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The map label for this gene is msrA

Identifier: 221230905

GI number: 221230905

Start: 3166734

End: 3167267

Strand: Direct

Name: msrA

Synonym: MLBr_02647

Alternate gene names: 221230905

Gene position: 3166734-3167267 (Clockwise)

Preceding gene: 221230896

Following gene: 221230907

Centisome position: 96.9

GC content: 56.74

Gene sequence:

>534_bases
ATGGCAAGGACAAACACCCGAAAAGCGATCCTCGCCGGCGGCTGTTTCTGGGGAATCCAAAATTTGTTCCGCCGACAACC
CGGTGTGATATCGACCCGGGTTGGCTATACTGGCGGCGGCACACCCAACGCGACATACCGTAATCACGGCATGCACGCCG
AGGCGGTCGAAATCATCTATGACCCAGCGATCACTGATTATCGCACACTATTGGAATTTTTCTTCCAAATCCACGATCCG
ACAACACGAAATCGGCAAGGAAACGACCAGGGTACCAGCTACCGGTCGGCCATCTTCTACCTCGACGACGAACAAAAGAA
AGTTGCGCTGGACACCATAGCCGCCGTCGAGGCTTCCAGCCTATGGCCTGGCAAAGTAGTGACCGAGGTCAGCCTCGCTG
AGGACTTCTGGGAGGCCGAGCCTGAGCACCAGGATTACCTGCAGCACTATCCCAACGGGTACACCTGCCACTTCGTTCGT
CCCAACTGGAAGTTGCCACGACGAGCCCCCGCAGACGCAAAAGCCGACAGCTGA

Upstream 100 bases:

>100_bases
TTTCCGAATGCCGTTACATCTCATTCGTCTGAGTGTAACCTGGCTAGGGACCGTCATCGGCCCCAGGCACCATCGCTGGT
AAAGCCAACAGGGAGAGTCA

Downstream 100 bases:

>100_bases
TCGGCTAGGACCCCAGGCGGTCAGCGTTGACGCAGGATCCACTCGCCCGCCATTTCTTGGGGTGTAGACTACCCCGCGCA
AGTGCTATCGTTCACCAGGC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MARTNTRKAILAGGCFWGIQNLFRRQPGVISTRVGYTGGGTPNATYRNHGMHAEAVEIIYDPAITDYRTLLEFFFQIHDP
TTRNRQGNDQGTSYRSAIFYLDDEQKKVALDTIAAVEASSLWPGKVVTEVSLAEDFWEAEPEHQDYLQHYPNGYTCHFVR
PNWKLPRRAPADAKADS

Sequences:

>Translated_177_residues
MARTNTRKAILAGGCFWGIQNLFRRQPGVISTRVGYTGGGTPNATYRNHGMHAEAVEIIYDPAITDYRTLLEFFFQIHDP
TTRNRQGNDQGTSYRSAIFYLDDEQKKVALDTIAAVEASSLWPGKVVTEVSLAEDFWEAEPEHQDYLQHYPNGYTCHFVR
PNWKLPRRAPADAKADS
>Mature_176_residues
ARTNTRKAILAGGCFWGIQNLFRRQPGVISTRVGYTGGGTPNATYRNHGMHAEAVEIIYDPAITDYRTLLEFFFQIHDPT
TRNRQGNDQGTSYRSAIFYLDDEQKKVALDTIAAVEASSLWPGKVVTEVSLAEDFWEAEPEHQDYLQHYPNGYTCHFVRP
NWKLPRRAPADAKADS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=40, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=40, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI208609993, Length=117, Percent_Identity=39.3162393162393, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=47.3333333333333, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=139, Percent_Identity=37.410071942446, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=35.5421686746988, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=38.2978723404255, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.9705882352941, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.8794326241135, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_MYCLB (B8ZTJ5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002504321.1
- ProteinModelPortal:   B8ZTJ5
- SMR:   B8ZTJ5
- EnsemblBacteria:   EBMYCT00000086164
- GeneID:   7327123
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017224
- HOGENOM:   HBG748152
- OMA:   VPNATYR
- ProtClustDB:   PRK14054
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 20055; Mature: 19923

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: ACT_SITE 15-15

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTNTRKAILAGGCFWGIQNLFRRQPGVISTRVGYTGGGTPNATYRNHGMHAEAVEIIY
CCCCCCCEEEEECHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHEEEEE
DPAITDYRTLLEFFFQIHDPTTRNRQGNDQGTSYRSAIFYLDDEQKKVALDTIAAVEASS
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCC
LWPGKVVTEVSLAEDFWEAEPEHQDYLQHYPNGYTCHFVRPNWKLPRRAPADAKADS
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARTNTRKAILAGGCFWGIQNLFRRQPGVISTRVGYTGGGTPNATYRNHGMHAEAVEIIY
CCCCCCEEEEECHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHEEEEE
DPAITDYRTLLEFFFQIHDPTTRNRQGNDQGTSYRSAIFYLDDEQKKVALDTIAAVEASS
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCC
LWPGKVVTEVSLAEDFWEAEPEHQDYLQHYPNGYTCHFVRPNWKLPRRAPADAKADS
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA