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The map label for this gene is rnc

Identifier: 221230354

GI number: 221230354

Start: 2000821

End: 2001537

Strand: Reverse

Name: rnc

Synonym: MLBr_01659

Alternate gene names: 221230354

Gene position: 2001537-2000821 (Counterclockwise)

Preceding gene: 221230355

Following gene: 221230353

Centisome position: 61.25

GC content: 59.14

Gene sequence:

>717_bases
GTGACCCAGCCTCGACAAGCTTTGCTCGATGCGTTCGGCGTCGATCTGCCTGATGAGCTACTTTCGCTGGCGTTGACACA
CCGCAGTTATGCCTACGAGCACGGCGGGTTACCAACCAACGAGCGCCTGGAGTTTCTTGGTGACGCTGTCCTGAGCTTGA
CCATTACCGATGAGTTGTTCCATCGCCACCCCGACCGTTCGGAAGGGGATCTGGCTAAATTGCGTGCCAGTGTGGTCAAC
ACCCAGGCACTGGCTTACGTTGCGCGAAACTTATCCGATGGTGGTCTCGGTGTCTACCTGCTGCTGGGCCGTGGCGAGAC
AAACACCGGAGGAGCGGATAAGTCCAGCATACTGGCCGACGGCATGGAATCGCTGCTGGGTGCGATCTACCTGCATCACG
GTATTGAGGTGGCCCGTCAGGTGATCTTGCGGTTGTTTGGTACGCTGCTGGACGCTGCGCCTACGCTGGGAGCTGGGTTG
GATTGGAAGACCAGCTTGCAGGAGCTAACAGCGGCACGCGGCATGGGCGTGCCATCGTACGTGGTGACCTCCACCGGTCC
GGACCACGACAAAGAATTCACCGCGGTTGTCGTCGTGATGGACACCGAATACGGGTCAGGTATTGGCCACTCGAAGAAAG
AGGCTGAGCAGAAAGCCGCATCAGCGGCTTGGAAAGCACTCGATGTGCTGGGCGGCGTCGGGAAAACGTCCGTGTAG

Upstream 100 bases:

>100_bases
ATCCCCATGACCGCATCGACCCGTGGTGGGCCAAGTTGACTGACATGTTGGCGCCTGACGTCCCGCAGACATCGGAAACG
GATGGATCACGGAGTGAGTG

Downstream 100 bases:

>100_bases
TCGATGGTTATGATTCGCTGCGCCCGGTTTCGCCGGGCTTGGGATCATAACTAAATGCCTGAACTGCCCGAAGTAGAGGT
GGTGCGGCGCGGCCTGCAGG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTQPRQALLDAFGVDLPDELLSLALTHRSYAYEHGGLPTNERLEFLGDAVLSLTITDELFHRHPDRSEGDLAKLRASVVN
TQALAYVARNLSDGGLGVYLLLGRGETNTGGADKSSILADGMESLLGAIYLHHGIEVARQVILRLFGTLLDAAPTLGAGL
DWKTSLQELTAARGMGVPSYVVTSTGPDHDKEFTAVVVVMDTEYGSGIGHSKKEAEQKAASAAWKALDVLGGVGKTSV

Sequences:

>Translated_238_residues
MTQPRQALLDAFGVDLPDELLSLALTHRSYAYEHGGLPTNERLEFLGDAVLSLTITDELFHRHPDRSEGDLAKLRASVVN
TQALAYVARNLSDGGLGVYLLLGRGETNTGGADKSSILADGMESLLGAIYLHHGIEVARQVILRLFGTLLDAAPTLGAGL
DWKTSLQELTAARGMGVPSYVVTSTGPDHDKEFTAVVVVMDTEYGSGIGHSKKEAEQKAASAAWKALDVLGGVGKTSV
>Mature_237_residues
TQPRQALLDAFGVDLPDELLSLALTHRSYAYEHGGLPTNERLEFLGDAVLSLTITDELFHRHPDRSEGDLAKLRASVVNT
QALAYVARNLSDGGLGVYLLLGRGETNTGGADKSSILADGMESLLGAIYLHHGIEVARQVILRLFGTLLDAAPTLGAGLD
WKTSLQELTAARGMGVPSYVVTSTGPDHDKEFTAVVVVMDTEYGSGIGHSKKEAEQKAASAAWKALDVLGGVGKTSV

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=213, Percent_Identity=31.924882629108, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI155030234, Length=213, Percent_Identity=31.924882629108, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788920, Length=214, Percent_Identity=42.0560747663551, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=28.6324786324786, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=28.6324786324786, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137682, Length=226, Percent_Identity=31.4159292035398, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_MYCLE (O69469)

Other databases:

- EMBL:   AL023635
- EMBL:   AL583923
- PIR:   T44706
- RefSeq:   NP_302140.1
- ProteinModelPortal:   O69469
- SMR:   O69469
- EnsemblBacteria:   EBMYCT00000029261
- GeneID:   910019
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1659
- NMPDR:   fig|272631.1.peg.1012
- Leproma:   ML1659
- GeneTree:   EBGT00050000017732
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   MLEP272631:ML1659-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25241; Mature: 25110

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPRQALLDAFGVDLPDELLSLALTHRSYAYEHGGLPTNERLEFLGDAVLSLTITDELF
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEHHHHH
HRHPDRSEGDLAKLRASVVNTQALAYVARNLSDGGLGVYLLLGRGETNTGGADKSSILAD
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHH
GMESLLGAIYLHHGIEVARQVILRLFGTLLDAAPTLGAGLDWKTSLQELTAARGMGVPSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCE
VVTSTGPDHDKEFTAVVVVMDTEYGSGIGHSKKEAEQKAASAAWKALDVLGGVGKTSV
EEECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQPRQALLDAFGVDLPDELLSLALTHRSYAYEHGGLPTNERLEFLGDAVLSLTITDELF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEHHHHH
HRHPDRSEGDLAKLRASVVNTQALAYVARNLSDGGLGVYLLLGRGETNTGGADKSSILAD
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHH
GMESLLGAIYLHHGIEVARQVILRLFGTLLDAAPTLGAGLDWKTSLQELTAARGMGVPSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCE
VVTSTGPDHDKEFTAVVVVMDTEYGSGIGHSKKEAEQKAASAAWKALDVLGGVGKTSV
EEECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002