Click here to switch to the map view.

The map label for this gene is dnaZX [H]

Identifier: 221230735

GI number: 221230735

Start: 2765632

End: 2767467

Strand: Reverse

Name: dnaZX [H]

Synonym: MLBr_02335

Alternate gene names: 221230735

Gene position: 2767467-2765632 (Counterclockwise)

Preceding gene: 221230736

Following gene: 221230732

Centisome position: 84.68

GC content: 62.69

Gene sequence:

>1836_bases
GTGACTCTGTACCGCAAGTATCGACCGGCAGCTTTCGCTGAGGTGGTGGGGCAAGAACATGTCACCGAGCCGCTGTCTAT
CGCTTTGGAAGCCGGAAGGATCAACCATGCTTACTTGTTCTCCGGGCCGCGTGGCTGTGGAAAGACCTCTTCGGCGCGCA
TTCTGGCGCGGTCGCTTAATTGTGCGCAGGGGACCACGGCCACGCCGTGTGGTGTATGCGAATCATGCTTGTCTTTGGCG
CCCAACGCGCCCGGCCACATCGACGTGGTGGAGCTTGACGCCGCCAGCCACGGCGGCGTGGACGACACTCGTGAGCTGCG
CGACCGCGCGTTCTACGCGCCGGCCCAGTCACGGTACCGTGTGTTCATTGTCGACGAAGCGCACATGGTGACCACCGCCG
GCTTTAACGCGCTACTCAAGATCGTCGAGGAACCGCCCGACCACTTGATCTTCATCTTCGCCACCACCGAGCCGGAGAAG
GTGCTGCCGACGATTCGATCGCGCACCCATCATTACCCATTTAGGCTGCTGTCGCCACGCACCATGCGGGCTTTGGTCGG
GCGCATCTGTGCGCAGGAGGGCGTCGTCGTCGACGATGCGGTGTACCCTCTGGTCATCCGGGCCGGTGGAGGTTCCCCCC
GGGACACGCTGTCAGTGTTGGATCAGCTGGTGGCTGGCGCGGAAGGCGAGCACGTGACCTACCAGCGGGCGCTGAAGTTG
CTAGGTGCCACCGACGTTGGACTTATAGACGACGCTGTCGATGCACTCGGGGCTCACGATGCGGCAGCATTGTTTGGTGC
GGTCGAATCGGTGATTGATGCCGGCCACGATCCACGGCGTTTTGCTACTGATTTGCTAGAGCGATTCCGCGATCTCATCG
TCCTGCAGGCGGTTCCTGATGCGGCAGCCCGTGGTGTGGTGGATGCTTCGGAGGATGTGTTAGACCGGATGCGGGAGCAA
GCTGTCCGAATCGGACCGGCGACGTTGACCCGTTACGCCGAGGTGGTACACTCCGGGTTGGGGGAGATGCGTGGTGCAAC
GGCGCCGCGTCTGCTTCTCGAAGTGGTTTGCGCGCGGCTGTTGCTGCCTTCGGCCACGGACGCCGAGTCGGCATTGCTGC
AACGGGTCGAGCGAATCGAGACCCGGCTGAACATGTCGATCCCCGCTGCCAGGGCAGCATACCCGCTTCAGTCAGCGCCC
GCCGAGAAGGCTGCCCAACCTAGTCTCCCTCACCAGCCTTTCCTGGCTTCCCCGGATTCCCAGCCCGCTCCGGATGCTCA
GTCTTCCAAACTGGCTACGCCACAGGCTGCCGCTGAACCAACCCCTGGCATGGGTGCACCCAATGCGGCCGCGGTACGAA
CCATGTGGTCGACGGTGCGTGAGAAGGTGCGCCAGCGCAGCCGCACTACCGAGGTGATGCTGGCGGGCGCGACCGTCCGC
GCGGTTGAGGACAACACCTTGATTTTGACCCACGGATCGGCGCCACTGGCCAAGCGGCTGTCTGAACAGCACAACGTAGA
TGTTATCGCCGAAGCGCTCAAAGACGCGCTGGGTGTGAACTGGCGGGTGCGATGCGAGGCCGGCGTACCCGTGCCTGCTG
TGGGTGCACTACCCGCTTGCGAGGGAATGGTTGCGCTGCCTACCCAGGAGAAAGTTCCTGTCCTTGACGTGGCTTCTGCC
CAGCAGTATGAAGATGAGGGCATGCTAGCTGAACCCGGGCGTAGAGACCTGTCAGCACCGCGTCCCGACCTGGAAGAGGT
TGCGCTCGAACTGTTGCAAAACGAACTGGGTGCCCGCCGTATCGATAAATGGCTGACTGACGCGGTTGAAGACTAA

