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The map label for this gene is fbpB

Identifier: 221230573

GI number: 221230573

Start: 2418545

End: 2419528

Strand: Direct

Name: fbpB

Synonym: MLBr_02028

Alternate gene names: 221230573

Gene position: 2418545-2419528 (Clockwise)

Preceding gene: 221230570

Following gene: 221230574

Centisome position: 74.01

GC content: 59.86

Gene sequence:

>984_bases
ATGATTGACGTGAGCGGGAAGATCCGAGCCTGGGGGCGCTGGCTTTTGGTGGGTGCAGCTGCGACTCTGCCGAGCCTAAT
CAGCCTTGCTGGCGGAGCGGCGACCGCAAGCGCGTTCTCACGACCAGGCCTACCCGTCGAGTACCTACAGGTGCCGTCGG
AGGCGATGGGGCGCAGCATCAAGGTGCAGTTTCAAAACGGCGGAAACGGCTCTCCGGCGGTGTATCTGCTGGATGGTTTG
CGTGCGCAGGACGACTATAACGGCTGGGACATCAACACCTCCGCATTCGAGTGGTACTATCAGTCGGGACTCTCGGTCGT
GATGCCGGTCGGTGGGCAATCCAGCTTCTACAGCGACTGGTACAGCCCAGCGTGCGGCAAGGCAGGTTGCACGACCTACA
AGTGGGAAACATTCCTTACTAGCGAGCTGCCTAAATGGCTATCCGCCAATAGGAGTGTCAAATCCACCGGCAGCGCCGTG
GTCGGCCTCTCGATGGCCGGTTCCTCGGCCCTAATACTGGCAGCTTATCACCCCGATCAGTTCATCTATGCTGGCTCGTT
GTCGGCGCTGATGGACTCCTCCCAGGGGATAGAACCCCAGCTAATCGGCTTGGCGATGGGTGATGCTGGTGGCTACAAGG
CCGCGGACATGTGGGGACCACCAAATGACCCGGCCTGGCAACGAAACGACCCCATTCTGCAGGCTGGGAAGCTGGTCGCC
AACAACACCCACCTATGGGTTTACTGTGGTAACGGCACACCGTCAGAGTTGGGTGGAACCAACGTACCCGCGGAATTCCT
GGAGAACTTCGTGCACGGCAGCAACCTAAAGTTCCAGGACGCCTACAACGGTGCTGGTGGCCACAACGCTGTGTTCAACC
TCAATGCCGACGGAACGCACAGCTGGGAGTACTGGGGAGCCCAGCTCAACGCCATGAAGCCCGACCTACAGAACACCTTG
ATGGCTGTACCCCGCAGCGGTTAG

Upstream 100 bases:

>100_bases
CAGAACTGAGATCGCTTCGCGTCTCGATCGACATCTGGGCTATTCGCAGGGTAAATTCTGCCGAGAGCACCGACAACATA
CGATAAGGGGTATTAGGTTT

Downstream 100 bases:

>100_bases
CCTGGCCCTGTCTGTTGGTCCTTGCACCGATCGCCCGCCCAACTAGTCGCCCGGAATTTACCCGTGATATCAATCCATCC
GGTTGTGTTGTTGGCATGGC

Product: antigen 85A, mycolyltransferase

Products: NA

Alternate protein names: Antigen 85 complex B; 85B; Ag85B; Extracellular alpha-antigen; Fibronectin-binding protein B; Mycolyl transferase 85B

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSIKVQFQNGGNGSPAVYLLDGL
RAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDWYSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAV
VGLSMAGSSALILAAYHPDQFIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVA
NNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTHSWEYWGAQLNAMKPDLQNTL
MAVPRSG

Sequences:

>Translated_327_residues
MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSIKVQFQNGGNGSPAVYLLDGL
RAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDWYSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAV
VGLSMAGSSALILAAYHPDQFIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVA
NNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTHSWEYWGAQLNAMKPDLQNTL
MAVPRSG
>Mature_327_residues
MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSIKVQFQNGGNGSPAVYLLDGL
RAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDWYSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAV
VGLSMAGSSALILAAYHPDQFIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVA
NNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTHSWEYWGAQLNAMKPDLQNTL
MAVPRSG

Specific function: Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintain

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Secreted

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial A85 antigen family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): A85B_MYCLE (P31951)

Other databases:

- EMBL:   X60934
- EMBL:   AL049571
- EMBL:   AL583924
- PIR:   G87162
- PIR:   S20038
- PIR:   S34434
- RefSeq:   NP_302359.1
- ProteinModelPortal:   P31951
- SMR:   P31951
- EnsemblBacteria:   EBMYCT00000029413
- GeneID:   909036
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2028
- NMPDR:   fig|272631.1.peg.1231
- Leproma:   ML2028
- GeneTree:   EBGT00050000015316
- HOGENOM:   HBG564791
- OMA:   MSGSSAM
- BioCyc:   MLEP272631:ML2028-MONOMER
- InterPro:   IPR000801

Pfam domain/function: PF00756 Esterase

EC number: NA

Molecular weight: Translated: 34807; Mature: 34807

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: ACT_SITE 164-164 ACT_SITE 268-268 ACT_SITE 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSI
CCCCCCCHHHCCEEEEEEHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHCCCHHHCCCEE
KVQFQNGGNGSPAVYLLDGLRAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDW
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHCC
YSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAVVGLSMAGSSALILAAYHPDQ
CCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEECCCC
FIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVA
EEEECCHHHHHCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCCCCCHHHCCEEEE
NNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTH
CCCEEEEEECCCCCHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCC
SWEYWGAQLNAMKPDLQNTLMAVPRSG
CHHHHCCEEECCCCCHHHHHEECCCCC
>Mature Secondary Structure
MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSI
CCCCCCCHHHCCEEEEEEHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHCCCHHHCCCEE
KVQFQNGGNGSPAVYLLDGLRAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDW
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHCC
YSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAVVGLSMAGSSALILAAYHPDQ
CCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEECCCC
FIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVA
EEEECCHHHHHCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCCCCCHHHCCEEEE
NNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTH
CCCEEEEEECCCCCHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCC
SWEYWGAQLNAMKPDLQNTLMAVPRSG
CHHHHCCEEECCCCCHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1945858; 11234002