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The map label for this gene is nuoG [C]

Identifier: 220931030

GI number: 220931030

Start: 187499

End: 189499

Strand: Direct

Name: nuoG [C]

Synonym: Hore_01810

Alternate gene names: 220931030

Gene position: 187499-189499 (Clockwise)

Preceding gene: 220931029

Following gene: 220931033

Centisome position: 7.27

GC content: 43.63

Gene sequence:

>2001_bases
ATGTCTGATACTTTAGTAATAAACGGAAAAACTGTTGCGATAAATGGTGAGAAGAATCTGCTTGAGCTGATAAGAAAACA
GGGGATTGAGCTACCAACCTTTTGTTACCATTCTGAATTAAGTGTTTATGGAGCCTGTAGGATGTGTCTTGTTGAAGAGG
AGAATATGGGGATTATTGCAACCTGTTCAACGGCACCCCAACCGGGGATGAATATAAAAACCCATTCTCCCAGGGTACAA
CGGATAAGAAAGATGGCTCTGGAATTACTACTGGCTAACCATGATCGGGATTGTACTACCTGTTCCCGGAATGGGAATTG
TAAGCTTCAGGACCTGGCCCAGAGGTTTGGCATAGATGAGGTAAGGTTTGGTACCAGGGAAGAAGTACTACCGGTTGATA
ACAGTAGTCCTTCAATTGTACGCAATCCCAATAAGTGTATACTGTGTGGGGACTGTGTCCGGACCTGTCAGGAAATTCAG
GGCATCGGGGTACTGGATTTTGCCAACCGTGGTTCCAAATCTATAGTGGCTCCAGCTTTTAATAAAGACCTGATTGAGGT
TGACTGTGTGGCCTGTGGTCAGTGTGTTGCCGTATGTCCGACCGGAGCTTTGACAATAAAATCAGATATTAGTCGGGTCT
GGGAAGCAATTAATGATCCCGCGAAAACCGTAGTTGTCCAGATTGCGCCTGCTGTCAGGGTAGCTATCGGTGAAGAATTT
GGCATGGAACCTGGAGAAATCCAGATGGGACAGCTGGTTGCTGCCCTCAAAAGGCTTGGGTTTGATAAAGTCTTTGATAC
CAGCTTTGCAGCTGACCTGACAGTTATGGAAGAAACGGCTGAATTTATTGAGAGATTTAAAGAAGGTAAGAAATTGCCAC
AGTTTACTTCCTGCTGTCCGGCCTGGGTTAAATATGCTGAAGAGTATGCCCAGGACTTCCTGGATAACCTGTCCAGCTGT
AAGTCACCACAGCAAATGTTCGGTTCTGTAGCCAAGAGGTTCTATAGTCAGGATCTCGGTATTGATCCGGAAGATATGGT
TGTTGTTTCCATAATGCCCTGTACAGCCAAAAAATTTGAAGCTCAGCGTCCTGAATTTATAACAGATGGGGTACCTGATG
TTGACGTAGTTATAACCACCCAGGAAGTAGCAAGCATGATTAAAAAGTCTGGCCTGGTTTTCTCTGAACTGGGGATAGAA
TCCCTCGATATGCCTTTAGGATTTTCTACCGGGGCCGGTGTTATTTTCGGTGTTACCGGTGGGGTTTCAGAGGCTGTTCT
TAGAAATGCCTATGAAAAGATAACCGGAGATAACCTTGATGATGTAGAATTTAAGGAAGTAAGGGGCTTTGATGGAATAA
AAGAAGCAGAAGTAGAACTGGATGGTAAAACTGTAAGACTGGCGGTTGTCCACGGTCTGAGTAATGTCGGTGATCTTATT
AAGGCGATTAAAAAAGGTGAAAAAGAATATGACCTGATTGAAGTTATGGCCTGTCCTGGCGGTTGTATTGGCGGTGGAGG
ACAGCCTACTCCTAATAACACAGAGGTCAGAGAAAAGAGGGCGCAGGGTATGTACAACTGTGATAAGTTATCAGCCCTTC
ACAAATCCCAGGAAAACCCCATGGTCAACGACTTTTACCGCCGCTGGTTTGGTGAAGAGAATAGTGATGTAACCCATAAA
CACTTACACACCTCCTATGAAGAAAAGCAGAGGATCAATACTAAAGGAATTGAATTAAACACAAGTGAAAGTAGTGAGGA
GGTTGTACCGGTTCAGGTCTGTGTAGGAACCTGCTGTTATCTTCATGGTTCCTACGACCTCTTACAGGGTCTTATAGAAA
GGGTTGAAGAAGAGGGGTTAAGTGATAAGGTAGATATAGAAGCAACTTTCTGTTTTGAAAACTGTAAAAACGCGCCTTCT
GTTAAAGTAGGCAATCAGCTTTTAAGTAAGGTTGAAAGTGTTGATGATATTTTAAAACACTTAAAGCCTGCTTTAAAATA
A