Upstream 100 bases:

>100_bases
GGTCGGCCGGTCGTTAGTCAGCGGTTCGGCTTGACCGGCCCGCCCCTTAGGCGGACCCTCCGGGGTTCGCATCGTCATTG
GACCTGAGTAGCCTGCTGAC

Downstream 100 bases:

>100_bases
GGTGTCCACCAAGGCCGTGTCGGTAGGCTGTTGTCACCCCAGACGTCAACCTTTGTCGCCAGTATGTGATGCAGCTGGAG
GTTGTTTTGTTCAAAAGCCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MTLYRKYRPAAFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGTTATPCGVCESCLSLA
PNAPGHIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPDHLIFIFATTEPEK
VLPTIRSRTHHYPFRLLSPRTMRALVGRICAQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGEHVTYQRALKL
LGATDVGLIDDAVDALGAHDAAALFGAVESVIDAGHDPRRFATDLLERFRDLIVLQAVPDAAARGVVDASEDVLDRMREQ
AVRIGPATLTRYAEVVHSGLGEMRGATAPRLLLEVVCARLLLPSATDAESALLQRVERIETRLNMSIPAARAAYPLQSAP
AEKAAQPSLPHQPFLASPDSQPAPDAQSSKLATPQAAAEPTPGMGAPNAAAVRTMWSTVREKVRQRSRTTEVMLAGATVR
AVEDNTLILTHGSAPLAKRLSEQHNVDVIAEALKDALGVNWRVRCEAGVPVPAVGALPACEGMVALPTQEKVPVLDVASA
QQYEDEGMLAEPGRRDLSAPRPDLEEVALELLQNELGARRIDKWLTDAVED

Sequences:

>Translated_611_residues
MTLYRKYRPAAFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGTTATPCGVCESCLSLA
PNAPGHIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPDHLIFIFATTEPEK
VLPTIRSRTHHYPFRLLSPRTMRALVGRICAQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGEHVTYQRALKL
LGATDVGLIDDAVDALGAHDAAALFGAVESVIDAGHDPRRFATDLLERFRDLIVLQAVPDAAARGVVDASEDVLDRMREQ
AVRIGPATLTRYAEVVHSGLGEMRGATAPRLLLEVVCARLLLPSATDAESALLQRVERIETRLNMSIPAARAAYPLQSAP
AEKAAQPSLPHQPFLASPDSQPAPDAQSSKLATPQAAAEPTPGMGAPNAAAVRTMWSTVREKVRQRSRTTEVMLAGATVR
AVEDNTLILTHGSAPLAKRLSEQHNVDVIAEALKDALGVNWRVRCEAGVPVPAVGALPACEGMVALPTQEKVPVLDVASA
QQYEDEGMLAEPGRRDLSAPRPDLEEVALELLQNELGARRIDKWLTDAVED
>Mature_610_residues
TLYRKYRPAAFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGTTATPCGVCESCLSLAP
NAPGHIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPDHLIFIFATTEPEKV
LPTIRSRTHHYPFRLLSPRTMRALVGRICAQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGEHVTYQRALKLL
GATDVGLIDDAVDALGAHDAAALFGAVESVIDAGHDPRRFATDLLERFRDLIVLQAVPDAAARGVVDASEDVLDRMREQA
VRIGPATLTRYAEVVHSGLGEMRGATAPRLLLEVVCARLLLPSATDAESALLQRVERIETRLNMSIPAARAAYPLQSAPA
EKAAQPSLPHQPFLASPDSQPAPDAQSSKLATPQAAAEPTPGMGAPNAAAVRTMWSTVREKVRQRSRTTEVMLAGATVRA
VEDNTLILTHGSAPLAKRLSEQHNVDVIAEALKDALGVNWRVRCEAGVPVPAVGALPACEGMVALPTQEKVPVLDVASAQ
QYEDEGMLAEPGRRDLSAPRPDLEEVALELLQNELGARRIDKWLTDAVED

