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The map label for this gene is hisI [H]

Identifier: 220931073

GI number: 220931073

Start: 231793

End: 232437

Strand: Direct

Name: hisI [H]

Synonym: Hore_02250

Alternate gene names: 220931073

Gene position: 231793-232437 (Clockwise)

Preceding gene: 220931072

Following gene: 220931076

Centisome position: 8.99

GC content: 39.38

Gene sequence:

>645_bases
ATGAAAGTAGATTTAGAAAACCTCAACTTTGATGACAGGGGTCTAATTCCGGCTGTTTTACAGGATGTAGAAAGCCGGAA
GGTTTTAATGGTAGCCTATATGAACAGAGAAGCCCTGGTTAGAACCCTGGAGACAGGAAAGGCCTGGTTTTACAGTCGTT
CCCGGCAAAAATTATGGTTAAAAGGGGAGACATCAGGTAATTATCAGCTGGTTAAGGAAATAAGGATTGACTGTGATTCC
GATACCCTTCTGGTCCTGGTTAAACCCGAAGGACCTGCCTGTCACACCGGTCATGAATCATGTTTTTACCGGAATATACT
AACAGAAAAGGGAAGAGATCAGGGCCGGAAACATCTGATTGACCTAGATTTTATTAAACGGCTTTTTGAGTTAATTAAGG
ATAGAAAAATAAATCCTACTCCGGGGTCTTATACTTCATATCTTTTCAGGGAAGGTATTGATAAAGTATGTAAGAAGATA
GGGGAAGAGGCCGCTGAAGTAATTATTGGTGCTAAAAATAAATCAAAACAGGAAGTTATTTACGAAAGTGCTGATCTTAT
TTATCATCTTCTGGTTTTAATGGTTATAATGGATACCACCCCGGGAGAGGTAATAAATGAGTTGAAAAAAAGGCATAAGG
AGTAG

Upstream 100 bases:

>100_bases
CTCAATTTTTCATGAAAAAACATATTCAGTTAGTGAAGTAAAAGAGTACCTGGCAGGTCATGGAATCCCGGTCAGGATAG
AATAGGAATGGGGGTATTTA

Downstream 100 bases:

>100_bases
TCCTGTCCGGGCAGTCAGGTGTAAGGTTTTTAATAACCTTAAGGGGACTGCCCGGTTTTTTTAATTAATATCTTGATTGA
AAATTTATTTATCTCTGGAC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKVDLENLNFDDRGLIPAVLQDVESRKVLMVAYMNREALVRTLETGKAWFYSRSRQKLWLKGETSGNYQLVKEIRIDCDS
DTLLVLVKPEGPACHTGHESCFYRNILTEKGRDQGRKHLIDLDFIKRLFELIKDRKINPTPGSYTSYLFREGIDKVCKKI
GEEAAEVIIGAKNKSKQEVIYESADLIYHLLVLMVIMDTTPGEVINELKKRHKE

Sequences:

>Translated_214_residues
MKVDLENLNFDDRGLIPAVLQDVESRKVLMVAYMNREALVRTLETGKAWFYSRSRQKLWLKGETSGNYQLVKEIRIDCDS
DTLLVLVKPEGPACHTGHESCFYRNILTEKGRDQGRKHLIDLDFIKRLFELIKDRKINPTPGSYTSYLFREGIDKVCKKI
GEEAAEVIIGAKNKSKQEVIYESADLIYHLLVLMVIMDTTPGEVINELKKRHKE
>Mature_214_residues
MKVDLENLNFDDRGLIPAVLQDVESRKVLMVAYMNREALVRTLETGKAWFYSRSRQKLWLKGETSGNYQLVKEIRIDCDS
DTLLVLVKPEGPACHTGHESCFYRNILTEKGRDQGRKHLIDLDFIKRLFELIKDRKINPTPGSYTSYLFREGIDKVCKKI
GEEAAEVIIGAKNKSKQEVIYESADLIYHLLVLMVIMDTTPGEVINELKKRHKE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=200, Percent_Identity=43, Blast_Score=163, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6319819, Length=187, Percent_Identity=33.1550802139037, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24689; Mature: 24689

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVDLENLNFDDRGLIPAVLQDVESRKVLMVAYMNREALVRTLETGKAWFYSRSRQKLWL
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCHHHHEECCCCEEEE
KGETSGNYQLVKEIRIDCDSDTLLVLVKPEGPACHTGHESCFYRNILTEKGRDQGRKHLI
ECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHEE
DLDFIKRLFELIKDRKINPTPGSYTSYLFREGIDKVCKKIGEEAAEVIIGAKNKSKQEVI
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YESADLIYHLLVLMVIMDTTPGEVINELKKRHKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKVDLENLNFDDRGLIPAVLQDVESRKVLMVAYMNREALVRTLETGKAWFYSRSRQKLWL
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCHHHHEECCCCEEEE
KGETSGNYQLVKEIRIDCDSDTLLVLVKPEGPACHTGHESCFYRNILTEKGRDQGRKHLI
ECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHEE
DLDFIKRLFELIKDRKINPTPGSYTSYLFREGIDKVCKKIGEEAAEVIIGAKNKSKQEVI
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YESADLIYHLLVLMVIMDTTPGEVINELKKRHKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]