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The map label for this gene is glmS [H]

Identifier: 220931006

GI number: 220931006

Start: 161831

End: 163657

Strand: Direct

Name: glmS [H]

Synonym: Hore_01570

Alternate gene names: 220931006

Gene position: 161831-163657 (Clockwise)

Preceding gene: 220931005

Following gene: 220931007

Centisome position: 6.28

GC content: 41.22

Gene sequence:

>1827_bases
ATGTGCGGAATTGTTGGATATATAGGGGAAGAAGAAGCCCCATCGATATTACTTGAAGGATTAAAACGACTTGAATATAG
AGGTTATGATTCGGCAGGTATAGCTGTAAGTGATGGTTATAATATTAATGTTGTTAAAAAAGCAGGTAAGTTGAAGGAAC
TGGAGAACATCGTTTTTTCCAGCCCTCCGGCCGGAACAGCTGGAATTGGCCATACCCGGTGGGCAACCCATGGAGTTCCT
TCTGAGAAAAATTCACATCCTCATTATGATTGCCACGAGAATATTGTAGTGGTTCATAATGGTATAATTGAGAACTTCCA
GGAGTTAAAAGAAGGGTTAGAGGCTGCGGGGCATAGCTTTGTGTCTGATACCGATACTGAGGTTATAGCACATTTAATAG
AAGACTATTATAATGGCGATTTGAAAGATGCCGTTTTTAAAGCTGTGCAGAAGCTGGATGGTTCATATGCCCTGGCTGTT
ATGACAAAAGAGGAGCCGAATAAAATAATTGCTGTAAGAAAAGATAGCCCTTTAATTATCGGGAAAGGCCAGGGGGAAAA
CTATATTGCCTCTGATATACCCGCTTTCCTTAATAACACCAGAAGCTTTTATATCCTTGATGATGGAGAGATAGCTGAAG
TTAGTAAGGATAAAGTAGTAATCTATGATAAAAATGGAGTCAGTATTGATAAAGAGATATTTAAGGTTGACTGGGACCCG
GAAATGGCTGAAAAAAATGGGTATGAGCACTATATGTTAAAAGAAATACACGAACAACCAGATGCTTTAAGACGGGTTCT
TGCCAACAGGGTATCTACTCAAGGTGTTAACCTTGATGAAATTGGATTAACAGCAGAAGAATTAAAAAAATACAGCCAGA
TACAGGTTGTAGCCTGTGGAACGGCCTATTATTCGGGAATGGTCGGTAAATATATCATTGAGGAACTGGCGCGGATACCG
GTTAAAGTTGATGTTGCCTCAGAATTCAGGTATTCTAATCCCATTATTGATAAGGATACTCTGGTAATTGTTGTTAGTCA
GTCAGGGGAAACAGCCGATACCCTGGCTGGATTGAGACTAGCCCGGGAAAAAGGGGCCGAGGTACTGGCCCTGACAAATG
TAGTCGGCAGTACTATAGCCCGTGAGGCTGACCGGGTTCTTTATCTCAAGGCCGGGCCTGAAATTGCTGTAGCTTCGACC
AAAGCCTATTTAACCATGGTCTCTGTTTTTTATCTGCTGGCCGTTCAATTTGCTAAAATTAAAGGAACAATTAATGACGA
TGAATATATGGGACTTGTATCTGACTTAATTAGACTTCCGGAGCTGGCTTCTGAGACTATTAAGGTCTCTGAAGAGAAGG
CGAAAGAAAAGGCCAGATATTTTATTGATTATGATAATTCCTTCTATATTGGCCGTAACTTTGATTATACCATTGCCCTG
GAGGGTGCTTTAAAGTTAAAAGAAATATCATACCTTCATGCTGAAGCTTATCCAGCCGGGGAGTTAAAACACGGTCCTTT
AGCTTTAATAGAAGAGGGGATTCCGGTAGTTGCCGTTGTGACCAGGAGATCACTGTATGATAAAATGTTGAGTAATATAA
AAGAAGTTAAAGCCAGGGGTGCCAATATAACAGCTGTTGCTATTGCAGGAGATGCGGAGGTTGAAAAAGCTGTTGATGAT
GTTATTTTTATTCCTGAGTGTAATGAATTTTTCAGTGGCCTGCTGGCAGTTATTCCGCTTCAGCTTCTGGCATATTATAC
AGCCGTAGGCCGGGGTTTTGATGTTGATCAGCCCCGCAATCTGGCCAAAAGTGTGACTGTGGAATAA

Upstream 100 bases:

