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The map label for this gene is pdc

Identifier: 221230638

GI number: 221230638

Start: 2575887

End: 2577596

Strand: Direct

Name: pdc

Synonym: MLBr_02167

Alternate gene names: 221230638

Gene position: 2575887-2577596 (Clockwise)

Preceding gene: 221230634

Following gene: 221230640

Centisome position: 78.82

GC content: 58.83

Gene sequence:

>1710_bases
GTGACCGCCCCCAAGATTGAAGCCGTCTATACCGTCGGCGCCTACCTGCTTGACCGCCTCGCTGAACTCGGTGTCACAGA
GATCTTCGGCGTACCCGGCGATTACACCCTGGAATTTCTCGACCATATCGTTGCCCATCCGACCATCAGATGGGTGGGCA
ACGCAAACGAACTGAACGCCGGATACGCTGCAGATGGGTATGGACGTTTACGCGGAATATCCGCTTTAGTGACGACATTC
GGAGTTGGCGAACTCTCGGCAGCCAACGCGATAGCGGGTAGCTACGCTGAGCATGTGCCCGTCGTTCACATTGTCGGCGC
CCCCCCTAAAGACGCGCAAAGCACCCACCGAGCGCTACACCACTCGCTAGGCGATGGGGACTTCGAGCACTTCATCCGGA
TTAGCAGCGAAATAACTTGCTCCCAAGCTAATCTCACAACAGCTACAGCATGCAAGGAGATTGATCGGGTACTCAGCGAA
GTGCGGAAGCACAAACGTCCCGGATACATACTACTGTCCACCGACGTAGCTCGCTTCCCTACCGAACCACCCGCCGCCCC
ATTGCCGGGCCATACCGACGGCACCAGCCCGCGTGCGCTGTCGCTGTTCATCGATGCCGCCACCAAACTCATTGCCGATA
AGCGGATGACGGTGCTGGCGGACTTGCTGGTCCATCGGTTGCAAGTGGTCAAAGAGCTCGAGACGTTGCTGACGGCCGAC
GTGGTGCCGTACGCCACGTTAATGTGGGGCAAAAGTCTGCTCGACGAGAGCTCACCTAACTTCCTGGGGATCTATGCCGG
GGCTGCTAGCACCGAAGCGGTCCGCGCGGCGATTGAGCAGGCACCTGTGCTGGTGACCGCCGGGGTGGTTTTTACCGACA
TGGTCAGTGGTTTCTTCAGCCAGCGGATCGACCCAGCCCGGACCATCGACGTCGGGCAGTACCAGAGCAGTGTGGCCGAT
AAGGTCTTCACTCCACTGGAAATGGGTGACGCGCTTGAGGCATTAGCGTCAATCCTGGTGCGCCGCGGTGTCAGCTCGCC
ACCAGTGGAATTACCTCCTGGCAACCCAACTGCGGACACACCATCACCCACTCAACGGCTGACCCAACAGATCTTGTGGG
ACAGGCTCTGTGCAGCGCTCACACCGGGAAACGTGGTACTAGCCGATCAGGGAACCGCGTTCTATGGCATGGTGGAACAC
CGGTTGCCGCGAGGAGTGACTTTCATCGGTCAACCCCTTTGGGGTTCAATCGGTTACACGCTGCCTGCAGCACTCGGTGC
GGGGTTAGCGCATCGCAACCGCAGGACGGTGTTGCTGCTCGGCGACGGCGCCGCGCAACTGACGATCCAGGAGCTCGGCT
CCTTCTACCGCGAGGGGTTGTCACCGGTCATTGTGGTAGTCAACAACGACGGCTATACAATCGAACGGGCGATACATGGA
GCAACAGCTCCCTACAATAACATTGCCAGATGGCGTTGGACCGACATCCCCGGTGCGCTGGGGGTAGCCAATCATTCGTC
CTTCCGTGCAGAAACCTACGGTGAGCTCGACGAGGCCTTCGCCGTCGCCGCCGAGCTTAAGGATCAGATGGTTTTCGTCG
AAGTCATCGTGCCTAAACTAGATCTTCCAAGCCTATTGACTGCATTGACCCGGCCAGCGCAGGACAGCAATCGGATTTTT
CAGTTGCCCAACCCAGGATGGGACAACTGA

Upstream 100 bases:

>100_bases
CGATTACGACGTCGCGGGATCCGTTGATTGCCGTGGCCCGCACGATAGCGAACCGGAGCCCGGCCTGGAGTAGTTCCTAC
CAAAGCGTACCGTCGTCTTC

Downstream 100 bases:

>100_bases
AACAGGCTTGGTTACATAGGTAGATAAACATCGAGTGATCCGCTTACTCTGCCGCCTCGATGCGAATCATGTCGAACAAC
CGAACAACGAACAGCGGGGA

Product: pyruvate (or indolepyruvate) decarboxylase

Products: aldehyde; CO2

Alternate protein names: KDC

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MTAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNAGYAADGYGRLRGISALVTTF
GVGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALHHSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSE
VRKHKRPGYILLSTDVARFPTEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTAD
VVPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFSQRIDPARTIDVGQYQSSVAD
KVFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADTPSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEH
RLPRGVTFIGQPLWGSIGYTLPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHG
ATAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKLDLPSLLTALTRPAQDSNRIF
QLPNPGWDN

Sequences:

>Translated_569_residues
MTAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNAGYAADGYGRLRGISALVTTF
GVGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALHHSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSE
VRKHKRPGYILLSTDVARFPTEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTAD
VVPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFSQRIDPARTIDVGQYQSSVAD
KVFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADTPSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEH
RLPRGVTFIGQPLWGSIGYTLPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHG
ATAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKLDLPSLLTALTRPAQDSNRIF
QLPNPGWDN
>Mature_568_residues
TAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNAGYAADGYGRLRGISALVTTFG
VGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALHHSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSEV
RKHKRPGYILLSTDVARFPTEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTADV
VPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFSQRIDPARTIDVGQYQSSVADK
VFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADTPSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEHR
LPRGVTFIGQPLWGSIGYTLPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHGA
TAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKLDLPSLLTALTRPAQDSNRIFQ
LPNPGWDN

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family

Homologues:

Organism=Escherichia coli, GI1790104, Length=481, Percent_Identity=22.2453222453222, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321524, Length=556, Percent_Identity=37.9496402877698, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6323073, Length=546, Percent_Identity=36.2637362637363, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6323163, Length=547, Percent_Identity=36.563071297989, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6320123, Length=555, Percent_Identity=31.3513513513514, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6320588, Length=610, Percent_Identity=31.3114754098361, Blast_Score=262, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDC_MYCLE (Q9CBD6)

Other databases:

- EMBL:   AL583924
- PIR:   B87180
- RefSeq:   NP_302424.1
- HSSP:   P06169
- ProteinModelPortal:   Q9CBD6
- SMR:   Q9CBD6
- EnsemblBacteria:   EBMYCT00000027971
- GeneID:   908871
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2167
- NMPDR:   fig|272631.1.peg.1296
- Leproma:   ML2167
- GeneTree:   EBGT00050000014643
- HOGENOM:   HBG479104
- OMA:   ADQGTAA
- ProtClustDB:   CLSK790786
- BioCyc:   MLEP272631:ML2167-MONOMER
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766
- PIRSF:   PIRSF036565

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N

EC number: 4.1.1.1

Molecular weight: Translated: 61146; Mature: 61015

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00187 TPP_ENZYMES

Important sites: BINDING 57-57

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
GYAADGYGRLRGISALVTTFGVGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALH
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
HSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSEVRKHKRPGYILLSTDVARFP
HHCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCC
TEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTAD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFS
HHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHH
QRIDPARTIDVGQYQSSVADKVFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADT
HCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEHRLPRGVTFIGQPLWGSIGYT
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHHCCCCCEEECCCCCCCCCHH
LPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHG
HHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHCC
ATAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKL
CCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
DLPSLLTALTRPAQDSNRIFQLPNPGWDN
CHHHHHHHHCCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure 
TAPKIEAVYTVGAYLLDRLAELGVTEIFGVPGDYTLEFLDHIVAHPTIRWVGNANELNA
CCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
GYAADGYGRLRGISALVTTFGVGELSAANAIAGSYAEHVPVVHIVGAPPKDAQSTHRALH
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
HSLGDGDFEHFIRISSEITCSQANLTTATACKEIDRVLSEVRKHKRPGYILLSTDVARFP
HHCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCC
TEPPAAPLPGHTDGTSPRALSLFIDAATKLIADKRMTVLADLLVHRLQVVKELETLLTAD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVPYATLMWGKSLLDESSPNFLGIYAGAASTEAVRAAIEQAPVLVTAGVVFTDMVSGFFS
HHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHH
QRIDPARTIDVGQYQSSVADKVFTPLEMGDALEALASILVRRGVSSPPVELPPGNPTADT
HCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PSPTQRLTQQILWDRLCAALTPGNVVLADQGTAFYGMVEHRLPRGVTFIGQPLWGSIGYT
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEHHHHHHHCCCCCEEECCCCCCCCCHH
LPAALGAGLAHRNRRTVLLLGDGAAQLTIQELGSFYREGLSPVIVVVNNDGYTIERAIHG
HHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHCC
ATAPYNNIARWRWTDIPGALGVANHSSFRAETYGELDEAFAVAAELKDQMVFVEVIVPKL
CCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
DLPSLLTALTRPAQDSNRIFQLPNPGWDN
CHHHHHHHHCCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-oxo acid

Specific reaction: A 2-oxo acid = an aldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002