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The map label for this gene is nqo1 [H]

Identifier: 220931145

GI number: 220931145

Start: 306160

End: 307386

Strand: Direct

Name: nqo1 [H]

Synonym: Hore_02970

Alternate gene names: 220931145

Gene position: 306160-307386 (Clockwise)

Preceding gene: 220931144

Following gene: 220931146

Centisome position: 11.88

GC content: 39.45

Gene sequence:

>1227_bases
ATGACTGAAAGACTTTTTTTAAAGCAAAATGAAGTCAGTGATTTTGATAGTTATAAGTTTCCGGCCCTGAAAAGGGCCCT
GGACATGGATAAAAAGGATATTATTGAGGAACTTAAGAAATCAGGTCTCAGAGGAAGAGGAGGGGCTGGCTTTCCAACCG
GGTTGAAGTGGGAATTAGCCTTAAAGGAAAAAGCTGGAGAGAAATATATAATCTGTAATGGTGATGAAGGAGAACCTGGT
ACTTTTAAAGATCGATATTTACTAGAAAATAGTCCCTTGAAGGTACTGGAGGGAATATTAATCGGTGCCTATACCATTGG
TGCTCATCAGGGGTATATTTATATCCGGGGGGAATATGCTTTACCCATTAATATATTTAGACAGGTAATTAAGGAAGCAA
AGAAAAGAGGTATTCTGGGTAATAGGGTAATGGGTAGTGATTATAGTTTTGATCTCAAGCTAATTAAAGGAGCCGGGGCC
TATGTATGTGGTGATGAAACTTCATTAATTAATTCCATAGAAGGAAAACGTGGTACCTCCAGGATTAAGCCACCTTATCC
AACCCGGCAGGGTTTATTTAATAAACCAACAGTTGTTAATAATGTTGAAACTCTGGCAGCAGCTGCTGAAATAATTCTAC
AGGGGGCTGATAAATATGGTTCAATGGGAACAGAACAGAGTAGAGGGACCAAACTGGTCTGTTTGAGTGGTGATATATGT
AATCCGGGTGTCTATGAAGTGGAATTTGGTACTATGACCATAAAAGAATTAATCGATACCTTTGGTGGTGGTGTTAAATG
TAGTAGTGGGCTTAAATTTGTAATCCCCGGGGGAATCTCAACATCAGTCCTGAAAGATGATGAACTGGATATTCCCTACA
CTTATGAGGACATTGAAAAAAAGGGGAGTTCTCTGGGATCTGGAGCTGTGGTGGTAGTGAGTGAAGACCATTACCTGCCG
GATTTAATGTTAAATGTATCCCGGTTTTTTATGGATGAGACCTGTGGGACCTGTTTTCCCTGTAGAGAAGGTAATAGGAG
GGTTCATCTGCTATTAAAAAATAAAATCAGTGATGGCCGATTTGACCGGGATGAAAAGAAATTAATATCTGATATTGGTA
GGGCTATTCATCTGGCTGCTAGATGTGGCCTCGGACAGACTTCATTAAATTTTGTAACTTCAGTTTTAAATAAATTTGAA
GATGAATTAATGGTCGGGAGGGATTAG

Upstream 100 bases:

>100_bases
CCGGTTATGATGGTTAATGACAGAATTTATACCAGGGTTAGTCCTAATATGGCTCTTGAAATACTGAGAGATTGCGTATA
GTAAGGGGAGGGAAATAAAT

Downstream 100 bases:

>100_bases
AGTGGTAAAAATAAATATTGATGGGCTTGATCTGGAGGTCAGAGACGGAATTAGTATCCTGGAAGCTGCTCGCCAGGCCC
ATATTAAAATACCAACCCTA

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I chain 1; NDH-1 subunit 1 [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTERLFLKQNEVSDFDSYKFPALKRALDMDKKDIIEELKKSGLRGRGGAGFPTGLKWELALKEKAGEKYIICNGDEGEPG
TFKDRYLLENSPLKVLEGILIGAYTIGAHQGYIYIRGEYALPINIFRQVIKEAKKRGILGNRVMGSDYSFDLKLIKGAGA
YVCGDETSLINSIEGKRGTSRIKPPYPTRQGLFNKPTVVNNVETLAAAAEIILQGADKYGSMGTEQSRGTKLVCLSGDIC
NPGVYEVEFGTMTIKELIDTFGGGVKCSSGLKFVIPGGISTSVLKDDELDIPYTYEDIEKKGSSLGSGAVVVVSEDHYLP
DLMLNVSRFFMDETCGTCFPCREGNRRVHLLLKNKISDGRFDRDEKKLISDIGRAIHLAARCGLGQTSLNFVTSVLNKFE
DELMVGRD

Sequences:

>Translated_408_residues
MTERLFLKQNEVSDFDSYKFPALKRALDMDKKDIIEELKKSGLRGRGGAGFPTGLKWELALKEKAGEKYIICNGDEGEPG
TFKDRYLLENSPLKVLEGILIGAYTIGAHQGYIYIRGEYALPINIFRQVIKEAKKRGILGNRVMGSDYSFDLKLIKGAGA
YVCGDETSLINSIEGKRGTSRIKPPYPTRQGLFNKPTVVNNVETLAAAAEIILQGADKYGSMGTEQSRGTKLVCLSGDIC
NPGVYEVEFGTMTIKELIDTFGGGVKCSSGLKFVIPGGISTSVLKDDELDIPYTYEDIEKKGSSLGSGAVVVVSEDHYLP
DLMLNVSRFFMDETCGTCFPCREGNRRVHLLLKNKISDGRFDRDEKKLISDIGRAIHLAARCGLGQTSLNFVTSVLNKFE
DELMVGRD
>Mature_407_residues
TERLFLKQNEVSDFDSYKFPALKRALDMDKKDIIEELKKSGLRGRGGAGFPTGLKWELALKEKAGEKYIICNGDEGEPGT
FKDRYLLENSPLKVLEGILIGAYTIGAHQGYIYIRGEYALPINIFRQVIKEAKKRGILGNRVMGSDYSFDLKLIKGAGAY
VCGDETSLINSIEGKRGTSRIKPPYPTRQGLFNKPTVVNNVETLAAAAEIILQGADKYGSMGTEQSRGTKLVCLSGDICN
PGVYEVEFGTMTIKELIDTFGGGVKCSSGLKFVIPGGISTSVLKDDELDIPYTYEDIEKKGSSLGSGAVVVVSEDHYLPD
LMLNVSRFFMDETCGTCFPCREGNRRVHLLLKNKISDGRFDRDEKKLISDIGRAIHLAARCGLGQTSLNFVTSVLNKFED
ELMVGRD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=373, Percent_Identity=39.6782841823056, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI260656005, Length=373, Percent_Identity=39.6782841823056, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1788620, Length=324, Percent_Identity=42.9012345679012, Blast_Score=286, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17531727, Length=373, Percent_Identity=41.2868632707775, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI45550452, Length=357, Percent_Identity=41.1764705882353, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI19920794, Length=373, Percent_Identity=38.3378016085791, Blast_Score=258, Evalue=8e-69,
Organism=Drosophila melanogaster, GI24653819, Length=322, Percent_Identity=38.1987577639752, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24653817, Length=293, Percent_Identity=36.1774744027304, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44925; Mature: 44794

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERLFLKQNEVSDFDSYKFPALKRALDMDKKDIIEELKKSGLRGRGGAGFPTGLKWELA
CCCCEEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
LKEKAGEKYIICNGDEGEPGTFKDRYLLENSPLKVLEGILIGAYTIGAHQGYIYIRGEYA
ECCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHEEEEEECCCCEEEEEECEE
LPINIFRQVIKEAKKRGILGNRVMGSDYSFDLKLIKGAGAYVCGDETSLINSIEGKRGTS
CCHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCCEEECCCHHHHHHCCCCCCCC
RIKPPYPTRQGLFNKPTVVNNVETLAAAAEIILQGADKYGSMGTEQSRGTKLVCLSGDIC
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEECCCC
NPGVYEVEFGTMTIKELIDTFGGGVKCSSGLKFVIPGGISTSVLKDDELDIPYTYEDIEK
CCCEEEEEECHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCEECCCCCCCCCCHHHHHH
KGSSLGSGAVVVVSEDHYLPDLMLNVSRFFMDETCGTCFPCREGNRRVHLLLKNKISDGR
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCC
FDRDEKKLISDIGRAIHLAARCGLGQTSLNFVTSVLNKFEDELMVGRD
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TERLFLKQNEVSDFDSYKFPALKRALDMDKKDIIEELKKSGLRGRGGAGFPTGLKWELA
CCCEEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
LKEKAGEKYIICNGDEGEPGTFKDRYLLENSPLKVLEGILIGAYTIGAHQGYIYIRGEYA
ECCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHEEEEEECCCCEEEEEECEE
LPINIFRQVIKEAKKRGILGNRVMGSDYSFDLKLIKGAGAYVCGDETSLINSIEGKRGTS
CCHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCCEEECCCHHHHHHCCCCCCCC
RIKPPYPTRQGLFNKPTVVNNVETLAAAAEIILQGADKYGSMGTEQSRGTKLVCLSGDIC
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEEEEECCCC
NPGVYEVEFGTMTIKELIDTFGGGVKCSSGLKFVIPGGISTSVLKDDELDIPYTYEDIEK
CCCEEEEEECHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCEECCCCCCCCCCHHHHHH
KGSSLGSGAVVVVSEDHYLPDLMLNVSRFFMDETCGTCFPCREGNRRVHLLLKNKISDGR
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCC
FDRDEKKLISDIGRAIHLAARCGLGQTSLNFVTSVLNKFEDELMVGRD
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9020134 [H]