Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 220930905

GI number: 220930905

Start: 65387

End: 65947

Strand: Direct

Name: hpt [H]

Synonym: Hore_00570

Alternate gene names: 220930905

Gene position: 65387-65947 (Clockwise)

Preceding gene: 220930904

Following gene: 220930906

Centisome position: 2.54

GC content: 38.5

Gene sequence:

>561_bases
ATGCCATCAACAAATATTATGATGAAAGATATTAAAGAAATTATTATTCCTGAAGAGGTAATCCAGAATCGCATTAAAGA
ACTTGGAGAGGAAATCAGTAACAGCTATGATCCTGAAGATGAGGTTATAATGGTCTGTATTTTGAGGGGGGCTGTTATTT
TTGCTGCTGACCTGGCCCGGCATATTAATTTGCCAGTGACTATAGACTTTATGGATGTTTCCAGTTATGGTCAGGGTACT
TCTTCCTCAGGGGTTGTCCGGATTATTAAGGACCTTGAAGAAAACATTGAAAACAAACATGTATTGATAGTTGAAGATAT
TATAGATACAGGATTAACCCTGAAACATGTGGTCGATATGCTTAAAACCCGCGAACCGGCCAGTATAAAAATTGTGACCT
TGCTGGATAAACCGGAGCGACGGGTAGAAAAACAGGTTGAGGTTGATTTTAATGGGTTTGAGGTTCCTGATAAATTTGTG
GTTGGATATGGACTTGATTATGCTGAAAAATACAGGAACCTGCCCTTTATAGGGGTGCTTAAAGAAGAACTTTATTCCTG
A

Upstream 100 bases:

>100_bases
CTGGTTAGCCGGTTTAAGGATGGATGATAGATTTAAAATTACAGATGATACCAAAAAAATAGTCAGATTTGAAATAACCA
ATAATAAGGAGGAATAAACT

Downstream 100 bases:

>100_bases
TCTGTATAGTAAAATTGCCAGTATTGTCAAATTAATTCTCTTATGATATAATTATAAATTGTTGTAATGAGATAGTTTAC
CTTGAGGGGAGGTTAACCTG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MPSTNIMMKDIKEIIIPEEVIQNRIKELGEEISNSYDPEDEVIMVCILRGAVIFAADLARHINLPVTIDFMDVSSYGQGT
SSSGVVRIIKDLEENIENKHVLIVEDIIDTGLTLKHVVDMLKTREPASIKIVTLLDKPERRVEKQVEVDFNGFEVPDKFV
VGYGLDYAEKYRNLPFIGVLKEELYS

Sequences:

>Translated_186_residues
MPSTNIMMKDIKEIIIPEEVIQNRIKELGEEISNSYDPEDEVIMVCILRGAVIFAADLARHINLPVTIDFMDVSSYGQGT
SSSGVVRIIKDLEENIENKHVLIVEDIIDTGLTLKHVVDMLKTREPASIKIVTLLDKPERRVEKQVEVDFNGFEVPDKFV
VGYGLDYAEKYRNLPFIGVLKEELYS
>Mature_185_residues
PSTNIMMKDIKEIIIPEEVIQNRIKELGEEISNSYDPEDEVIMVCILRGAVIFAADLARHINLPVTIDFMDVSSYGQGTS
SSGVVRIIKDLEENIENKHVLIVEDIIDTGLTLKHVVDMLKTREPASIKIVTLLDKPERRVEKQVEVDFNGFEVPDKFVV
GYGLDYAEKYRNLPFIGVLKEELYS

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=189, Percent_Identity=34.3915343915344, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI9910262, Length=184, Percent_Identity=34.2391304347826, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=52.9069767441861, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17510817, Length=182, Percent_Identity=34.6153846153846, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21111; Mature: 20979

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTNIMMKDIKEIIIPEEVIQNRIKELGEEISNSYDPEDEVIMVCILRGAVIFAADLAR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
HINLPVTIDFMDVSSYGQGTSSSGVVRIIKDLEENIENKHVLIVEDIIDTGLTLKHVVDM
HCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCHHHHHHHH
LKTREPASIKIVTLLDKPERRVEKQVEVDFNGFEVPDKFVVGYGLDYAEKYRNLPFIGVL
HHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHCCCCEEEHH
KEELYS
HHHHCC
>Mature Secondary Structure 
PSTNIMMKDIKEIIIPEEVIQNRIKELGEEISNSYDPEDEVIMVCILRGAVIFAADLAR
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
HINLPVTIDFMDVSSYGQGTSSSGVVRIIKDLEENIENKHVLIVEDIIDTGLTLKHVVDM
HCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCHHHHHHHH
LKTREPASIKIVTLLDKPERRVEKQVEVDFNGFEVPDKFVVGYGLDYAEKYRNLPFIGVL
HHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHCCCCEEEHH
KEELYS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]