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The map label for this gene is malY [C]

Identifier: 221230431

GI number: 221230431

Start: 2171439

End: 2172647

Strand: Direct

Name: malY [C]

Synonym: MLBr_01794

Alternate gene names: 221230431

Gene position: 2171439-2172647 (Clockwise)

Preceding gene: 221230430

Following gene: 221230432

Centisome position: 66.44

GC content: 60.05

Gene sequence:

>1209_bases
GTGACTTCTAATCCGCTCGAACAACTAACGATAGAACAACTGCAATGCCGCACCAGTATGAAGTGGCGCGCACATCCCGA
AGACGTGTTGCCATTGTGGGTCGCGGAAATGGATGTGCTGCTAGCGCCGACGGTGGCCGAAGCCGTCCATCGTGCTGTCG
ACAACGGTGATACCGGTTATCCTTACGGAACCACGTTCGCCGAGGCGATAAGTGAATTCGCTTCGCAGCGTTGGCAATGG
CACGACCTAGACGTCAGCCGCACAGCAATCGTTCCCGACGTCATGCTTGGTGTCGTTGAGATGCTACGCCTGATCACTGA
TCGGGGTGACGGCGTCATAGTCAGCCCGCCAGTATACCCCCCGTTCTACGCCTTCGTGACACACGATGGCCGTCGGGTGC
TCGAAGCACCGCTCGGCCGCGACGGCCGGCTTGACTTGGCCGCGTTGCAGGACGCGTTTTCGCGTGCCCGACGTTCGAGC
GGACCCAACGGAAAAGTCGCATACCTGTTATGTAATCCGCACAATCCGACCGGATCGGTGCACACCGTCGCCGAATTGCA
CGGGGTTGCCGAACTCGCCCGTCGGTTCGGTGTTCGGGTGATATCAGACGAAATTCACGCTCCGCTCGTCTTGTCCGGTG
CGCGATTCACCCCATATCTGAGTATCCCCGGAGCAGAAAACGCGTTCGCCCTGATGTCAGCCACCAAGGGGTGGAACCTG
TGCGGGTTGAAAGCGGCCATTGCCATCGCCGGTCGTGAAGCGGCCGCCGACCTTCGCCGGATACCAAAAGAGGTCAGCCA
CGGCCCCAGCCATCTGGGCATCATCGCGCATACCGCAGCCTTCCGCACCGGCAGCAGCTGGCTCGACGCGTTGTTGCAAG
GTCTGGAAGCGAACCGCGCGTTGCTCAGAGATCTGGTCACCAAGCATTTACCCGGAGTGAGATATCAACGACCGCAGGGC
ACGTATCTGACTTGGCTGGATTGCCGACACCTCGGTTTCGACGAGCAGATCAACGAAGGGCTTGCGGCAATCTCCGATCT
ATCCGGACCAGCCCGCTGGTTCCTCGACCACTCGCGTGTGGCCCTCACTTCCGGCCACGCCTTCGGAACAGGCGGAGTCG
GACACGTACGCGTGAACTTCGCGACCTCCCAAGCAATCCTCATCGAGGCCCTATCGCGAATGGGTCGAGCACTCGTCAAT
TTCCGATAA

Upstream 100 bases:

>100_bases
TTGTCCAAATCATCACTGCAATCGAGGTCAGTGGACCGCAGACAGGGAGTCTAACGCCGGCCGGGACAACAATGGTTGCC
GATTCGTCTAATCTGCCTGA

Downstream 100 bases:

>100_bases
TCGTCCGGTAGCGCGCTGCAAACCACGGCATCAGTGTTACGCAGCCTCGGCTAGCATGCGTGGTAAAATCACAGTACGAA
CGGCTTCGACCCTTTGAAGC

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDTGYPYGTTFAEAISEFASQRWQW
HDLDVSRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPLGRDGRLDLAALQDAFSRARRSS
GPNGKVAYLLCNPHNPTGSVHTVAELHGVAELARRFGVRVISDEIHAPLVLSGARFTPYLSIPGAENAFALMSATKGWNL
CGLKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFRTGSSWLDALLQGLEANRALLRDLVTKHLPGVRYQRPQG
TYLTWLDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRVALTSGHAFGTGGVGHVRVNFATSQAILIEALSRMGRALVN
FR

