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The map label for this gene is fpg

Identifier: 221230353

GI number: 221230353

Start: 1999918

End: 2000766

Strand: Reverse

Name: fpg

Synonym: MLBr_01658

Alternate gene names: 221230353

Gene position: 2000766-1999918 (Counterclockwise)

Preceding gene: 221230354

Following gene: 221230345

Centisome position: 61.22

GC content: 60.66

Gene sequence:

>849_bases
ATGCCTGAACTGCCCGAAGTAGAGGTGGTGCGGCGCGGCCTGCAGGACTATATCGTAGGCAAGACGATTACTGCGGTTCG
GGTGCACCATCCGCGCGCTGTGCGCCGCCACGTTGCTGGACCAACTGACCTCACGAACCGGCTGCTCGGCACCCGTATTA
ACGGAATTGATCGGCGCGGCAAATATCTGTGGTTCTTGCTGGACACAGACATTGCGCTCGTGGTGCACCTCGGCATGAGC
GGGCAGATGTTGCTGGGGACCGTGCCTCGCGTCGATCACGTTAGGATCTCTGCGCTGTTCGACGACGGGACCGTGTTGAA
CTTCACGGATCAGCGGACCTTAGGGGGATGGCTGCTAGCCGATCTAATGACGGTGGACGGCAGTGTGCTGCCGGTGCCTG
TCGCCCACTTGGCGCGTGACCCGTTCGATCCGCGGTTCGATGTCGAAGCTGTAGTGAAAGTGTTGCGGTGCAAGCATTCC
GAGCTCAAGCGCCAGCTCCTCGATCAACAGACAGTATCTGGAATCGGCAACATTTACGCCGATGAGGCGTTGTGGCGGGC
CGAAGTGCACGGCGCGCGAATTGCTGCCACTCTGACCCGTCGGCAGCTGGCCGCGGTTCTGGATGCTGCCGCCGATGTGA
TGCGCGACTCGTTGGCCAAGGGTGGGACTTCGTTCGATTCGCTGTATGTCAACGTCAACGGCGAATCGGGGTACTTTGAC
CGATCTTTGGATGCCTATGGTCGTGAAGGCGAAGGCTGCCGGCGTTGCGGCGCGGTGATGCACCGGGAAAAGTTCATGAA
CCGCTCGTCCTTCTATTGCCCTAGATGCCAACCTCGGCCCCGGCGGTAG

Upstream 100 bases:

>100_bases
GAAAGCACTCGATGTGCTGGGCGGCGTCGGGAAAACGTCCGTGTAGTCGATGGTTATGATTCGCTGCGCCCGGTTTCGCC
GGGCTTGGGATCATAACTAA

Downstream 100 bases:

>100_bases
CTTCGGCCGTGCACACGTCGAGATTGACGTCGGTGTGGTGCTCTATCGAACTTTTCCATGCTGCCGTCGATCTCGGTGCG
AGGACCACCTGGTAGAAAGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MPELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLGTRINGIDRRGKYLWFLLDTDIALVVHLGMS
GQMLLGTVPRVDHVRISALFDDGTVLNFTDQRTLGGWLLADLMTVDGSVLPVPVAHLARDPFDPRFDVEAVVKVLRCKHS
ELKRQLLDQQTVSGIGNIYADEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYVNVNGESGYFD
RSLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRPRR

Sequences:

>Translated_282_residues
MPELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLGTRINGIDRRGKYLWFLLDTDIALVVHLGMS
GQMLLGTVPRVDHVRISALFDDGTVLNFTDQRTLGGWLLADLMTVDGSVLPVPVAHLARDPFDPRFDVEAVVKVLRCKHS
ELKRQLLDQQTVSGIGNIYADEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYVNVNGESGYFD
RSLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRPRR
>Mature_281_residues
PELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLGTRINGIDRRGKYLWFLLDTDIALVVHLGMSG
QMLLGTVPRVDHVRISALFDDGTVLNFTDQRTLGGWLLADLMTVDGSVLPVPVAHLARDPFDPRFDVEAVVKVLRCKHSE
LKRQLLDQQTVSGIGNIYADEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYVNVNGESGYFDR
SLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRPRR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=279, Percent_Identity=34.0501792114695, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786932, Length=284, Percent_Identity=26.056338028169, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_MYCLB (B8ZRZ2)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503769.1
- ProteinModelPortal:   B8ZRZ2
- SMR:   B8ZRZ2
- EnsemblBacteria:   EBMYCT00000087358
- GeneID:   7326774
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016359
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31516; Mature: 31384

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 268-268 BINDING 93-93 BINDING 112-112 BINDING 158-158

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLGTRINGIDRRG
CCCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
KYLWFLLDTDIALVVHLGMSGQMLLGTVPRVDHVRISALFDDGTVLNFTDQRTLGGWLLA
CEEEEEECCCEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHH
DLMTVDGSVLPVPVAHLARDPFDPRFDVEAVVKVLRCKHSELKRQLLDQQTVSGIGNIYA
HHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYVNVNGESGYFD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
RSLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRPRR
CCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLQDYIVGKTITAVRVHHPRAVRRHVAGPTDLTNRLLGTRINGIDRRG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCC
KYLWFLLDTDIALVVHLGMSGQMLLGTVPRVDHVRISALFDDGTVLNFTDQRTLGGWLLA
CEEEEEECCCEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHH
DLMTVDGSVLPVPVAHLARDPFDPRFDVEAVVKVLRCKHSELKRQLLDQQTVSGIGNIYA
HHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEALWRAEVHGARIAATLTRRQLAAVLDAAADVMRDSLAKGGTSFDSLYVNVNGESGYFD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
RSLDAYGREGEGCRRCGAVMHREKFMNRSSFYCPRCQPRPRR
CCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA