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The map label for this gene is hsp18

Identifier: 221230432

GI number: 221230432

Start: 2174224

End: 2174670

Strand: Direct

Name: hsp18

Synonym: MLBr_01795

Alternate gene names: 221230432

Gene position: 2174224-2174670 (Clockwise)

Preceding gene: 221230431

Following gene: 221230433

Centisome position: 66.53

GC content: 56.6

Gene sequence:

>447_bases
ATGCTGATGCGTACTGACCCGTTCCGTGAACTGGACCGCTTCGCCGAGCAAGTGTTAGGTACGTCTGCCCGCCCAGCAGT
AATGCCCATGGACGCTTGGCGTGAGGGCGAAGAATTCGTCGTCGAGTTCGACCTTCCTGGCATCAAAGCCGATTCACTGG
ACATTGACATCGAACGCAACGTAGTCACCGTGCGGGCCGAGCGCCCAGGCGTCGACCCCGATCGGGAAATGCTTGCTGCC
GAGCGGCCACGCGGTGTGTTCAATCGTCAGCTGGTTCTCGGCGAAAACCTCGACACCGAACGGATCTTGGCTTCCTACCA
AGAAGGTGTCCTGAAGTTGTCGATACCAGTAGCCGAAAGGGCTAAACCGCGCAAGATCTCCGTTGATCGTGGCAACAACG
GACACCAGACCATAAACAAAACCGCACACGAAATCATAGATGCCTAA

Upstream 100 bases:

>100_bases
GCATCAATATATCGACCAGTGCTATATCAAATCTATGTAGTCAGGAACAGCTATATAGTTATAGTTTGTCACAACAGATT
GGAGTGCGAGGTGACCACAC

Downstream 100 bases:

>100_bases
TCGACTGTTGTTTGCGCAACAAGCTAAGCACGAAGCTAAGCACGCCGCTGCGGTCAAAAGCCCGTCTTAGCCATGGATCT
TTAAAGTATCCGAACATTTC

Product: 18 KDA antigen (HSP 16.7)

Products: NA

Alternate protein names: HSP 16.7

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MLMRTDPFRELDRFAEQVLGTSARPAVMPMDAWREGEEFVVEFDLPGIKADSLDIDIERNVVTVRAERPGVDPDREMLAA
ERPRGVFNRQLVLGENLDTERILASYQEGVLKLSIPVAERAKPRKISVDRGNNGHQTINKTAHEIIDA

Sequences:

>Translated_148_residues
MLMRTDPFRELDRFAEQVLGTSARPAVMPMDAWREGEEFVVEFDLPGIKADSLDIDIERNVVTVRAERPGVDPDREMLAA
ERPRGVFNRQLVLGENLDTERILASYQEGVLKLSIPVAERAKPRKISVDRGNNGHQTINKTAHEIIDA
>Mature_148_residues
MLMRTDPFRELDRFAEQVLGTSARPAVMPMDAWREGEEFVVEFDLPGIKADSLDIDIERNVVTVRAERPGVDPDREMLAA
ERPRGVFNRQLVLGENLDTERILASYQEGVLKLSIPVAERAKPRKISVDRGNNGHQTINKTAHEIIDA

Specific function: Not known. This protein is one of the major immune reactive proteins in mycobacteria

COG id: COG0071

COG function: function code O; Molecular chaperone (small heat shock protein)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small heat shock protein (HSP20) family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 18KD_MYCLE (P12809)

Other databases:

- EMBL:   M22587
- EMBL:   M19058
- EMBL:   AL583923
- PIR:   A27586
- RefSeq:   NP_302218.1
- ProteinModelPortal:   P12809
- SMR:   P12809
- EnsemblBacteria:   EBMYCT00000029492
- GeneID:   910696
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1795
- NMPDR:   fig|272631.1.peg.1090
- Leproma:   ML1795
- GeneTree:   EBGT00050000016059
- HOGENOM:   HBG748242
- OMA:   FVVAFDL
- ProtClustDB:   CLSK557022
- BioCyc:   MLEP272631:ML1795-MONOMER
- InterPro:   IPR002068
- InterPro:   IPR008978

Pfam domain/function: PF00011 HSP20; SSF49764 HSP20_chap

EC number: NA

Molecular weight: Translated: 16707; Mature: 16707

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS01031 HSP20

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMRTDPFRELDRFAEQVLGTSARPAVMPMDAWREGEEFVVEFDLPGIKADSLDIDIERN
CCCCCCCHHHHHHHHHHHHCCCCCCCEECHHHCCCCCEEEEEECCCCCCCCCEEEEECCC
VVTVRAERPGVDPDREMLAAERPRGVFNRQLVLGENLDTERILASYQEGVLKLSIPVAER
EEEEEECCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCEEEEECCHHHC
AKPRKISVDRGNNGHQTINKTAHEIIDA
CCCCEEEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLMRTDPFRELDRFAEQVLGTSARPAVMPMDAWREGEEFVVEFDLPGIKADSLDIDIERN
CCCCCCCHHHHHHHHHHHHCCCCCCCEECHHHCCCCCEEEEEECCCCCCCCCEEEEECCC
VVTVRAERPGVDPDREMLAAERPRGVFNRQLVLGENLDTERILASYQEGVLKLSIPVAER
EEEEEECCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHCCEEEEECCHHHC
AKPRKISVDRGNNGHQTINKTAHEIIDA
CCCCEEEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3056923; 2447183; 11234002