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The map label for this gene is fbpC2

Identifier: 221230909

GI number: 221230909

Start: 3177682

End: 3178683

Strand: Direct

Name: fbpC2

Synonym: MLBr_02655

Alternate gene names: 221230909

Gene position: 3177682-3178683 (Clockwise)

Preceding gene: 221230908

Following gene: 221230913

Centisome position: 97.23

GC content: 56.79

Gene sequence:

>1002_bases
ATGAAGTTCTTGCAGCAGATGCGAAAGTTGTTTGGCCTGGCGGCAAAGTTTCCGGCACGGCTGACCATCGCAGTTATAGG
GACTGCCCTGTTGGCCGGCCTTGTCGGTGTCGTCGGCGACACGGCTATAGCAGTAGCGTTTTCTAAGCCGGGTCTTCCAG
TGGAATATCTGCAGGTGCCATCACCGTCTATGGGCCATGACATCAAGATCCAGTTCCAGGGCGGCGGGCAACATGCAGTG
TACCTGCTCGACGGGCTCCGGGCCCAAGAAGATTACAACGGTTGGGACATAAACACCCCGGCTTTCGAGGAATATTACCA
TTCCGGCTTATCGGTGATCATGCCGGTCGGCGGACAGTCTAGCTTCTACAGCAACTGGTACCAACCGTCGCAAGGAAACG
GTCAGCACTACACCTACAAATGGGAGACGTTCTTAACCCAAGAAATGCCCTCGTGGCTACAAGCCAACAAGAACGTGTTA
CCGACCGGTAACGCGGCGGTGGGCCTGTCGATGTCGGGCAGTTCCGCACTAATCCTGGCCTCGTACTACCCGCAGCAGTT
CCCCTACGCCGCCTCGTTGTCGGGCTTCCTCAACCCATCCGAGGGCTGGTGGCCGACAATGATCGGCTTGGCGATGAACG
ACTCGGGCGGCTATAACGCAAACAGCATGTGGGGCCCGTCCACGGACCCGGCATGGAAGCGCAACGACCCGATGGTGCAG
ATTCCACGGCTTGTCGCCAACAACACTCGGATCTGGGTGTACTGCGGTAACGGCGCACCAAACGAACTTGGCGGCGACAA
CATACCGGCGAAATTCCTGGAAAGCCTCACGCTAAGCACCAACGAAATATTCCAGAACACCTACGCAGCCTCGGGCGGAC
GCAACGGAGTGTTCAATTTCCCACCCAACGGAACACACTCGTGGCCGTACTGGAATCAACAACTGGTTGCCATGAAACCC
GACATCCAGCAAATACTCAACGGCAGTAACAACAATGCCTGA

Upstream 100 bases:

>100_bases
GCCGCAGCAGCCGATTCAGCCGCGACCCCTATGTTTAAATCGCCCAGGACAAATTCAACCGCATCATGCGGCAGTATGGA
AGTTGGGATGGGTAGAAGCC

Downstream 100 bases:

>100_bases
TACCATCTAACCCGCAAACCAAACAACAACCCGAGGCGCTAGGACAACAGAGCACGATGACAAGAGTGAAAGTAGGCACA
GCCCAGTAGGCACCACGCAC

Product: secreted antigen 85A, mycolyltransferase

Products: NA

Alternate protein names: Antigen 85 complex C; 85C; Ag85C; Fibronectin-binding protein C; Mycolyl transferase 85C

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKFLQQMRKLFGLAAKFPARLTIAVIGTALLAGLVGVVGDTAIAVAFSKPGLPVEYLQVPSPSMGHDIKIQFQGGGQHAV
YLLDGLRAQEDYNGWDINTPAFEEYYHSGLSVIMPVGGQSSFYSNWYQPSQGNGQHYTYKWETFLTQEMPSWLQANKNVL
PTGNAAVGLSMSGSSALILASYYPQQFPYAASLSGFLNPSEGWWPTMIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQ
IPRLVANNTRIWVYCGNGAPNELGGDNIPAKFLESLTLSTNEIFQNTYAASGGRNGVFNFPPNGTHSWPYWNQQLVAMKP
DIQQILNGSNNNA

Sequences:

>Translated_333_residues
MKFLQQMRKLFGLAAKFPARLTIAVIGTALLAGLVGVVGDTAIAVAFSKPGLPVEYLQVPSPSMGHDIKIQFQGGGQHAV
YLLDGLRAQEDYNGWDINTPAFEEYYHSGLSVIMPVGGQSSFYSNWYQPSQGNGQHYTYKWETFLTQEMPSWLQANKNVL
PTGNAAVGLSMSGSSALILASYYPQQFPYAASLSGFLNPSEGWWPTMIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQ
IPRLVANNTRIWVYCGNGAPNELGGDNIPAKFLESLTLSTNEIFQNTYAASGGRNGVFNFPPNGTHSWPYWNQQLVAMKP
DIQQILNGSNNNA
>Mature_333_residues
MKFLQQMRKLFGLAAKFPARLTIAVIGTALLAGLVGVVGDTAIAVAFSKPGLPVEYLQVPSPSMGHDIKIQFQGGGQHAV
YLLDGLRAQEDYNGWDINTPAFEEYYHSGLSVIMPVGGQSSFYSNWYQPSQGNGQHYTYKWETFLTQEMPSWLQANKNVL
PTGNAAVGLSMSGSSALILASYYPQQFPYAASLSGFLNPSEGWWPTMIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQ
IPRLVANNTRIWVYCGNGAPNELGGDNIPAKFLESLTLSTNEIFQNTYAASGGRNGVFNFPPNGTHSWPYWNQQLVAMKP
DIQQILNGSNNNA

Specific function: Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintain

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Secreted

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial A85 antigen family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): A85C_MYCLE (Q05862)

Other databases:

- EMBL:   Z21951
- EMBL:   M90649
- EMBL:   AL583926
- PIR:   S32114
- RefSeq:   NP_302695.1
- ProteinModelPortal:   Q05862
- SMR:   Q05862
- EnsemblBacteria:   EBMYCT00000028665
- GeneID:   910842
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2655
- NMPDR:   fig|272631.1.peg.1567
- Leproma:   ML2655
- GeneTree:   EBGT00050000015316
- HOGENOM:   HBG564791
- OMA:   YLDVFSP
- BioCyc:   MLEP272631:ML2655-MONOMER
- InterPro:   IPR000801

Pfam domain/function: PF00756 Esterase

EC number: NA

Molecular weight: Translated: 36392; Mature: 36392

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: ACT_SITE 170-170 ACT_SITE 274-274 ACT_SITE 306-306

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLQQMRKLFGLAAKFPARLTIAVIGTALLAGLVGVVGDTAIAVAFSKPGLPVEYLQVP
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECC
SPSMGHDIKIQFQGGGQHAVYLLDGLRAQEDYNGWDINTPAFEEYYHSGLSVIMPVGGQS
CCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCC
SFYSNWYQPSQGNGQHYTYKWETFLTQEMPSWLQANKNVLPTGNAAVGLSMSGSSALILA
CHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEE
SYYPQQFPYAASLSGFLNPSEGWWPTMIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQ
ECCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
IPRLVANNTRIWVYCGNGAPNELGGDNIPAKFLESLTLSTNEIFQNTYAASGGRNGVFNF
ECHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEC
PPNGTHSWPYWNQQLVAMKPDIQQILNGSNNNA
CCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCC
>Mature Secondary Structure
MKFLQQMRKLFGLAAKFPARLTIAVIGTALLAGLVGVVGDTAIAVAFSKPGLPVEYLQVP
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECC
SPSMGHDIKIQFQGGGQHAVYLLDGLRAQEDYNGWDINTPAFEEYYHSGLSVIMPVGGQS
CCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCC
SFYSNWYQPSQGNGQHYTYKWETFLTQEMPSWLQANKNVLPTGNAAVGLSMSGSSALILA
CHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEE
SYYPQQFPYAASLSGFLNPSEGWWPTMIGLAMNDSGGYNANSMWGPSTDPAWKRNDPMVQ
ECCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
IPRLVANNTRIWVYCGNGAPNELGGDNIPAKFLESLTLSTNEIFQNTYAASGGRNGVFNF
ECHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEC
PPNGTHSWPYWNQQLVAMKPDIQQILNGSNNNA
CCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8359887; 11234002