>100_bases
CCGGGCCTGAAGTCATTCCTCAAACCCGTGGAGTGATCTACGGAACAAAGGGAATGACAGGCAGAAAAAAACTAAATAAT
AAACCTGGAGGTAACAAAAC

Downstream 100 bases:

>100_bases
GTTCTCAGTGAATTTAATAATATTTATGGAGGGGCATAATCTGCCTCTCCATACTATAATATATTTTAAAAAGTAAAAAA
ATTATTATTACTGGAAGGAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGYIGEEEAPSILLEGLKRLEYRGYDSAGIAVSDGYNINVVKKAGKLKELENIVFSSPPAGTAGIGHTRWATHGVP
SEKNSHPHYDCHENIVVVHNGIIENFQELKEGLEAAGHSFVSDTDTEVIAHLIEDYYNGDLKDAVFKAVQKLDGSYALAV
MTKEEPNKIIAVRKDSPLIIGKGQGENYIASDIPAFLNNTRSFYILDDGEIAEVSKDKVVIYDKNGVSIDKEIFKVDWDP
EMAEKNGYEHYMLKEIHEQPDALRRVLANRVSTQGVNLDEIGLTAEELKKYSQIQVVACGTAYYSGMVGKYIIEELARIP
VKVDVASEFRYSNPIIDKDTLVIVVSQSGETADTLAGLRLAREKGAEVLALTNVVGSTIAREADRVLYLKAGPEIAVAST
KAYLTMVSVFYLLAVQFAKIKGTINDDEYMGLVSDLIRLPELASETIKVSEEKAKEKARYFIDYDNSFYIGRNFDYTIAL
EGALKLKEISYLHAEAYPAGELKHGPLALIEEGIPVVAVVTRRSLYDKMLSNIKEVKARGANITAVAIAGDAEVEKAVDD
VIFIPECNEFFSGLLAVIPLQLLAYYTAVGRGFDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGYIGEEEAPSILLEGLKRLEYRGYDSAGIAVSDGYNINVVKKAGKLKELENIVFSSPPAGTAGIGHTRWATHGVP
SEKNSHPHYDCHENIVVVHNGIIENFQELKEGLEAAGHSFVSDTDTEVIAHLIEDYYNGDLKDAVFKAVQKLDGSYALAV
MTKEEPNKIIAVRKDSPLIIGKGQGENYIASDIPAFLNNTRSFYILDDGEIAEVSKDKVVIYDKNGVSIDKEIFKVDWDP
EMAEKNGYEHYMLKEIHEQPDALRRVLANRVSTQGVNLDEIGLTAEELKKYSQIQVVACGTAYYSGMVGKYIIEELARIP
VKVDVASEFRYSNPIIDKDTLVIVVSQSGETADTLAGLRLAREKGAEVLALTNVVGSTIAREADRVLYLKAGPEIAVAST
KAYLTMVSVFYLLAVQFAKIKGTINDDEYMGLVSDLIRLPELASETIKVSEEKAKEKARYFIDYDNSFYIGRNFDYTIAL
EGALKLKEISYLHAEAYPAGELKHGPLALIEEGIPVVAVVTRRSLYDKMLSNIKEVKARGANITAVAIAGDAEVEKAVDD
VIFIPECNEFFSGLLAVIPLQLLAYYTAVGRGFDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIVGYIGEEEAPSILLEGLKRLEYRGYDSAGIAVSDGYNINVVKKAGKLKELENIVFSSPPAGTAGIGHTRWATHGVP
SEKNSHPHYDCHENIVVVHNGIIENFQELKEGLEAAGHSFVSDTDTEVIAHLIEDYYNGDLKDAVFKAVQKLDGSYALAV
MTKEEPNKIIAVRKDSPLIIGKGQGENYIASDIPAFLNNTRSFYILDDGEIAEVSKDKVVIYDKNGVSIDKEIFKVDWDP
EMAEKNGYEHYMLKEIHEQPDALRRVLANRVSTQGVNLDEIGLTAEELKKYSQIQVVACGTAYYSGMVGKYIIEELARIP
VKVDVASEFRYSNPIIDKDTLVIVVSQSGETADTLAGLRLAREKGAEVLALTNVVGSTIAREADRVLYLKAGPEIAVAST
KAYLTMVSVFYLLAVQFAKIKGTINDDEYMGLVSDLIRLPELASETIKVSEEKAKEKARYFIDYDNSFYIGRNFDYTIAL
EGALKLKEISYLHAEAYPAGELKHGPLALIEEGIPVVAVVTRRSLYDKMLSNIKEVKARGANITAVAIAGDAEVEKAVDD
VIFIPECNEFFSGLLAVIPLQLLAYYTAVGRGFDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=35.4319180087848, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=35.9124087591241, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI29570798, Length=260, Percent_Identity=28.4615384615385, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=47.8896103896104, Blast_Score=553, Evalue=1e-158,
Organism=Escherichia coli, GI87082251, Length=314, Percent_Identity=22.6114649681529, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788651, Length=201, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532899, Length=436, Percent_Identity=36.4678899082569, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17532897, Length=436, Percent_Identity=36.4678899082569, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17539970, Length=435, Percent_Identity=34.9425287356322, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17554892, Length=252, Percent_Identity=29.7619047619048, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322745, Length=432, Percent_Identity=35.1851851851852, Blast_Score=266, Evalue=8e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=434, Percent_Identity=29.0322580645161, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=40.3846153846154, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=36.7883211678832, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI28573187, Length=254, Percent_Identity=30.7086614173228, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66884; Mature: 66884

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGEEEAPSILLEGLKRLEYRGYDSAGIAVSDGYNINVVKKAGKLKELENIVFS
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHCC
SPPAGTAGIGHTRWATHGVPSEKNSHPHYDCHENIVVVHNGIIENFQELKEGLEAAGHSF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCC
VSDTDTEVIAHLIEDYYNGDLKDAVFKAVQKLDGSYALAVMTKEEPNKIIAVRKDSPLII
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEE
GKGQGENYIASDIPAFLNNTRSFYILDDGEIAEVSKDKVVIYDKNGVSIDKEIFKVDWDP
ECCCCCCCCHHCCHHHHCCCCEEEEEECCCEEECCCCEEEEECCCCCCCCCCCEEECCCC
EMAEKNGYEHYMLKEIHEQPDALRRVLANRVSTQGVNLDEIGLTAEELKKYSQIQVVACG
CHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHCCEEEEEEC
TAYYSGMVGKYIIEELARIPVKVDVASEFRYSNPIIDKDTLVIVVSQSGETADTLAGLRL
HHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
AREKGAEVLALTNVVGSTIAREADRVLYLKAGPEIAVASTKAYLTMVSVFYLLAVQFAKI
HHHCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
KGTINDDEYMGLVSDLIRLPELASETIKVSEEKAKEKARYFIDYDNSFYIGRNFDYTIAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCEEEEECCCEEEEECCCCEEEEE
EGALKLKEISYLHAEAYPAGELKHGPLALIEEGIPVVAVVTRRSLYDKMLSNIKEVKARG
CCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
ANITAVAIAGDAEVEKAVDDVIFIPECNEFFSGLLAVIPLQLLAYYTAVGRGFDVDQPRN
CCEEEEEEECCHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGYIGEEEAPSILLEGLKRLEYRGYDSAGIAVSDGYNINVVKKAGKLKELENIVFS
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHCC
SPPAGTAGIGHTRWATHGVPSEKNSHPHYDCHENIVVVHNGIIENFQELKEGLEAAGHSF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCC
VSDTDTEVIAHLIEDYYNGDLKDAVFKAVQKLDGSYALAVMTKEEPNKIIAVRKDSPLII
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEE
GKGQGENYIASDIPAFLNNTRSFYILDDGEIAEVSKDKVVIYDKNGVSIDKEIFKVDWDP
ECCCCCCCCHHCCHHHHCCCCEEEEEECCCEEECCCCEEEEECCCCCCCCCCCEEECCCC
EMAEKNGYEHYMLKEIHEQPDALRRVLANRVSTQGVNLDEIGLTAEELKKYSQIQVVACG
CHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHCCEEEEEEC
TAYYSGMVGKYIIEELARIPVKVDVASEFRYSNPIIDKDTLVIVVSQSGETADTLAGLRL
HHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
AREKGAEVLALTNVVGSTIAREADRVLYLKAGPEIAVASTKAYLTMVSVFYLLAVQFAKI
HHHCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
KGTINDDEYMGLVSDLIRLPELASETIKVSEEKAKEKARYFIDYDNSFYIGRNFDYTIAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCEEEEECCCEEEEECCCCEEEEE
EGALKLKEISYLHAEAYPAGELKHGPLALIEEGIPVVAVVTRRSLYDKMLSNIKEVKARG
CCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
ANITAVAIAGDAEVEKAVDDVIFIPECNEFFSGLLAVIPLQLLAYYTAVGRGFDVDQPRN
CCEEEEEEECCHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]