Click here to switch to the map view.

The map label for this gene is cobC [C]

Identifier: 221230341

GI number: 221230341

Start: 1973936

End: 1975051

Strand: Reverse

Name: cobC [C]

Synonym: MLBr_01637

Alternate gene names: 221230341

Gene position: 1975051-1973936 (Counterclockwise)

Preceding gene: 221230342

Following gene: 221230339

Centisome position: 60.43

GC content: 59.5

Gene sequence:

>1116_bases
GTGAAAGTTATCATCGAGGCTGACGGTGGGTCGAGAGGAAACCCCGGACCAGCCGGATATGGCGCAGTGGTGTGGATAGC
TGACCGTTCGGCTGTGCTGACGGAGACCAAGCAGGCAATCGGCAGAGCGACGAACAACGTCGCTGAATACCGTGCTCTAA
TAGCGGGGTTGGACGATGCTGTGAAAATGGGTGCCACCGAGGCCGAGGTCTTGATGGATTCTAAGCTGGTCGTGGAACAG
ATGTCGGGGCGGTGGAAAGTCAAGCATCCCGACTTGATTGAGTTATACGTACACGCCCAGACGTTAGCATCGCGGCTGGC
GAGTGTTAGTTATACGTGGATTCCGCGTACCCGGAATTCGCGCGCTGACCGATTGGCCAACGAAGCGATGGATGCCGCGT
CTTGCGCTGAAGGCCGAGTTGACCAAGCCGCTACGCAGCTTGCTCAGTCCACGAAAGCTGTTGCGAAGGAATCGCAAACA
GCGCCAGGTTGGACGGGTGCGCGAGGTACGCCCACCCGTCTGTTATTGCTGCGACATGGCCAGACCGAACTGTCGGTGCA
ACGTCGCTATTCGGGACGCGGTAACCCGGCACTAAATAACGTGGGTTGGCGTCAAGCTCGAGCTGCGGCGCGGTATTTTG
CGCAGCGCGGCGGCATAGCCGGAGTGGTCTCCTCGCCATTGCAACGGGCTTACGACACCGCGGCAACCGTCGCCGACTTG
CTGGGGGCCAACTTGACGGTTGATGATGATCTGATTGAAATCGATTTCGGCGCCTGGGAGGGGTTGACGTTTGCCGAGGC
CGCCGCGCGCGATCCGCAACTGCATCATTGTTGGCTGCACGACACTGCCACGTTACCGCCGGGCGGTGAAAGCTTCGATG
ATGTGCTGGGCCGGGTGTGCTCGGCGCGTGCACGGATCATCGCTGAATATCAGGGCGAAACGGTGCTGGTGGTGTCACAC
GTCACACCGATCAAGATGCTGCTGCGGCTCGCGTTGGATGCCGGGGCAGGCATCCTGTACAGGCTTCATCTTGACTTGGG
ATCGTTGAGCATTGCTGAGTTCTATCCCGATGGCGCGTCTTCGGTGCGGTTGGTGAACCAAACCGGCTACCTCTGA

Upstream 100 bases:

>100_bases
GCCGCGGAGAGCTGTCTTGCATCTCGGTGGACGTCGACGACGAAGTAGTGAAGTACCCGGAATCTGGAGCTATCCAGTTG
CTGGACAAAGGATTTTTCCA

Downstream 100 bases:

>100_bases
AGCGTGTCGGAACGATCCTCATACCCAAATCAACCAAGCGACGATTAGTGCAGACCGGGAAGTAAAATAGGTGTAAGGAT
GGCGCTCTGGTTGGTAGATG

Product: bifunctional RNase H/acid phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEYRALIAGLDDAVKMGATEAEVLMDSKLVVEQ
MSGRWKVKHPDLIELYVHAQTLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQSTKAVAKESQT
APGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADL
LGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRVCSARARIIAEYQGETVLVVSH
VTPIKMLLRLALDAGAGILYRLHLDLGSLSIAEFYPDGASSVRLVNQTGYL

Sequences:

>Translated_371_residues
MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEYRALIAGLDDAVKMGATEAEVLMDSKLVVEQ
MSGRWKVKHPDLIELYVHAQTLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQSTKAVAKESQT
APGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADL
LGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRVCSARARIIAEYQGETVLVVSH
VTPIKMLLRLALDAGAGILYRLHLDLGSLSIAEFYPDGASSVRLVNQTGYL
>Mature_371_residues
MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEYRALIAGLDDAVKMGATEAEVLMDSKLVVEQ
MSGRWKVKHPDLIELYVHAQTLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQSTKAVAKESQT
APGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADL
LGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRVCSARARIIAEYQGETVLVVSH
VTPIKMLLRLALDAGAGILYRLHLDLGSLSIAEFYPDGASSVRLVNQTGYL

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 39830; Mature: 39830

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEYRALIAGLDDA
CEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQTLASRLASVSYTWIPRTRNS
HHCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCC
RADRLANEAMDAASCAEGRVDQAATQLAQSTKAVAKESQTAPGWTGARGTPTRLLLLRHG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
QTELSVQRRYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADL
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRVC
HCCCCEECCCEEEEECCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
SARARIIAEYQGETVLVVSHVTPIKMLLRLALDAGAGILYRLHLDLGSLSIAEFYPDGAS
HHHHHHHEEECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHCCCCCC
SVRLVNQTGYL
CEEEECCCCCC
>Mature Secondary Structure
MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEYRALIAGLDDA
CEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQTLASRLASVSYTWIPRTRNS
HHCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHCEEEECCCCCCC
RADRLANEAMDAASCAEGRVDQAATQLAQSTKAVAKESQTAPGWTGARGTPTRLLLLRHG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
QTELSVQRRYSGRGNPALNNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADL
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LGANLTVDDDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRVC
HCCCCEECCCEEEEECCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
SARARIIAEYQGETVLVVSHVTPIKMLLRLALDAGAGILYRLHLDLGSLSIAEFYPDGAS
HHHHHHHEEECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHCCCCCC
SVRLVNQTGYL
CEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]