPYACSKHAVDRANISN
ECCCCCCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHCCCCC
EDVVVLSGAGTLGLGMVGAIKLRNPKSLVVLDLKDDRLELAKKFGADITMNPKKENVVEK
CCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCCEEECCCHHHHHHH
ILEMTDGYGCDIYIEATGHPSSVQQGLEAIRKLGTFVEFSVFGDLVTTDWSIISDRKELD
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCHHHHCCCHHHH
VLGSHLGPYCYEPVIEWIANGKLPTEGVVTHKFPLEKWKEAFEKAEKGQDSIKVVLVP
HHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MVNLPEKMKALVAYAPGDYRFEEVDVPRAGEGEIVVKVEACGICAGDIKAYHGAPSFWGG
CCCCHHHHHHEEEECCCCCEEEEECCCCCCCCCEEEEEEECCEECCCHHHHCCCCCCCCC
EGNPPYIKAPMIPGHEFIGEIVEKGAEVSDDFEIGDRVISEQIVPCWECKFCRTGRYWMC
CCCCCEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEE
QKHDVYGFQNNVNGGMAEYMKFPKEAINYKVPKDIPIEKAILIEPYACSKHAVDRANISN
ECCCCCCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHCCCCC
EDVVVLSGAGTLGLGMVGAIKLRNPKSLVVLDLKDDRLELAKKFGADITMNPKKENVVEK
CCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHCCCEEECCCHHHHHHH
ILEMTDGYGCDIYIEATGHPSSVQQGLEAIRKLGTFVEFSVFGDLVTTDWSIISDRKELD
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCHHHHCCCHHHH
VLGSHLGPYCYEPVIEWIANGKLPTEGVVTHKFPLEKWKEAFEKAEKGQDSIKVVLVP
HHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]