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=304, Percent_Identity=24.6710526315789, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI31881687, Length=304, Percent_Identity=24.6710526315789, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1786676, Length=359, Percent_Identity=38.7186629526462, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1787341, Length=152, Percent_Identity=35.5263157894737, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17541988, Length=227, Percent_Identity=28.6343612334802, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65536; Mature: 65405

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLYRKYRPAAFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLN
CCCCHHCCCHHHHHHHHHHHCCCHHHHHEECCCCCEEEEECCCCCCCCCHHHHHHHHHCC
CAQGTTATPCGVCESCLSLAPNAPGHIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYR
CCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEE
VFIVDEAHMVTTAGFNALLKIVEEPPDHLIFIFATTEPEKVLPTIRSRTHHYPFRLLSPR
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEECCHH
TMRALVGRICAQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGEHVTYQRALKL
HHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
LGATDVGLIDDAVDALGAHDAAALFGAVESVIDAGHDPRRFATDLLERFRDLIVLQAVPD
HCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEHHCCCC
AAARGVVDASEDVLDRMREQAVRIGPATLTRYAEVVHSGLGEMRGATAPRLLLEVVCARL
HHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLPSATDAESALLQRVERIETRLNMSIPAARAAYPLQSAPAEKAAQPSLPHQPFLASPDS
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCC
QPAPDAQSSKLATPQAAAEPTPGMGAPNAAAVRTMWSTVREKVRQRSRTTEVMLAGATVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEE
AVEDNTLILTHGSAPLAKRLSEQHNVDVIAEALKDALGVNWRVRCEAGVPVPAVGALPAC
EECCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
EGMVALPTQEKVPVLDVASAQQYEDEGMLAEPGRRDLSAPRPDLEEVALELLQNELGARR
CCEEECCCCCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IDKWLTDAVED
HHHHHHHHHCC
>Mature Secondary Structure 
TLYRKYRPAAFAEVVGQEHVTEPLSIALEAGRINHAYLFSGPRGCGKTSSARILARSLN
CCCHHCCCHHHHHHHHHHHCCCHHHHHEECCCCCEEEEECCCCCCCCCHHHHHHHHHCC
CAQGTTATPCGVCESCLSLAPNAPGHIDVVELDAASHGGVDDTRELRDRAFYAPAQSRYR
CCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEE
VFIVDEAHMVTTAGFNALLKIVEEPPDHLIFIFATTEPEKVLPTIRSRTHHYPFRLLSPR
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEECCHH
TMRALVGRICAQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLVAGAEGEHVTYQRALKL
HHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
LGATDVGLIDDAVDALGAHDAAALFGAVESVIDAGHDPRRFATDLLERFRDLIVLQAVPD
HCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEHHCCCC
AAARGVVDASEDVLDRMREQAVRIGPATLTRYAEVVHSGLGEMRGATAPRLLLEVVCARL
HHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLPSATDAESALLQRVERIETRLNMSIPAARAAYPLQSAPAEKAAQPSLPHQPFLASPDS
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCC
QPAPDAQSSKLATPQAAAEPTPGMGAPNAAAVRTMWSTVREKVRQRSRTTEVMLAGATVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEE
AVEDNTLILTHGSAPLAKRLSEQHNVDVIAEALKDALGVNWRVRCEAGVPVPAVGALPAC
EECCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
EGMVALPTQEKVPVLDVASAQQYEDEGMLAEPGRRDLSAPRPDLEEVALELLQNELGARR
CCEEECCCCCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IDKWLTDAVED
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]