Upstream 100 bases:

>100_bases
TGGTAAGGTTAAAGAGCCCTTTGTAATTGATCAGGATAAATGTATTAAGTGTGGTGCCTGTTATGAGGCCTGTAAATTTA
ACGCTGTGGAGGTGGGATAA

Downstream 100 bases:

>100_bases
AGAAATATCCCTTTTGATATACTCCCCAGGGGTAGGTTATTAGATAAAAAATGGTACTAGAATGGGAGTATATTGAATAA
ACCAGTTAAATTGAATAAAC

Product: NADH dehydrogenase I subunit G

Products: NA

Alternate protein names: CpI; Fe-only hydrogenase; [Fe] hydrogenase [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSDTLVINGKTVAINGEKNLLELIRKQGIELPTFCYHSELSVYGACRMCLVEEENMGIIATCSTAPQPGMNIKTHSPRVQ
RIRKMALELLLANHDRDCTTCSRNGNCKLQDLAQRFGIDEVRFGTREEVLPVDNSSPSIVRNPNKCILCGDCVRTCQEIQ
GIGVLDFANRGSKSIVAPAFNKDLIEVDCVACGQCVAVCPTGALTIKSDISRVWEAINDPAKTVVVQIAPAVRVAIGEEF
GMEPGEIQMGQLVAALKRLGFDKVFDTSFAADLTVMEETAEFIERFKEGKKLPQFTSCCPAWVKYAEEYAQDFLDNLSSC
KSPQQMFGSVAKRFYSQDLGIDPEDMVVVSIMPCTAKKFEAQRPEFITDGVPDVDVVITTQEVASMIKKSGLVFSELGIE
SLDMPLGFSTGAGVIFGVTGGVSEAVLRNAYEKITGDNLDDVEFKEVRGFDGIKEAEVELDGKTVRLAVVHGLSNVGDLI
KAIKKGEKEYDLIEVMACPGGCIGGGGQPTPNNTEVREKRAQGMYNCDKLSALHKSQENPMVNDFYRRWFGEENSDVTHK
HLHTSYEEKQRINTKGIELNTSESSEEVVPVQVCVGTCCYLHGSYDLLQGLIERVEEEGLSDKVDIEATFCFENCKNAPS
VKVGNQLLSKVESVDDILKHLKPALK

Sequences:

>Translated_666_residues
MSDTLVINGKTVAINGEKNLLELIRKQGIELPTFCYHSELSVYGACRMCLVEEENMGIIATCSTAPQPGMNIKTHSPRVQ
RIRKMALELLLANHDRDCTTCSRNGNCKLQDLAQRFGIDEVRFGTREEVLPVDNSSPSIVRNPNKCILCGDCVRTCQEIQ
GIGVLDFANRGSKSIVAPAFNKDLIEVDCVACGQCVAVCPTGALTIKSDISRVWEAINDPAKTVVVQIAPAVRVAIGEEF
GMEPGEIQMGQLVAALKRLGFDKVFDTSFAADLTVMEETAEFIERFKEGKKLPQFTSCCPAWVKYAEEYAQDFLDNLSSC
KSPQQMFGSVAKRFYSQDLGIDPEDMVVVSIMPCTAKKFEAQRPEFITDGVPDVDVVITTQEVASMIKKSGLVFSELGIE
SLDMPLGFSTGAGVIFGVTGGVSEAVLRNAYEKITGDNLDDVEFKEVRGFDGIKEAEVELDGKTVRLAVVHGLSNVGDLI
KAIKKGEKEYDLIEVMACPGGCIGGGGQPTPNNTEVREKRAQGMYNCDKLSALHKSQENPMVNDFYRRWFGEENSDVTHK
HLHTSYEEKQRINTKGIELNTSESSEEVVPVQVCVGTCCYLHGSYDLLQGLIERVEEEGLSDKVDIEATFCFENCKNAPS
VKVGNQLLSKVESVDDILKHLKPALK
>Mature_665_residues
SDTLVINGKTVAINGEKNLLELIRKQGIELPTFCYHSELSVYGACRMCLVEEENMGIIATCSTAPQPGMNIKTHSPRVQR
IRKMALELLLANHDRDCTTCSRNGNCKLQDLAQRFGIDEVRFGTREEVLPVDNSSPSIVRNPNKCILCGDCVRTCQEIQG
IGVLDFANRGSKSIVAPAFNKDLIEVDCVACGQCVAVCPTGALTIKSDISRVWEAINDPAKTVVVQIAPAVRVAIGEEFG
MEPGEIQMGQLVAALKRLGFDKVFDTSFAADLTVMEETAEFIERFKEGKKLPQFTSCCPAWVKYAEEYAQDFLDNLSSCK
SPQQMFGSVAKRFYSQDLGIDPEDMVVVSIMPCTAKKFEAQRPEFITDGVPDVDVVITTQEVASMIKKSGLVFSELGIES
LDMPLGFSTGAGVIFGVTGGVSEAVLRNAYEKITGDNLDDVEFKEVRGFDGIKEAEVELDGKTVRLAVVHGLSNVGDLIK
AIKKGEKEYDLIEVMACPGGCIGGGGQPTPNNTEVREKRAQGMYNCDKLSALHKSQENPMVNDFYRRWFGEENSDVTHKH
LHTSYEEKQRINTKGIELNTSESSEEVVPVQVCVGTCCYLHGSYDLLQGLIERVEEEGLSDKVDIEATFCFENCKNAPSV
KVGNQLLSKVESVDDILKHLKPALK

Specific function: Ndh-1 Shuttles Electrons From NADH, Via Fmn And Iron- Sulfur (Fe-S) Centers, To Quinones In The Respiratory Chain. The Immediate Electron Acceptor For The Enzyme In This Species Is Believed To Be Ubiquinone. Couples The Redox Reaction To Proton Translocat

COG id: COG4624

COG function: function code R; Iron only hydrogenase large subunit, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI11968051, Length=409, Percent_Identity=30.8068459657702, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI6912524, Length=402, Percent_Identity=26.865671641791, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI134284357, Length=361, Percent_Identity=27.9778393351801, Blast_Score=166, Evalue=1e-40,
Organism=Homo sapiens, GI84452151, Length=361, Percent_Identity=27.9778393351801, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI14165461, Length=448, Percent_Identity=25.6696428571429, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI33519475, Length=214, Percent_Identity=35.0467289719626, Blast_Score=133, Evalue=6e-31,
Organism=Escherichia coli, GI145693161, Length=247, Percent_Identity=28.7449392712551, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71995015, Length=346, Percent_Identity=30.0578034682081, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17565758, Length=221, Percent_Identity=33.4841628959276, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32566231, Length=221, Percent_Identity=33.4841628959276, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193209088, Length=222, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324089, Length=376, Percent_Identity=25.531914893617, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI116007470, Length=405, Percent_Identity=28.8888888888889, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI116007466, Length=405, Percent_Identity=28.8888888888889, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI116007468, Length=405, Percent_Identity=28.8888888888889, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI116007464, Length=405, Percent_Identity=28.8888888888889, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI116007462, Length=282, Percent_Identity=30.4964539007092, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24640559, Length=203, Percent_Identity=35.9605911330049, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640557, Length=203, Percent_Identity=35.9605911330049, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR009016
- InterPro:   IPR004108
- InterPro:   IPR003149
- InterPro:   IPR013352
- InterPro:   IPR001041 [H]

Pfam domain/function: PF02906 Fe_hyd_lg_C; PF02256 Fe_hyd_SSU [H]

EC number: =1.12.7.2 [H]

