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The map label for this gene is uppS [C]

Identifier: 221230812

GI number: 221230812

Start: 2940802

End: 2941590

Strand: Direct

Name: uppS [C]

Synonym: MLBr_02467

Alternate gene names: 221230812

Gene position: 2940802-2941590 (Clockwise)

Preceding gene: 221230811

Following gene: 221230815

Centisome position: 89.99

GC content: 60.46

Gene sequence:

>789_bases
GTGGAGATCATTCCGCCACGGCTCAAAGAGCCATTGTATGCGCTCTATGAGTTGCGGCTGCGACAGGGTCTGACAGCCTC
GGAATCCCGACTTCCTCGCCACATCGCGGTCCTGTGTGACGGAAACCGGCGGTGGGCCCGCGACGCTGGATACGACGATG
TCAGCTACGGCTACCGGATGGGCGCGGCCAAGATCGCTGAAATGCTGCGGTGGTGCCAAGAAGCCGGCATCGAAATGACC
ACGGTCTATCTGCTATCCACGGAAAACTTGCAACGCGATCCCGATGAGCTGGCCGCACTAATCGAGATCATCACTGATGT
GGTTGAGGAAATCTGCGCACCTGCCAATCGCTGGAGTGTGCGTACCGTCGGTGATTTGGAACTACTTGGCGAGGAACCAG
CCTGTCGACTGCGCGGCGCGGTGGAATCCACACCAGGTGTAGCGCCGTTCCATGTCAATGTCGCGGTGGGTTACGGAGGT
CGCCGCGAGATAGTCGGCGCGGTACGTGCGTTGTTGGGCAAGGAACTCGCCAACGGGGCCACTGCCGAGGAGCTTGTCGA
GGCGGTGACCGTTGAAGGCATTGCCAGGAACCTGTATACCTCTGGCCAACCTGACCCCGATCTGGTGATCCGCACCTCAG
GGGAGCAACGCCTGTCCGGGTTTTTGCTGTGGCAGAGTGCGTATTCAGAGATGTGGTTCACCGAAACGCACTGGCCCGCA
TTCCGGCGGGTCGATTTCCTGCGCGCGCTGCGCGATTACAGCATGAGGCACCGTCGGTACGGCAAGTAG

Upstream 100 bases:

>100_bases
TGAATCCCAGTAACCTGGCACGTTTATCGCACAGACCCGACGTGATATAGCAGGAAATGCAGACCGGACTTTGTTGCTTG
TCACAGTAGGGTAGATGTTC

Downstream 100 bases:

>100_bases
CGGCCGGCGGCGAAGGTCTTAGTCAGTGGGGGCACAAGTGACACAACCTATGCGTGATTGCGCTGTCAGTGGTTGTATTC
ACGCTCAGCGGGTGGCTAGG

Product: putative undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMT
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANRWSVRTVGDLELLGEEPACRLRGAVESTPGVAPFHVNVAVGYGG
RREIVGAVRALLGKELANGATAEELVEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHWPA
FRRVDFLRALRDYSMRHRRYGK

Sequences:

>Translated_262_residues
MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMT
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANRWSVRTVGDLELLGEEPACRLRGAVESTPGVAPFHVNVAVGYGG
RREIVGAVRALLGKELANGATAEELVEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHWPA
FRRVDFLRALRDYSMRHRRYGK
>Mature_262_residues
MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDGNRRWARDAGYDDVSYGYRMGAAKIAEMLRWCQEAGIEMT
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANRWSVRTVGDLELLGEEPACRLRGAVESTPGVAPFHVNVAVGYGG
RREIVGAVRALLGKELANGATAEELVEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHWPA
FRRVDFLRALRDYSMRHRRYGK

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=233, Percent_Identity=34.3347639484979, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI45580742, Length=233, Percent_Identity=34.3347639484979, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=34.6320346320346, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71993029, Length=233, Percent_Identity=29.1845493562232, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=33.4862385321101, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=25.9090909090909, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.68 [H]

Molecular weight: Translated: 29528; Mature: 29528

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDGNRRWARDAGYDDVSYGYRM
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
GAAKIAEMLRWCQEAGIEMTTVYLLSTENLQRDPDELAALIEIITDVVEEICAPANRWSV
HHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
RTVGDLELLGEEPACRLRGAVESTPGVAPFHVNVAVGYGGRREIVGAVRALLGKELANGA
EECCCHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TAEELVEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHWPA
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHH
FRRVDFLRALRDYSMRHRRYGK
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIIPPRLKEPLYALYELRLRQGLTASESRLPRHIAVLCDGNRRWARDAGYDDVSYGYRM
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
GAAKIAEMLRWCQEAGIEMTTVYLLSTENLQRDPDELAALIEIITDVVEEICAPANRWSV
HHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
RTVGDLELLGEEPACRLRGAVESTPGVAPFHVNVAVGYGGRREIVGAVRALLGKELANGA
EECCCHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TAEELVEAVTVEGIARNLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTETHWPA
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHH
FRRVDFLRALRDYSMRHRRYGK
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]