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The map label for this gene is ndoA [H]

Identifier: 220931023

GI number: 220931023

Start: 178847

End: 179197

Strand: Direct

Name: ndoA [H]

Synonym: Hore_01740

Alternate gene names: 220931023

Gene position: 178847-179197 (Clockwise)

Preceding gene: 220931022

Following gene: 220931024

Centisome position: 6.94

GC content: 39.6

Gene sequence:

>351_bases
GTGAATGTTACCAGAGGAGATGTTTTTTATGCTGACTTAAACCCGGTAGTGGGGTCAGAGCAGGGTGGTGTGAGGCCGGT
TCTTATCATTCAGAATGATATCGGTAATAAGTATAGCCCGACAGTAATTGTTGCTGCTATTACTTCAAAAATAAATAAGG
CTAAATTACCCACTCATGTGGAAATCGCTGCAAGTGAAAGTAACCTTGAGAAAGATTCGGTTATTCTTTTAGAGCAGATA
AGAACCATAGATAAAAAACGGCTCCAGCGCCATGTAACCCACCTGGATAATGGTATAATCGAAAAGGTTGATGAGGCTAT
TGAAATTAGCCTGGGATTAATAGAACTTTAA

Upstream 100 bases:

>100_bases
GAGATGAGTGATATTAACCGGGAACTGGCTGATGAGGGGATTACTTACGATGCCCTTACCATCAATTTTTATGAAAAAAG
TCTAGCGGAGTGTGAATAAT

Downstream 100 bases:

>100_bases
GGGTCCTTTGGAATTAGACCAGGGGATCTTTTTTTATTTGTTTTATCTTAAGGAGGATTTGGAGGAACTGATTTAGAAGT
ATATAAGCACAGGTTTAACT

Product: transcriptional modulator of MazE/toxin, MazF

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MNVTRGDVFYADLNPVVGSEQGGVRPVLIIQNDIGNKYSPTVIVAAITSKINKAKLPTHVEIAASESNLEKDSVILLEQI
RTIDKKRLQRHVTHLDNGIIEKVDEAIEISLGLIEL

Sequences:

>Translated_116_residues
MNVTRGDVFYADLNPVVGSEQGGVRPVLIIQNDIGNKYSPTVIVAAITSKINKAKLPTHVEIAASESNLEKDSVILLEQI
RTIDKKRLQRHVTHLDNGIIEKVDEAIEISLGLIEL
>Mature_116_residues
MNVTRGDVFYADLNPVVGSEQGGVRPVLIIQNDIGNKYSPTVIVAAITSKINKAKLPTHVEIAASESNLEKDSVILLEQI
RTIDKKRLQRHVTHLDNGIIEKVDEAIEISLGLIEL

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 12753; Mature: 12753

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTRGDVFYADLNPVVGSEQGGVRPVLIIQNDIGNKYSPTVIVAAITSKINKAKLPTHV
CCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEHHHHCCCCCCCEE
EIAASESNLEKDSVILLEQIRTIDKKRLQRHVTHLDNGIIEKVDEAIEISLGLIEL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEC
>Mature Secondary Structure
MNVTRGDVFYADLNPVVGSEQGGVRPVLIIQNDIGNKYSPTVIVAAITSKINKAKLPTHV
CCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEHHHHCCCCCCCEE
EIAASESNLEKDSVILLEQIRTIDKKRLQRHVTHLDNGIIEKVDEAIEISLGLIEL
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]