Sequences:

>Translated_402_residues
MTSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDTGYPYGTTFAEAISEFASQRWQW
HDLDVSRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPLGRDGRLDLAALQDAFSRARRSS
GPNGKVAYLLCNPHNPTGSVHTVAELHGVAELARRFGVRVISDEIHAPLVLSGARFTPYLSIPGAENAFALMSATKGWNL
CGLKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFRTGSSWLDALLQGLEANRALLRDLVTKHLPGVRYQRPQG
TYLTWLDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRVALTSGHAFGTGGVGHVRVNFATSQAILIEALSRMGRALVN
FR
>Mature_401_residues
TSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDTGYPYGTTFAEAISEFASQRWQWH
DLDVSRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPLGRDGRLDLAALQDAFSRARRSSG
PNGKVAYLLCNPHNPTGSVHTVAELHGVAELARRFGVRVISDEIHAPLVLSGARFTPYLSIPGAENAFALMSATKGWNLC
GLKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFRTGSSWLDALLQGLEANRALLRDLVTKHLPGVRYQRPQGT
YLTWLDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRVALTSGHAFGTGGVGHVRVNFATSQAILIEALSRMGRALVNF
R

Specific function: Acts As A Beta-Cystathionase And As A Repressor Of The Maltose Regulon. [C]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily

Homologues:

Organism=Escherichia coli, GI1787909, Length=383, Percent_Identity=30.2872062663185, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788722, Length=395, Percent_Identity=24.3037974683544, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBL_MYCLE (Q9CBM9)

Other databases:

- EMBL:   AL583923
- PIR:   C87133
- RefSeq:   NP_302217.1
- ProteinModelPortal:   Q9CBM9
- SMR:   Q9CBM9
- EnsemblBacteria:   EBMYCT00000028483
- GeneID:   910697
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1794
- NMPDR:   fig|272631.1.peg.1089
- Leproma:   ML1794
- GeneTree:   EBGT00070000032189
- HOGENOM:   HBG681988
- OMA:   WNLAGLK
- ProtClustDB:   CLSK872043
- BioCyc:   MLEP272631:ML1794-MONOMER
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.4.1.8

Molecular weight: Translated: 43862; Mature: 43730

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDTGY
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
PYGTTFAEAISEFASQRWQWHDLDVSRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYP
CCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
PFYAFVTHDGRRVLEAPLGRDGRLDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSV
CEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCH
HTVAELHGVAELARRFGVRVISDEIHAPLVLSGARFTPYLSIPGAENAFALMSATKGWNL
HHHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCCCCCEEECCCCCCCEEEEECCCCCCC
CGLKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFRTGSSWLDALLQGLEANRA
HHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHH
LLRDLVTKHLPGVRYQRPQGTYLTWLDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRV
HHHHHHHHHCCCCCEECCCCCEEEEECHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCEE
ALTSGHAFGTGGVGHVRVNFATSQAILIEALSRMGRALVNFR
EEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDTGY
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
PYGTTFAEAISEFASQRWQWHDLDVSRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYP
CCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
PFYAFVTHDGRRVLEAPLGRDGRLDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSV
CEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCH
HTVAELHGVAELARRFGVRVISDEIHAPLVLSGARFTPYLSIPGAENAFALMSATKGWNL
HHHHHHHHHHHHHHHHCCEEECCCCCCCEEEECCCCCCEEECCCCCCCEEEEECCCCCCC
CGLKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFRTGSSWLDALLQGLEANRA
HHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHHH
LLRDLVTKHLPGVRYQRPQGTYLTWLDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRV
HHHHHHHHHCCCCCEECCCCCEEEEECHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCEE
ALTSGHAFGTGGVGHVRVNFATSQAILIEALSRMGRALVNFR
EEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002