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The map label for this gene is ubiB [C]

Identifier: 221230491

GI number: 221230491

Start: 2282213

End: 2283559

Strand: Direct

Name: ubiB [C]

Synonym: MLBr_01898

Alternate gene names: 221230491

Gene position: 2282213-2283559 (Clockwise)

Preceding gene: 221230454

Following gene: 221230492

Centisome position: 69.83

GC content: 59.69

Gene sequence:

>1347_bases
ATGAGTTCCACCAATAACCACCAGGTGGTCAAGCTAGACCGAGTGCCCTTACCTGTCGAAGCGGCCCGGATAGCAGCCAC
ATATTGGCAAATCACCCGCGCTGCCGCTCGCGTCGCAACCAAGCTGGCGGGCAAGGGTCCGTGGCAGCAAAAGGTGATCA
GGGAAATCCCGCAGACCTTTGCTAACCTAGGGCCGACGTACGTTAAGTTCGGACAGATCATAGCGTCCAGCCCCAGCGCA
TTTGGTGAGTCGCTGGCGCGCGAATTCCGTGGCCTGCTCGACCAAGTGCCACCAGCCGACACGAACGAGGTGCACAAGCT
GTTCGTCGAGGAGCTTGGCGACGCGCCTTCCAAACTGTTCGCCAGCTTCTCCGAAGAGCCGTTCGCGTCGGCGTCCATCG
CTCAGGTACATTCCGCGATCCTGCACAGCGGCGAGCACGTCGTCGTAAAGATCCAGCGACCCGGCATCCGACGCCGAGTC
GCCGCCGACCTGCAAATCCTGAAGCGCTTCGCGCAAGCAGTCGAACTAGCCAAGCTGGGCCGTCGGCTCTCGGCGCAAGA
CGTCGTAGCGGATTTTTCCGACAACCTTGCCGAAGAGCTGAATTTCCGTCTCGAGGCACAGTCGATGGAAGCGTGGGGCT
CATACCTGCACACCTCGCCGCTAGGCAAGAACATCCGCGTACCGAAGGTGCACTGGGAATTCACGGGCGAACGGGTGTTG
ACGATGGAGCAGGTACATGGCATCCGCATAGACAATGCGGATGCCATCCGCAAGTCTGGCTTCGACGGCGTCGAGCTGGT
CAAGGCGCTATTGTTCTCGGTGTTTGAGGGCGGTCTGCGACACGGCCTGTTCCATGGCGACCTGCACGCGGGCAACCTGC
ATGTTGACGACCAAGGTCGCATCGTGTTCTTCGACTTCGGGATCATGGGCCGCATCGATCCGCGCACCCGGTGGTTACTA
CGCGAACTGGTATTTGCCCTGCTGGTGAAAAAGGACCACGCTGCTGCTGGCAAAATCGTCGTGTTGATGGGCGCCGTGGG
CACCGTGAAACCCGAGGCTCGGGCTGCCAAAGACCTGGAAAACTTCACCACGCCTCTGGCCATGAAAACCCTCGGCGACA
TGTCCTACACCGATATCGGCCGGCAGCTGTCGGCGCTGTCCGACGCCTACAACGTTAAGTTGCCCCGCGAACTGGTGCTG
ATCGGCAAGCAATTCCTCTACGTCGAGCGGTACATGAAGCTGCTGGCGCCGGAATGGCAGATAATGTTGGATCCGGAGCT
GACAGGGTACTTCGCAAACTTTATGGTCGAAGTCAGCCGTGAGCATCAATCCGATGTGGAGATCTAG

Upstream 100 bases:

>100_bases
TGTTCTAGGAAATCATCGTAATTTAGAGTAGGTAGTCAGTGACGCCCTGGCGTCACACTGAATTGGGACCCAACACCACC
AGTTTGGCACACTACACAGA

Downstream 100 bases:

>100_bases
TGGAAGTCCGTAGCGGTTACGCCACCTCGGGCGACTTGAAGCTGTACTACGAGGACATGGGCAACGTCGATGACCCGCCG
GTACTGCTGATCATGGGGCT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSSTNNHQVVKLDRVPLPVEAARIAATYWQITRAAARVATKLAGKGPWQQKVIREIPQTFANLGPTYVKFGQIIASSPSA
FGESLAREFRGLLDQVPPADTNEVHKLFVEELGDAPSKLFASFSEEPFASASIAQVHSAILHSGEHVVVKIQRPGIRRRV
AADLQILKRFAQAVELAKLGRRLSAQDVVADFSDNLAEELNFRLEAQSMEAWGSYLHTSPLGKNIRVPKVHWEFTGERVL
TMEQVHGIRIDNADAIRKSGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLHVDDQGRIVFFDFGIMGRIDPRTRWLL
RELVFALLVKKDHAAAGKIVVLMGAVGTVKPEARAAKDLENFTTPLAMKTLGDMSYTDIGRQLSALSDAYNVKLPRELVL
IGKQFLYVERYMKLLAPEWQIMLDPELTGYFANFMVEVSREHQSDVEI

Sequences:

>Translated_448_residues
MSSTNNHQVVKLDRVPLPVEAARIAATYWQITRAAARVATKLAGKGPWQQKVIREIPQTFANLGPTYVKFGQIIASSPSA
FGESLAREFRGLLDQVPPADTNEVHKLFVEELGDAPSKLFASFSEEPFASASIAQVHSAILHSGEHVVVKIQRPGIRRRV
AADLQILKRFAQAVELAKLGRRLSAQDVVADFSDNLAEELNFRLEAQSMEAWGSYLHTSPLGKNIRVPKVHWEFTGERVL
TMEQVHGIRIDNADAIRKSGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLHVDDQGRIVFFDFGIMGRIDPRTRWLL
RELVFALLVKKDHAAAGKIVVLMGAVGTVKPEARAAKDLENFTTPLAMKTLGDMSYTDIGRQLSALSDAYNVKLPRELVL
IGKQFLYVERYMKLLAPEWQIMLDPELTGYFANFMVEVSREHQSDVEI
>Mature_447_residues
SSTNNHQVVKLDRVPLPVEAARIAATYWQITRAAARVATKLAGKGPWQQKVIREIPQTFANLGPTYVKFGQIIASSPSAF
GESLAREFRGLLDQVPPADTNEVHKLFVEELGDAPSKLFASFSEEPFASASIAQVHSAILHSGEHVVVKIQRPGIRRRVA
ADLQILKRFAQAVELAKLGRRLSAQDVVADFSDNLAEELNFRLEAQSMEAWGSYLHTSPLGKNIRVPKVHWEFTGERVLT
MEQVHGIRIDNADAIRKSGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLHVDDQGRIVFFDFGIMGRIDPRTRWLLR
ELVFALLVKKDHAAAGKIVVLMGAVGTVKPEARAAKDLENFTTPLAMKTLGDMSYTDIGRQLSALSDAYNVKLPRELVLI
GKQFLYVERYMKLLAPEWQIMLDPELTGYFANFMVEVSREHQSDVEI

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=322, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI40254938, Length=255, Percent_Identity=30.1960784313725, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI217035081, Length=195, Percent_Identity=31.7948717948718, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI27363457, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI217416386, Length=205, Percent_Identity=31.219512195122, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI34147522, Length=277, Percent_Identity=25.2707581227437, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367309, Length=366, Percent_Identity=29.2349726775956, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17559152, Length=287, Percent_Identity=29.616724738676, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=232, Percent_Identity=27.1551724137931, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=299, Percent_Identity=29.4314381270903, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=228, Percent_Identity=28.5087719298246, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325148, Length=254, Percent_Identity=24.8031496062992, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24662575, Length=334, Percent_Identity=29.0419161676647, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI22024280, Length=266, Percent_Identity=27.0676691729323, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859849, Length=262, Percent_Identity=27.4809160305344, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49914; Mature: 49783

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTNNHQVVKLDRVPLPVEAARIAATYWQITRAAARVATKLAGKGPWQQKVIREIPQTF
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ANLGPTYVKFGQIIASSPSAFGESLAREFRGLLDQVPPADTNEVHKLFVEELGDAPSKLF
HHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHH
ASFSEEPFASASIAQVHSAILHSGEHVVVKIQRPGIRRRVAADLQILKRFAQAVELAKLG
HHCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRLSAQDVVADFSDNLAEELNFRLEAQSMEAWGSYLHTSPLGKNIRVPKVHWEFTGERVL
HHCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEE
TMEQVHGIRIDNADAIRKSGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLHVDDQGR
EHHHHCCEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEECCEECCCEEECCCCC
IVFFDFGIMGRIDPRTRWLLRELVFALLVKKDHAAAGKIVVLMGAVGTVKPEARAAKDLE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
NFTTPLAMKTLGDMSYTDIGRQLSALSDAYNVKLPRELVLIGKQFLYVERYMKLLAPEWQ
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
IMLDPELTGYFANFMVEVSREHQSDVEI
EEECCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSTNNHQVVKLDRVPLPVEAARIAATYWQITRAAARVATKLAGKGPWQQKVIREIPQTF
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ANLGPTYVKFGQIIASSPSAFGESLAREFRGLLDQVPPADTNEVHKLFVEELGDAPSKLF
HHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHH
ASFSEEPFASASIAQVHSAILHSGEHVVVKIQRPGIRRRVAADLQILKRFAQAVELAKLG
HHCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRLSAQDVVADFSDNLAEELNFRLEAQSMEAWGSYLHTSPLGKNIRVPKVHWEFTGERVL
HHCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEE
TMEQVHGIRIDNADAIRKSGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLHVDDQGR
EHHHHCCEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEECCEECCCEEECCCCC
IVFFDFGIMGRIDPRTRWLLRELVFALLVKKDHAAAGKIVVLMGAVGTVKPEARAAKDLE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
NFTTPLAMKTLGDMSYTDIGRQLSALSDAYNVKLPRELVLIGKQFLYVERYMKLLAPEWQ
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
IMLDPELTGYFANFMVEVSREHQSDVEI
EEECCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]