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The map label for this gene is xseA

Identifier: 221230522

GI number: 221230522

Start: 2326278

End: 2327564

Strand: Direct

Name: xseA

Synonym: MLBr_01940

Alternate gene names: 221230522

Gene position: 2326278-2327564 (Clockwise)

Preceding gene: 221230521

Following gene: 221230523

Centisome position: 71.18

GC content: 62.78

Gene sequence:

>1287_bases
GTGACGGAAGCGGTGCCGACTGACTCAGTCGACTCGAAAGCCAGTTCACAGGTAAATTCGGCCGAGAACCCGTTCCCAGT
TCGCGCGGTGGCGCTCCGGATCGCGGGATGGATCGACAAGCTGGGCACTGTTTGGGTAGAGGGACAATTGGCGCAAATCA
CCATGCGGCCCAACGCTAAGACCGTGTTCATGGTCTTACGTGACCCGGCTGCCGACATATCGCTGATTGTGACTTGCTCG
CGCGACTTTGTGCTACGCGCGCCGGTGAAACTAGCCGAAGGCATTCAGGTAGTGGTATGCGGCAAACCCTCATTCTACAT
CGGGCGCGGAACATTTTCTTTGCGCCTCAGCGATATTCGCGCAGTCGGCATCGGAGAGCTGCTAGTACGCATCGATCGGC
TACGCCGACTGTTGGACTCTGAGGGGCTCTTTGACCCACGGCTTAAACGGCCGATACCCTTCCTGCCCAACATGATCGGG
ATCATCACTGGCCGGGCCAGCGCTGCCGAACGCGATGTAACAACCGTGGCTAGCGCGCGCTGGCCTGCGGCGCGTTTCGC
TATCCGCAACACCGCTGTCCAGGGGCCCAACGCGGTGAGCCAGATTGTCGAGGCGTTGCGGGAACTTGATCGCAACGTTG
ATGTCGAGGTGATCGTGGTTGCCCGAGGTGGTGGCAGCGTCGAGGACCTGCTGACGTTTTCCGATGAAACGCTGTGCCGC
GCGATCGCAGCGTGCCGCACGCCGGTGATCAGCGCAGTCGGTCACGAACCCGACAACCCGCTATGCGATCTGGTCGCCGA
TCTGCGCGCCGCCACGCCCACCGACGCCGCCAAGAAAGTGGTCCCGGATGCCGCTGTCGAGCAGCGACTGATCGAGGACT
TGCAGCGGCGCAGCGCGCAGGCACTCCGCAATTGGGTATCCCGCGAGCAGCGGACGCTAGTCCAACTACGCAGTCGCCCA
GTGCTGGCTGAACCGCTGCGGACGCTGACGACGCGCTCCGAAGAAATTCACCGCGCCCAGTCGGCGATTCGCCGCGAGAT
CATTCGGCTGGTCACCACCGAGACCGAGCGGGTCGGTCATCTGGCCACGCAGCTAGCCACATTGGGCCCGGCAGCCACGT
TGGCGCGCGGCTATGCCATAGTGCAAGCCTTGGAAGACGGGACGCAAACCGTTACTGCGGCAGTGCTGCGGTCAGTCGAT
GATGCACCCACAGGCACCAGACTGCGGGTGCGGGTCTCTGACGGCGCCATAGTGGCAGTTAGTGAAGGACGGGCCGATGG
TCCCTGA

Upstream 100 bases:

>100_bases
TTGGCGAGCTCGAAGCCCTGCTGGTTTACGAGCAGGCCACCAAGGCTCGTGCTCCGTTCCAGACGCTGCTCGCCAACAGG
ATCACCAGCACGACTGCGAA

Downstream 100 bases:

>100_bases
AGACGATACCGCCGCGATGCGCTCCACTACTCCTATTAATACTACACCTATTAATCAACTTGGCTATGAAGCTTGCCGAG
ACGAGCTGATCGAAGTTGTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTEAVPTDSVDSKASSQVNSAENPFPVRAVALRIAGWIDKLGTVWVEGQLAQITMRPNAKTVFMVLRDPAADISLIVTCS
RDFVLRAPVKLAEGIQVVVCGKPSFYIGRGTFSLRLSDIRAVGIGELLVRIDRLRRLLDSEGLFDPRLKRPIPFLPNMIG
IITGRASAAERDVTTVASARWPAARFAIRNTAVQGPNAVSQIVEALRELDRNVDVEVIVVARGGGSVEDLLTFSDETLCR
AIAACRTPVISAVGHEPDNPLCDLVADLRAATPTDAAKKVVPDAAVEQRLIEDLQRRSAQALRNWVSREQRTLVQLRSRP
VLAEPLRTLTTRSEEIHRAQSAIRREIIRLVTTETERVGHLATQLATLGPAATLARGYAIVQALEDGTQTVTAAVLRSVD
DAPTGTRLRVRVSDGAIVAVSEGRADGP

Sequences:

>Translated_428_residues
MTEAVPTDSVDSKASSQVNSAENPFPVRAVALRIAGWIDKLGTVWVEGQLAQITMRPNAKTVFMVLRDPAADISLIVTCS
RDFVLRAPVKLAEGIQVVVCGKPSFYIGRGTFSLRLSDIRAVGIGELLVRIDRLRRLLDSEGLFDPRLKRPIPFLPNMIG
IITGRASAAERDVTTVASARWPAARFAIRNTAVQGPNAVSQIVEALRELDRNVDVEVIVVARGGGSVEDLLTFSDETLCR
AIAACRTPVISAVGHEPDNPLCDLVADLRAATPTDAAKKVVPDAAVEQRLIEDLQRRSAQALRNWVSREQRTLVQLRSRP
VLAEPLRTLTTRSEEIHRAQSAIRREIIRLVTTETERVGHLATQLATLGPAATLARGYAIVQALEDGTQTVTAAVLRSVD
DAPTGTRLRVRVSDGAIVAVSEGRADGP
>Mature_427_residues
TEAVPTDSVDSKASSQVNSAENPFPVRAVALRIAGWIDKLGTVWVEGQLAQITMRPNAKTVFMVLRDPAADISLIVTCSR
DFVLRAPVKLAEGIQVVVCGKPSFYIGRGTFSLRLSDIRAVGIGELLVRIDRLRRLLDSEGLFDPRLKRPIPFLPNMIGI
ITGRASAAERDVTTVASARWPAARFAIRNTAVQGPNAVSQIVEALRELDRNVDVEVIVVARGGGSVEDLLTFSDETLCRA
IAACRTPVISAVGHEPDNPLCDLVADLRAATPTDAAKKVVPDAAVEQRLIEDLQRRSAQALRNWVSREQRTLVQLRSRPV
LAEPLRTLTTRSEEIHRAQSAIRREIIRLVTTETERVGHLATQLATLGPAATLARGYAIVQALEDGTQTVTAAVLRSVDD
APTGTRLRVRVSDGAIVAVSEGRADGP

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=426, Percent_Identity=31.2206572769953, Blast_Score=185, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_MYCLE (Q9X783)

Other databases:

- EMBL:   AL049491
- EMBL:   AL583923
- PIR:   G87151
- RefSeq:   NP_302308.1
- EnsemblBacteria:   EBMYCT00000028662
- GeneID:   910082
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1940
- NMPDR:   fig|272631.1.peg.1180
- Leproma:   ML1940
- GeneTree:   EBGT00050000016801
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   MLEP272631:ML1940-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 46323; Mature: 46192

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVPTDSVDSKASSQVNSAENPFPVRAVALRIAGWIDKLGTVWVEGQLAQITMRPNAK
CCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCEEEEEEECCCCC
TVFMVLRDPAADISLIVTCSRDFVLRAPVKLAEGIQVVVCGKPSFYIGRGTFSLRLSDIR
EEEEEEECCCCCEEEEEEECCCEEEECCHHHHCCCEEEEECCCCEEEECCEEEEEECCHH
AVGIGELLVRIDRLRRLLDSEGLFDPRLKRPIPFLPNMIGIITGRASAAERDVTTVASAR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC
WPAARFAIRNTAVQGPNAVSQIVEALRELDRNVDVEVIVVARGGGSVEDLLTFSDETLCR
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCHHHHHH
AIAACRTPVISAVGHEPDNPLCDLVADLRAATPTDAAKKVVPDAAVEQRLIEDLQRRSAQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHH
ALRNWVSREQRTLVQLRSRPVLAEPLRTLTTRSEEIHRAQSAIRREIIRLVTTETERVGH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LATQLATLGPAATLARGYAIVQALEDGTQTVTAAVLRSVDDAPTGTRLRVRVSDGAIVAV
HHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEE
SEGRADGP
ECCCCCCC
>Mature Secondary Structure 
TEAVPTDSVDSKASSQVNSAENPFPVRAVALRIAGWIDKLGTVWVEGQLAQITMRPNAK
CCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCEEEEEEECCCCC
TVFMVLRDPAADISLIVTCSRDFVLRAPVKLAEGIQVVVCGKPSFYIGRGTFSLRLSDIR
EEEEEEECCCCCEEEEEEECCCEEEECCHHHHCCCEEEEECCCCEEEECCEEEEEECCHH
AVGIGELLVRIDRLRRLLDSEGLFDPRLKRPIPFLPNMIGIITGRASAAERDVTTVASAR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC
WPAARFAIRNTAVQGPNAVSQIVEALRELDRNVDVEVIVVARGGGSVEDLLTFSDETLCR
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCHHHHHH
AIAACRTPVISAVGHEPDNPLCDLVADLRAATPTDAAKKVVPDAAVEQRLIEDLQRRSAQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHH
ALRNWVSREQRTLVQLRSRPVLAEPLRTLTTRSEEIHRAQSAIRREIIRLVTTETERVGH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LATQLATLGPAATLARGYAIVQALEDGTQTVTAAVLRSVDDAPTGTRLRVRVSDGAIVAV
HHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEE
SEGRADGP
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002