Molecular weight: Translated: 73143; Mature: 73012

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLVINGKTVAINGEKNLLELIRKQGIELPTFCYHSELSVYGACRMCLVEEENMGIIA
CCCEEEECCEEEEECCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHEEEEEECCCCCEEE
TCSTAPQPGMNIKTHSPRVQRIRKMALELLLANHDRDCTTCSRNGNCKLQDLAQRFGIDE
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCH
VRFGTREEVLPVDNSSPSIVRNPNKCILCGDCVRTCQEIQGIGVLDFANRGSKSIVAPAF
HCCCCCCCEECCCCCCCCEEECCCCEEEEHHHHHHHHHHCCCCEEEECCCCCCCEECCCC
NKDLIEVDCVACGQCVAVCPTGALTIKSDISRVWEAINDPAKTVVVQIAPAVRVAIGEEF
CCCCEEEHHHHHCCEEEECCCCCEEHHHHHHHHHHHHCCCHHEEEEEECCHHHEEHHHHH
GMEPGEIQMGQLVAALKRLGFDKVFDTSFAADLTVMEETAEFIERFKEGKKLPQFTSCCP
CCCCCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AWVKYAEEYAQDFLDNLSSCKSPQQMFGSVAKRFYSQDLGIDPEDMVVVSIMPCTAKKFE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHH
AQRPEFITDGVPDVDVVITTQEVASMIKKSGLVFSELGIESLDMPLGFSTGAGVIFGVTG
CCCCCHHCCCCCCCEEEEEHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCEEEEECC
GVSEAVLRNAYEKITGDNLDDVEFKEVRGFDGIKEAEVELDGKTVRLAVVHGLSNVGDLI
CHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEECCCEEEEEEECCHHHHHHHH
KAIKKGEKEYDLIEVMACPGGCIGGGGQPTPNNTEVREKRAQGMYNCDKLSALHKSQENP
HHHHCCCCHHCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
MVNDFYRRWFGEENSDVTHKHLHTSYEEKQRINTKGIELNTSESSEEVVPVQVCVGTCCY
CHHHHHHHHCCCCCCCCCHHHHHCCHHHHHCCCCCCEEEECCCCCCCEEHHHHHHHHHHH
LHGSYDLLQGLIERVEEEGLSDKVDIEATFCFENCKNAPSVKVGNQLLSKVESVDDILKH
HCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LKPALK
HHHHCC
>Mature Secondary Structure 
SDTLVINGKTVAINGEKNLLELIRKQGIELPTFCYHSELSVYGACRMCLVEEENMGIIA
CCEEEECCEEEEECCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHEEEEEECCCCCEEE
TCSTAPQPGMNIKTHSPRVQRIRKMALELLLANHDRDCTTCSRNGNCKLQDLAQRFGIDE
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCH
VRFGTREEVLPVDNSSPSIVRNPNKCILCGDCVRTCQEIQGIGVLDFANRGSKSIVAPAF
HCCCCCCCEECCCCCCCCEEECCCCEEEEHHHHHHHHHHCCCCEEEECCCCCCCEECCCC
NKDLIEVDCVACGQCVAVCPTGALTIKSDISRVWEAINDPAKTVVVQIAPAVRVAIGEEF
CCCCEEEHHHHHCCEEEECCCCCEEHHHHHHHHHHHHCCCHHEEEEEECCHHHEEHHHHH
GMEPGEIQMGQLVAALKRLGFDKVFDTSFAADLTVMEETAEFIERFKEGKKLPQFTSCCP
CCCCCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AWVKYAEEYAQDFLDNLSSCKSPQQMFGSVAKRFYSQDLGIDPEDMVVVSIMPCTAKKFE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHH
AQRPEFITDGVPDVDVVITTQEVASMIKKSGLVFSELGIESLDMPLGFSTGAGVIFGVTG
CCCCCHHCCCCCCCEEEEEHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCEEEEECC
GVSEAVLRNAYEKITGDNLDDVEFKEVRGFDGIKEAEVELDGKTVRLAVVHGLSNVGDLI
CHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEECCCEEEEEEECCHHHHHHHH
KAIKKGEKEYDLIEVMACPGGCIGGGGQPTPNNTEVREKRAQGMYNCDKLSALHKSQENP
HHHHCCCCHHCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
MVNDFYRRWFGEENSDVTHKHLHTSYEEKQRINTKGIELNTSESSEEVVPVQVCVGTCCY
CHHHHHHHHCCCCCCCCCHHHHHCCHHHHHCCCCCCEEEECCCCCCCEEHHHHHHHHHHH
LHGSYDLLQGLIERVEEEGLSDKVDIEATFCFENCKNAPSVKVGNQLLSKVESVDDILKH
HCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LKPALK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1911757; 9836629; 10529166 [H]