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The map label for this gene is degA [H]

Identifier: 220930892

GI number: 220930892

Start: 50996

End: 52012

Strand: Direct

Name: degA [H]

Synonym: Hore_00440

Alternate gene names: 220930892

Gene position: 50996-52012 (Clockwise)

Preceding gene: 220930891

Following gene: 220930893

Centisome position: 1.98

GC content: 42.38

Gene sequence:

>1017_bases
TTGCCGTTGACTTTAAAGGATATTGCAAAAATAGCTGGTGTGGCCGAGTCAACGGTTTCCAGGGCCATTAATAATAAACC
CGGGGTTGGTGAAGAAACCAGAAAGAAAATCCTGAAAATTGTAGAGGAGTATAACTTTCAACCCAACAAACTGGCCCAGG
GGCTTGCCAAAAAGCAGACCCACATTCTGGCTTTATTATTACCTGATTTGTCAAATCCTAATTATCCTACGATAATTAAA
AGTATAGAGGAAGTAGCCAATGAAAATGGATACCAGGTTGTTTTGTGTAATACTGATAACAACCCGGAAAAAGAGAAAGG
CTATCTCGAATTAGTAGAGAGGAACCAGGTTGATGGGGCTATTGTGGTTGGTGGTGAACTGGCCGACAGGCATATTTTAA
ATCTGGCTTTGAATAAGAATGCCTCTCTTGTTCTGGTAAATAGGCTCTGTGAGGAGCTTACCATACCTACCGTTCTGGTT
GATTCAGCCCGGGGGGCTTACCTGGCAACTGAGCACCTGATAGACCAGGGTATCAGTGAAATTGCCCTTATAATGGGCCT
GGACCGGGAATTTTTAGAATCTGAAAAGCTTGAAGGTTATAAACAGGCTTTAACTGATAATGGTATAGAACTTAATGAAA
AATTAATTGTGCAAACAGAAGGAAGCCGGGAAGCCGGGTACAGGGCTTTTCTTGAATTAATGAAAAAGGGGGTTACCCCC
GGTGGTTTTTTTGCTACCAGTGATCTTCTGGCTGCCGGCCTGGTAGAAGCAATTAAGATGGGAGGATATTTAATTCCTGA
AGACTTTTCAGTGGTGGGTTATGGTGATAGCCTTGTGTCTTCGATAATTACCCCACCTCTGACGGTTGTGGCTGAACCAT
TGACCAGGCTTGGTAAACTGGCTGCTCGAAACCTTATTAATCTCTTAAATGGGAAACAACCTGCTGAAATTATTAAGGTA
TTAAATCCGTCCATTAAGGTGCGGAATTCATCTACACCGCACATTAAGGATAAATAA

Upstream 100 bases:

>100_bases
GAAGGAATTTTTTAATTTACATAGAATATATATTATAAAAGGAACGCAAGCACTTGCGTAAGGTTTTTCGCAAGCGGTTG
TGTAACGGGAGTGATTACTT

Downstream 100 bases:

>100_bases
AACTTCTTAAAATTAAAAGGGGGATGTATTAATGGCTAGTGTAACATTAGAGAATGTTGTTAAGAGGTTTGATGATGTAG
TTGCTGTAAACAATGCTAAT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPLTLKDIAKIAGVAESTVSRAINNKPGVGEETRKKILKIVEEYNFQPNKLAQGLAKKQTHILALLLPDLSNPNYPTIIK
SIEEVANENGYQVVLCNTDNNPEKEKGYLELVERNQVDGAIVVGGELADRHILNLALNKNASLVLVNRLCEELTIPTVLV
DSARGAYLATEHLIDQGISEIALIMGLDREFLESEKLEGYKQALTDNGIELNEKLIVQTEGSREAGYRAFLELMKKGVTP
GGFFATSDLLAAGLVEAIKMGGYLIPEDFSVVGYGDSLVSSIITPPLTVVAEPLTRLGKLAARNLINLLNGKQPAEIIKV
LNPSIKVRNSSTPHIKDK

Sequences:

