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The map label for this gene is crp [H]

Identifier: 221230711

GI number: 221230711

Start: 2726835

End: 2727509

Strand: Direct

Name: crp [H]

Synonym: MLBr_02302

Alternate gene names: 221230711

Gene position: 2726835-2727509 (Clockwise)

Preceding gene: 221230706

Following gene: 221230714

Centisome position: 83.44

GC content: 60.59

Gene sequence:

>675_bases
GTGGACGAGATCCTGGCAAGGGCAGGAATCTTCCAAGGGGTGGAACCCAGCGCCGTAGCTGCGCTGACCAAGCAACTCCA
ACCTGTCGACTTCCCCCGTGGCCATACAGTTTTCACTGAAGGCGAGCCAGGCGATCGGCTATACATCATCGTTTCGGGAA
AGGTCAAGATCGGTCGCCGCTCACCAGATGGCCGGGAGAATCTTCTCACGATCATGGGCCCGTCAGACATGTTCGGCGAG
TTGTCAATCTTCGACCCAGGACCACGGACGTCCAGCGCGACCACGATCACCGAAGTCCGAGCGGTATCAATGGACCGCGA
TGCTCTACGAGCATGGATCGCCGATCGTCCCGAAATCGCCGAACAGCTATTGCGGGTGCTAGCCCGGCGGCTGCGGCGGA
CCAACAACAATCTAGCTGACCTCATCTTCACTGACGTGCCTGGTCGGGTGGCTAAGCAACTGTTGCAGCTCGCCCAGCGT
TTCGGCACCCAGGAAGGTGGCGCGATGCGGGTCACCCACGACCTGACGCAAGAGGAGATCGCGCAATTGGTAGGCGCTTC
CCGAGAAACGGTGAACAAGGCGCTGGCCGATTTCGCGCACCGCGGCTGGATCCGTTTAGACGGTAAGAGCGTGCTGATCT
CGGACTCCGAACGCCTCGCCCGACGAGCGAGGTAA

Upstream 100 bases:

>100_bases
GAATCTGTTAGCCCTAGTCTCTAGGCTCGTCAGCGAAACAGAGGTAAACCGAGGTTAGCCTACCCATATGACATCGCAAG
AAAACTAATTAAGGGGCAAA

Downstream 100 bases:

>100_bases
GCGCCGTTAACATCGAAATCGACTTGCCGACAAGCTTTCTCGACATTTTTCCACGACAACATCAATCTCGGCGAGTGTTA
GCGGCGCAGATAATCCAATT

Product: putative Crp/Fnr-family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MDEILARAGIFQGVEPSAVAALTKQLQPVDFPRGHTVFTEGEPGDRLYIIVSGKVKIGRRSPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGAMRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLDGKSVLISDSERLARRAR

Sequences:

>Translated_224_residues
MDEILARAGIFQGVEPSAVAALTKQLQPVDFPRGHTVFTEGEPGDRLYIIVSGKVKIGRRSPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGAMRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLDGKSVLISDSERLARRAR
>Mature_224_residues
MDEILARAGIFQGVEPSAVAALTKQLQPVDFPRGHTVFTEGEPGDRLYIIVSGKVKIGRRSPDGRENLLTIMGPSDMFGE
LSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIAEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGAMRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLDGKSVLISDSERLARRAR

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI258613977, Length=140, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI258613975, Length=140, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI258613973, Length=140, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI258613971, Length=140, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI258613969, Length=140, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI38257139, Length=140, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1789756, Length=187, Percent_Identity=33.6898395721925, Blast_Score=100, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 24782; Mature: 24782

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEILARAGIFQGVEPSAVAALTKQLQPVDFPRGHTVFTEGEPGDRLYIIVSGKVKIGRR
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCEEECCC
SPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIA
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHH
EQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGAMRVTHDLTQEEI
HHHHHHHHHHHHHCCCCHHHHEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHH
AQLVGASRETVNKALADFAHRGWIRLDGKSVLISDSERLARRAR
HHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC
>Mature Secondary Structure
MDEILARAGIFQGVEPSAVAALTKQLQPVDFPRGHTVFTEGEPGDRLYIIVSGKVKIGRR
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCEEECCC
SPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRAWIADRPEIA
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHH
EQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGAMRVTHDLTQEEI
HHHHHHHHHHHHHCCCCHHHHEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHH
AQLVGASRETVNKALADFAHRGWIRLDGKSVLISDSERLARRAR
HHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]