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The map label for this gene is menC

Identifier: 221230690

GI number: 221230690

Start: 2691722

End: 2692726

Strand: Direct

Name: menC

Synonym: MLBr_02268

Alternate gene names: 221230690

Gene position: 2691722-2692726 (Clockwise)

Preceding gene: 221230681

Following gene: 221230691

Centisome position: 82.36

GC content: 66.67

Gene sequence:

>1005_bases
GTGATTCCCACCCTGACGGAGTTGTTGGACCGGCTACATGTAGTGGCTCTGCCGATGCGGGTGCGCTTCCGCGGCATCAC
CACCCGCGAAGTGGCGCTGATCGACGGCCCAGCAGGATGGGGAGAGTTCGGGGCCTTCCTCGAATACCAGCCCTTAGAGG
CGTCCGCGTGGCTGGTGGCGGGCATTGAGGCCGCTTACGGTGAGCCACCGGAGGGTCGCCGTGACCGGATCCCGATCAAC
GCCACCGTGCCAGCCGTGTCCGCCACCCAGGTACCCGAGGTGCTTGCCCGCTTTCCTGGCGTGCGCACCGCCAAGGTTAA
AGTGGCCGAGCCCGGACAAAACCTCGCCGACGATGTCGACCGGGTCAACGCGGTGCGGGAACTGGTGGAAACCGTGCGAG
TAGACGCTAATGGTGGCTGGAGCGTCGAGGCGGCGGCCCAGGCGGCCGTTGCCCTGACCGCCGACGGCCCGCTAGAGTAC
TTAGAACAACCGTGTGCCACAGTCGCCGAGCTCGCCGCGCTGCGCCGCCGGGTCGACATACCGATCGCTGCTGACGAAAG
CATCCGCAAGGCCGACGACCCGTTGGCGGTGGTCCGCTCGCACGCTGCCGACGTTGCAGTGCTGAAAGTCGCGCCGCTGG
GCGGGATTGCATCGTTCCTGGCTATCGCAGCGCAGATCGATATCCCGGTGGTGGTTTCCAGCGCGCTAGATTCGGTGGTC
GGGATCACCGCCGGACTGATCGCCGCCGCGGCCCTACCCGAACTCGACTACGCCTGCGGGCTGGGCACCGGCAGGCTGTT
CGTCGCAGACGTCGCCGAACCTATGCTGCCTGTCGATGGTTTCCTTCCGGTCGGACCGGTAACGCCTGACCCAGCGCGGC
TGCAGGCGCTGGGCACGCCGCCTGCCCGACGGCAGTGGTGGATCGACCGAGTCAAGACCTGCTACTCGCTGCTTGTACCG
TGTGCAGGTGATCAATCTGGCTTACGAAGACCGCGGGACCGGTGA

Upstream 100 bases:

>100_bases
TGATGGTGTTGTCAGCCGATCTGCGGACCGTGCCGCCCGAGCGGATCGCCGACTTCAAGGTGTGTGCGACGTTTCTGGCG
GGTCGCCGGGTGTACCCGCA

Downstream 100 bases:

>100_bases
ACCTGTTGTTTTCATCGCTGGCCGTGGCGGCGCAGGACGCACCTGGCAACCGCATCAAGTCCCGGCATTCTTGGCGGCCG
GCTATCGCGTCATCACCTTC

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MIPTLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVAGIEAAYGEPPEGRRDRIPIN
ATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVNAVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEY
LEQPCATVAELAALRRRVDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFLAIAAQIDIPVVVSSALDSVV
GITAGLIAAAALPELDYACGLGTGRLFVADVAEPMLPVDGFLPVGPVTPDPARLQALGTPPARRQWWIDRVKTCYSLLVP
CAGDQSGLRRPRDR

Sequences:

>Translated_334_residues
MIPTLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVAGIEAAYGEPPEGRRDRIPIN
ATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVNAVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEY
LEQPCATVAELAALRRRVDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFLAIAAQIDIPVVVSSALDSVV
GITAGLIAAAALPELDYACGLGTGRLFVADVAEPMLPVDGFLPVGPVTPDPARLQALGTPPARRQWWIDRVKTCYSLLVP
CAGDQSGLRRPRDR
>Mature_334_residues
MIPTLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVAGIEAAYGEPPEGRRDRIPIN
ATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVDRVNAVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEY
LEQPCATVAELAALRRRVDIPIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFLAIAAQIDIPVVVSSALDSVV
GITAGLIAAAALPELDYACGLGTGRLFVADVAEPMLPVDGFLPVGPVTPDPARLQALGTPPARRQWWIDRVKTCYSLLVP
CAGDQSGLRRPRDR

Specific function: Converts SHCHC to OSB

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENC_MYCLE (Q9CBB2)

Other databases:

- EMBL:   AL583925
- PIR:   H87192
- RefSeq:   NP_302476.1
- ProteinModelPortal:   Q9CBB2
- SMR:   Q9CBB2
- EnsemblBacteria:   EBMYCT00000028797
- GeneID:   908756
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2268
- NMPDR:   fig|272631.1.peg.1348
- Leproma:   ML2268
- GeneTree:   EBGT00050000017426
- HOGENOM:   HBG568083
- OMA:   LEYVEQP
- ProtClustDB:   PRK02901
- BioCyc:   MLEP272631:ML2268-MONOMER
- BRENDA:   4.2.1.113
- HAMAP:   MF_00470
- InterPro:   IPR013342
- InterPro:   IPR001354
- InterPro:   IPR010196
- PANTHER:   PTHR13794
- SMART:   SM00922

Pfam domain/function: PF01188 MR_MLE

EC number: =4.2.1.113

Molecular weight: Translated: 35311; Mature: 35311

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: ACT_SITE 107-107 ACT_SITE 209-209

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVA
CCCCHHHHHHHHHHHHHCCEEEEECCCEEEEEEEECCCCHHHHCCCEEECCCCCCHHHEE
GIEAAYGEPPEGRRDRIPINATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVD
CHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
RVNAVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEYLEQPCATVAELAALRRRVDI
HHHHHHHHHHHHEECCCCCCCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
PIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFLAIAAQIDIPVVVSSALDSVV
CCCCCCHHHHCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
GITAGLIAAAALPELDYACGLGTGRLFVADVAEPMLPVDGFLPVGPVTPDPARLQALGTP
HHHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCHHHEEECCCC
PARRQWWIDRVKTCYSLLVPCAGDQSGLRRPRDR
CHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure
MIPTLTELLDRLHVVALPMRVRFRGITTREVALIDGPAGWGEFGAFLEYQPLEASAWLVA
CCCCHHHHHHHHHHHHHCCEEEEECCCEEEEEEEECCCCHHHHCCCEEECCCCCCHHHEE
GIEAAYGEPPEGRRDRIPINATVPAVSATQVPEVLARFPGVRTAKVKVAEPGQNLADDVD
CHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
RVNAVRELVETVRVDANGGWSVEAAAQAAVALTADGPLEYLEQPCATVAELAALRRRVDI
HHHHHHHHHHHHEECCCCCCCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
PIAADESIRKADDPLAVVRSHAADVAVLKVAPLGGIASFLAIAAQIDIPVVVSSALDSVV
CCCCCCHHHHCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
GITAGLIAAAALPELDYACGLGTGRLFVADVAEPMLPVDGFLPVGPVTPDPARLQALGTP
HHHHHHHHHHHCCCCHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCHHHEEECCCC
PARRQWWIDRVKTCYSLLVPCAGDQSGLRRPRDR
CHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002