>Translated_338_residues
MPLTLKDIAKIAGVAESTVSRAINNKPGVGEETRKKILKIVEEYNFQPNKLAQGLAKKQTHILALLLPDLSNPNYPTIIK
SIEEVANENGYQVVLCNTDNNPEKEKGYLELVERNQVDGAIVVGGELADRHILNLALNKNASLVLVNRLCEELTIPTVLV
DSARGAYLATEHLIDQGISEIALIMGLDREFLESEKLEGYKQALTDNGIELNEKLIVQTEGSREAGYRAFLELMKKGVTP
GGFFATSDLLAAGLVEAIKMGGYLIPEDFSVVGYGDSLVSSIITPPLTVVAEPLTRLGKLAARNLINLLNGKQPAEIIKV
LNPSIKVRNSSTPHIKDK
>Mature_337_residues
PLTLKDIAKIAGVAESTVSRAINNKPGVGEETRKKILKIVEEYNFQPNKLAQGLAKKQTHILALLLPDLSNPNYPTIIKS
IEEVANENGYQVVLCNTDNNPEKEKGYLELVERNQVDGAIVVGGELADRHILNLALNKNASLVLVNRLCEELTIPTVLVD
SARGAYLATEHLIDQGISEIALIMGLDREFLESEKLEGYKQALTDNGIELNEKLIVQTEGSREAGYRAFLELMKKGVTPG
GFFATSDLLAAGLVEAIKMGGYLIPEDFSVVGYGDSLVSSIITPPLTVVAEPLTRLGKLAARNLINLLNGKQPAEIIKVL
NPSIKVRNSSTPHIKDK

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=331, Percent_Identity=28.3987915407855, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=30.5389221556886, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790194, Length=318, Percent_Identity=31.1320754716981, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1787948, Length=329, Percent_Identity=29.1793313069909, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1788474, Length=299, Percent_Identity=28.4280936454849, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789068, Length=313, Percent_Identity=27.7955271565495, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786540, Length=315, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787580, Length=326, Percent_Identity=26.6871165644172, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786268, Length=299, Percent_Identity=27.0903010033445, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=26.537216828479, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787906, Length=305, Percent_Identity=23.9344262295082, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790715, Length=309, Percent_Identity=25.2427184466019, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789456, Length=298, Percent_Identity=28.5234899328859, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790689, Length=328, Percent_Identity=22.8658536585366, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36770; Mature: 36639

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTLKDIAKIAGVAESTVSRAINNKPGVGEETRKKILKIVEEYNFQPNKLAQGLAKKQT
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HILALLLPDLSNPNYPTIIKSIEEVANENGYQVVLCNTDNNPEKEKGYLELVERNQVDGA
HEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCE
IVVGGELADRHILNLALNKNASLVLVNRLCEELTIPTVLVDSARGAYLATEHLIDQGISE
EEECCCHHHHHHHHHEECCCCCEEHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
IALIMGLDREFLESEKLEGYKQALTDNGIELNEKLIVQTEGSREAGYRAFLELMKKGVTP
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECCEEEEEECCCCHHHHHHHHHHHHHCCCC
GGFFATSDLLAAGLVEAIKMGGYLIPEDFSVVGYGDSLVSSIITPPLTVVAEPLTRLGKL
CCCHHHHHHHHHHHHHHHHHCCEECCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHH
AARNLINLLNGKQPAEIIKVLNPSIKVRNSSTPHIKDK
HHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
PLTLKDIAKIAGVAESTVSRAINNKPGVGEETRKKILKIVEEYNFQPNKLAQGLAKKQT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HILALLLPDLSNPNYPTIIKSIEEVANENGYQVVLCNTDNNPEKEKGYLELVERNQVDGA
HEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCE
IVVGGELADRHILNLALNKNASLVLVNRLCEELTIPTVLVDSARGAYLATEHLIDQGISE
EEECCCHHHHHHHHHEECCCCCEEHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
IALIMGLDREFLESEKLEGYKQALTDNGIELNEKLIVQTEGSREAGYRAFLELMKKGVTP
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECCEEEEEECCCCHHHHHHHHHHHHHCCCC
GGFFATSDLLAAGLVEAIKMGGYLIPEDFSVVGYGDSLVSSIITPPLTVVAEPLTRLGKL
CCCHHHHHHHHHHHHHHHHHCCEECCCCCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHH
AARNLINLLNGKQPAEIIKVLNPSIKVRNSSTPHIKDK
HHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]