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The map label for this gene is fabD [H]

Identifier: 221230348

GI number: 221230348

Start: 1993442

End: 1994356

Strand: Direct

Name: fabD [H]

Synonym: MLBr_01653

Alternate gene names: 221230348

Gene position: 1993442-1994356 (Clockwise)

Preceding gene: 221230347

Following gene: 221230349

Centisome position: 61.0

GC content: 63.28

Gene sequence:

>915_bases
GTGATTGCGTTACTTGCACCCGGACAGGGCTCGCAGACCGAGGGAATGCTATCGCCGTGGCTGGGACTCCCCGGTGCCGC
AGACCAGATCGCGACCTGGTCGAAGGCAAGTGGCTTAGATCTGGTACGTCTAGGCACCACCGCCTCGACCGAGGAGATAA
CCGATACCGCTGTCGCTCAGCCGTTGATTGTTGCGACCACGCTGCTAGCTCATCAGGAGCTGGCCAAGCATGCCTTGTTT
GAGAATGCCCTCGACAACCTAATCGTGGCCGGACACTCCGTCGGCGAGATCGCGGCGTATTCGATCGCCGGTGTGATCGC
CGCCGATGATGCAGTGGCGCTGGCCGCAACCCGCGGCGCCGAGATGGCCAAGGCATGCGCCATCGAGCCGACCGGCATGT
CCGCTGTGCTCGGCGGTGACGAAGCCGACGTGCTGAATCGCCTCGAGGAACTTGACCTGGTTCCTGCGAACCGCAACGCC
GCCGGTCAGATTGTCGCCGCCGGTCGACTGACCGCGCTAGAAAAACTCGCCGAAGACCCGCCAGCCAGGGCCCGGGTGCG
AGCACTGGACGTGGCCGGAGCGTTCCACACCGAGTTCATGACCGCAGCTCTTGATGGCTTCGCAGAGGCGGCGGCCAGCA
TCACGATTGCCGAACCCATCGCGATGCTGCTCTCCAACCGTGACGGAAAACCGGTCGCGTCGGCAGCGACCGGTATGGAA
ACCCTGATTTCTCAGCTGACTCACCCGGCGCGCTGGGATCTGTGCAACGTAACGCTGCGTGAGCACAACGTCACGGCGAT
CGTGGAACTCCCGCCCGCAGGCGCTCTCACCGGAATCGCCAAACGCGAGCTTCGGGAAGTAACAACTTGCGCCGTCAAGT
CGCCCACAGACCTGGACAAGTTGGCGAACCTCTAA

Upstream 100 bases:

>100_bases
GCTTACCGAACAGTTTTGTAGGTTATATACAAAAACCTAAGACGAGGTTCATAATCTGTTACACCCCGCAAAACCGTCTT
CACAGTGTTTTCTTAGACAC

Downstream 100 bases:

>100_bases
CCGCCGACCCGGCAATTTGCAATGGCAGGAACAACCACACAGGTCTAAACAGCAAATCAATCCGATTTGCACACAACACA
TTACGAAGGGAAGCAGACTG

Product: malonyl CoA-[ACP] transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLGTTASTEEITDTAVAQPLIVATTLLAHQELAKHALF
ENALDNLIVAGHSVGEIAAYSIAGVIAADDAVALAATRGAEMAKACAIEPTGMSAVLGGDEADVLNRLEELDLVPANRNA
AGQIVAAGRLTALEKLAEDPPARARVRALDVAGAFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGME
TLISQLTHPARWDLCNVTLREHNVTAIVELPPAGALTGIAKRELREVTTCAVKSPTDLDKLANL

Sequences:

>Translated_304_residues
MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLGTTASTEEITDTAVAQPLIVATTLLAHQELAKHALF
ENALDNLIVAGHSVGEIAAYSIAGVIAADDAVALAATRGAEMAKACAIEPTGMSAVLGGDEADVLNRLEELDLVPANRNA
AGQIVAAGRLTALEKLAEDPPARARVRALDVAGAFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGME
TLISQLTHPARWDLCNVTLREHNVTAIVELPPAGALTGIAKRELREVTTCAVKSPTDLDKLANL
>Mature_304_residues
MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLGTTASTEEITDTAVAQPLIVATTLLAHQELAKHALF
ENALDNLIVAGHSVGEIAAYSIAGVIAADDAVALAATRGAEMAKACAIEPTGMSAVLGGDEADVLNRLEELDLVPANRNA
AGQIVAAGRLTALEKLAEDPPARARVRALDVAGAFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGME
TLISQLTHPARWDLCNVTLREHNVTAIVELPPAGALTGIAKRELREVTTCAVKSPTDLDKLANL

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=269, Percent_Identity=29.368029739777, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1787334, Length=302, Percent_Identity=31.1258278145695, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71984332, Length=291, Percent_Identity=27.1477663230241, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24665753, Length=265, Percent_Identity=28.3018867924528, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 31344; Mature: 31344

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLGTTASTEEITDTAVAQ
CEEEECCCCCCCCCCCHHHCCCCCCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHH
PLIVATTLLAHQELAKHALFENALDNLIVAGHSVGEIAAYSIAGVIAADDAVALAATRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHEECCCCEEEHHHCCH
EMAKACAIEPTGMSAVLGGDEADVLNRLEELDLVPANRNAAGQIVAAGRLTALEKLAEDP
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCC
PARARVRALDVAGAFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGME
CHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TLISQLTHPARWDLCNVTLREHNVTAIVELPPAGALTGIAKRELREVTTCAVKSPTDLDK
HHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
LANL
HCCC
>Mature Secondary Structure
MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLGTTASTEEITDTAVAQ
CEEEECCCCCCCCCCCHHHCCCCCCCHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHH
PLIVATTLLAHQELAKHALFENALDNLIVAGHSVGEIAAYSIAGVIAADDAVALAATRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHEECCCCEEEHHHCCH
EMAKACAIEPTGMSAVLGGDEADVLNRLEELDLVPANRNAAGQIVAAGRLTALEKLAEDP
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCC
PARARVRALDVAGAFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGME
CHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TLISQLTHPARWDLCNVTLREHNVTAIVELPPAGALTGIAKRELREVTTCAVKSPTDLDK
HHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
LANL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]