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The map label for this gene is icd2 [H]

Identifier: 221230919

GI number: 221230919

Start: 3210516

End: 3212756

Strand: Reverse

Name: icd2 [H]

Synonym: MLBr_02672

Alternate gene names: 221230919

Gene position: 3212756-3210516 (Counterclockwise)

Preceding gene: 221230923

Following gene: 221230917

Centisome position: 98.31

GC content: 56.98

Gene sequence:

>2241_bases
ATGAGCGCCGAGCAGTGGACCATCATCTACACGCTGACCGACGAGGCGCCGCTGTTAGCGACCTACGCCTTTCTACCGAT
AGTGCGTGCCTTTACCAAGCCCGCGGGTATTAAGGTCCAGACTAGCGACATCTCCGTGGCAGCACGCATACTGGCCGAGT
TTCCCGATTACCTGACCGAAGAGCAACGTGTGCCGAACAACCTTGCCGAACTGGGCCGGTTGACACAGTTACCGGACACC
AACATCATCAAGCTGCCGAACATCAGTGCTTCGGTGCCGCAATTGATGGCCGCCATCAAGGAGTTGCAGGCCAAGGGATT
CAAGCTTCCAGACTATCCGCAAGATCCGAAGTCCTACCAGGAAATCGACATCCGTAACCGCTACGGTAAATGCCTTGGCA
GCGCCGTGAACCCGGTTTTGCGGGAAGGTAACTCCGACCGTCGTGCACCTAAGGCTGTGAAGGAGTACGCACGTAACAAC
CCGCACAGCATGGGCGAATGGTCGATGGCTTCGCGCACACACGTCGCGACCATGCGGCACGGCGACTTCTATCACGGCGA
GAAGTCGATGACTTTAGACCGCGCGCGAGACGTGAAGATGGAGCTGGCAACCAAGAAAGGCAAAATAGTCGTGCTCAAGC
CCAAGGTGTCGCTACGGGACGGCGACATCATCGACAGCATGTTCATGAGCAAGAAAGCCCTGTGCGAATTCTACGAGGAG
CAGATGGAGGATGCTCGCAAGACCGGCGTGATGTTCTCACTGCACGTTAAAGCGACGATGATGAAAGTGTCTCATCCTAT
CGTTTTCGGCCACGCGGTGAAAACCTTTTACAAGGAAGCCTTCGCCAAGCACCAGGATCTGTTCGACGAACTGGGCGTAA
ACGTCAACAACGGGTTAGTCGATCTCTATAGCAAGATTGAGACCCTGACCGCATCGCAGCGCGATGAGATCATCCAAGAC
CTACATGCGTGCCACGAGCACCGACCCGAGTTGGCTATGGTCGACTCAGCGCGTGGAATTTCGAACTTCTATTCGCCTAG
TGATGTCATCGTGGATGCGTCGATGCCAGCGATGATCCGTGCGGGAGGCAAGATGTATGGCGCCGACGGGCGGGCCAAGG
ACACCAAGGCCGTGAACCCCGAGTCCACCTTTTCCCGCATCTACCAGGAAATCATCAACTTCTGCAAGACCAACGGAGCT
TTCGATCCGGCGACTATGGGCACCGTCCCCAACGTTGGCCTCATGGCGCAACAGGCTGAGGAGTACGGCTCGCACGACAA
GACATTCGAAATTCCCGAGGACGGCGTCGCCAACATCGTGGACCTCACGACGGGCGAAGTGCTGCTGACCCAGAATGTAG
AAACCGGTGATATATGGCGTCTATGCGTCGTTACCGACGCAGCAATTCGCGACTGGGTCAAGCTGGCTGTCAGCCGTATG
CGCAACTCCGGCATGCCAGTATTGTTTTGGTTGGACCCTTACCGTCCACACGAGAATGAGTTGATCAAAAAGGTCCGGGC
GTACCTGAAGGACCACGACACCAGTGGCCTGGATATCCAGATCATGTCGCAAGTGCGCTCAATGCGTTACACGTGCGAGC
GCCTCATCCGCGGGCTAGATACCATCGCCGCCACTGGCAACATCCTGCGGGACTACCTCACCGATCTGTTCCCGATCTTG
GAGTTAGGTACCAGCGCCAAAATGTTGTCCATAGTGCCGCTAATGGCCGGTGGCGGGATGTATGAAACCGGGGCGGGTGG
ATCGGCGCCCAAGCACGTCAAGCAGCTTGTCGAAGAGAATCATCTGCGGTGGGACTCGCTGGGTGAGTTCCTCGCGCTGG
CCGTCAGCCTGGAAGACCTGGGCATCAAGACCGGCAATGAGAGGGCCAAAATCTTGGCTAAGACGCTGGATGTCGCAACC
GGAAAGTTGCTGGACAACAGGAAGAGTCCGTCACGCAAGGCCGGTGAGCTCGACAACCGTGGAAGCCAGTTCTACCTCGC
CATGTACTGGGCTCAAGAGCTTGCCACGCAAACCGATGACCAACATCTGCGGAACTACTTCACCCCACTGGCCGAAACGT
TGGCCAAGAACGAATGCACTATCGTCGCCGAGCTCAACGAGGCTCAAGGCAAGGCGGTCGATATCGGTGGTTACTACGCA
CCGGATGCTGAGCTGGCCAAGGCGGTGATGCGTCCGAGTGCCGTGTTCAATGCTGCGTTGGCGGCTGCTCAAGGTAGTTA
A

Upstream 100 bases:

>100_bases
CGCGCGCTTGCTACGCATGTTGGAGCCGCGATACTAAATAGCCGCCGTTATAACGCAGAGCCCTCAACATCTGACCAACA
GTTACGCTGGGAGAACAATC

Downstream 100 bases:

>100_bases
AGGCCCCCCACTTTTCGTCCTGTGTGTCACTGTTACTGACGTGCGAGTTCTCCTATCGAAATACGAGTCGTGGGCAACAC
CAGCGACTGGCTGTAGTGAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH-II; IDP-2; NADP+-specific ICDH 2; Oxalosuccinate decarboxylase 2 [H]

Number of amino acids: Translated: 746; Mature: 745

Protein sequence:

>746_residues
MSAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAGIKVQTSDISVAARILAEFPDYLTEEQRVPNNLAELGRLTQLPDT
NIIKLPNISASVPQLMAAIKELQAKGFKLPDYPQDPKSYQEIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNN
PHSMGEWSMASRTHVATMRHGDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALCEFYEE
QMEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNVNNGLVDLYSKIETLTASQRDEIIQD
LHACHEHRPELAMVDSARGISNFYSPSDVIVDASMPAMIRAGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGA
FDPATMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKLAVSRM
RNSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERLIRGLDTIAATGNILRDYLTDLFPIL
ELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNERAKILAKTLDVAT
GKLLDNRKSPSRKAGELDNRGSQFYLAMYWAQELATQTDDQHLRNYFTPLAETLAKNECTIVAELNEAQGKAVDIGGYYA
PDAELAKAVMRPSAVFNAALAAAQGS

Sequences:

>Translated_746_residues
MSAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAGIKVQTSDISVAARILAEFPDYLTEEQRVPNNLAELGRLTQLPDT
NIIKLPNISASVPQLMAAIKELQAKGFKLPDYPQDPKSYQEIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNN
PHSMGEWSMASRTHVATMRHGDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALCEFYEE
QMEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNVNNGLVDLYSKIETLTASQRDEIIQD
LHACHEHRPELAMVDSARGISNFYSPSDVIVDASMPAMIRAGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGA
FDPATMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKLAVSRM
RNSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERLIRGLDTIAATGNILRDYLTDLFPIL
ELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNERAKILAKTLDVAT
GKLLDNRKSPSRKAGELDNRGSQFYLAMYWAQELATQTDDQHLRNYFTPLAETLAKNECTIVAELNEAQGKAVDIGGYYA
PDAELAKAVMRPSAVFNAALAAAQGS
>Mature_745_residues
SAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAGIKVQTSDISVAARILAEFPDYLTEEQRVPNNLAELGRLTQLPDTN
IIKLPNISASVPQLMAAIKELQAKGFKLPDYPQDPKSYQEIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNNP
HSMGEWSMASRTHVATMRHGDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALCEFYEEQ
MEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNVNNGLVDLYSKIETLTASQRDEIIQDL
HACHEHRPELAMVDSARGISNFYSPSDVIVDASMPAMIRAGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGAF
DPATMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKLAVSRMR
NSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERLIRGLDTIAATGNILRDYLTDLFPILE
LGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALAVSLEDLGIKTGNERAKILAKTLDVATG
KLLDNRKSPSRKAGELDNRGSQFYLAMYWAQELATQTDDQHLRNYFTPLAETLAKNECTIVAELNEAQGKAVDIGGYYAP
DAELAKAVMRPSAVFNAALAAAQGS

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82763; Mature: 82631

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAGIKVQTSDISVAARILAEFPDYLTE
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
EQRVPNNLAELGRLTQLPDTNIIKLPNISASVPQLMAAIKELQAKGFKLPDYPQDPKSYQ
HHCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
EIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNNPHSMGEWSMASRTHVATMRH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEC
GDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALCEFYEE
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
QMEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNVNNGLV
HHHHHHHHCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYSKIETLTASQRDEIIQDLHACHEHRPELAMVDSARGISNFYSPSDVIVDASMPAMIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCCEEEECCCCHHHH
AGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGAFDPATMGTVPNVGLMAQQAE
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKLAVSRM
HHCCCCCEEECCCCCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
RNSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERLIRGLD
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVKQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEDLGIKTGNERAKILAKTLDVATGKLLDNRKSPSRKAGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSQFYLAMYWAQELATQTDDQHLRNYFTPLAETLAKNECTIVAELNEAQGKAVDIGGYYA
CCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCEEC
PDAELAKAVMRPSAVFNAALAAAQGS
CCHHHHHHHHCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAGIKVQTSDISVAARILAEFPDYLTE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHH
EQRVPNNLAELGRLTQLPDTNIIKLPNISASVPQLMAAIKELQAKGFKLPDYPQDPKSYQ
HHCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
EIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNNPHSMGEWSMASRTHVATMRH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEC
GDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALCEFYEE
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
QMEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNVNNGLV
HHHHHHHHCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYSKIETLTASQRDEIIQDLHACHEHRPELAMVDSARGISNFYSPSDVIVDASMPAMIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCCEEEECCCCHHHH
AGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGAFDPATMGTVPNVGLMAQQAE
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKLAVSRM
HHCCCCCEEECCCCCCCCEEECCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
RNSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERLIRGLD
HCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVKQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEDLGIKTGNERAKILAKTLDVATGKLLDNRKSPSRKAGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSQFYLAMYWAQELATQTDDQHLRNYFTPLAETLAKNECTIVAELNEAQGKAVDIGGYYA
CCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCEEC
PDAELAKAVMRPSAVFNAALAAAQGS
CCHHHHHHHHCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226630; 1295895 [H]