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The map label for this gene is htpG [H]

Identifier: 221230332

GI number: 221230332

Start: 1945431

End: 1947401

Strand: Direct

Name: htpG [H]

Synonym: MLBr_01623

Alternate gene names: 221230332

Gene position: 1945431-1947401 (Clockwise)

Preceding gene: 221230321

Following gene: 221230333

Centisome position: 59.53

GC content: 54.85

Gene sequence:

>1971_bases
ATGAGCGCACAAGTCGAACAGCTGGAGTTTCAGGCGGAGGCACGCCAACTTCTGGACTTGATGGTCCATTCGGTCTACTC
CAATAAAGATGCATTTTTGCGGGAGCTGATCTCGAATGCCTCCGACGCGCTGGACAAGCTTCGGCTTGAAGCGTTTCGGA
ACAAAGACTTGGACCCACGTACAGTTGACACCTCCGATCTGCACATCGAGATCGAAGTGGACAAAAATACACGCATTTTA
ACCGTCCGTGACAACGGCATAGGTATGACACGCGCGGAGGTGGTGGACTTGATCGGTACACTGGCCAAGTCAGGGACCGC
CAAGCTGCGTCAGAAATTGCATGCGGCCAAAAATCTGAAAGACACCGCCGCCTCTGAAGGACTGATCGGTCAGTTCGGTA
TCGGTTTTTACTCGAGTTTCATGGTAGCCAACAAGGTCGAACTTCTCACCCGTAAAGCCGGTGAGACTGCGGCCACGAGA
TGGTCATCGGACGGTGAGGCCACCTACACCATCGAATCCGTCGACGAAGCTCCGCAGGGAACATCAGTGACGTTGCACCT
CAAACCCGAAGACTTCGAGGACGAGTTGCACGACTACACCTCGGAATGGAAGATCAGGGAGCTGGTCAAGAAGTACTCCG
ACTTCATCGCCTGGCCTATCCGGATGGAAGTTGAGCGACGCGCGCCGGCCACCTCGGACGGAGAAGGGGCGGATGGTGAA
GAGCAAGTCACCATCGAAACCCAGACCATCAACTCAATGAAGGCGTTGTGGACTAAGTCAAAAGACGAGGTCTCAGAGGA
CGAATACAAGGAGTTCTACAAGCACATCGCCCACGCCTGGGATGACCCACTCGAGGTGATCGCGATGAAGGCCGAGGGCA
CCTTCGAGTACCAGGCGCTGCTTTTTATTCCTTCGCACGCTCCGTTCGACCTGTTTAACTCCGACGCCAAAATCGGCATG
CAGCTGTATGTCAAACGCGTCTTCATCATGTCCGACTGCGATCAGCTCATGCCGATGTACTTGCGTTTCGTCAAAGGGGT
TGTAGACGCAGAGGACATGTCGCTCAATGTTTCTCGAGAAATCCTGCAACAGAATCGGCAAATCAATGCGATCCGTCGCC
GGCTGACCAAGAAGGTCCTTTCAGCAATCAAAGATCTGCAGGCCGAACGACCACAGGACTACCGCACGTTCTGGACACAG
TTCGGCAAGGTCCTCAAAGAGGGACTCATGTCGGACTCCGACAATCGAGACACACTGCTTCACATTTCCTCGTTCGCCTC
GACACACAGCGACGAAGAACCCACCACCCTGGCCCAATACGTAGAACGCATGAAAGACGGCCAAGACCAAATCTTCTACG
CCACAGGAGAGTCGCGTCAGCAAGTCATGAATTCGCCACATCTCGAAGCATTCAAGGCCAAGGGCTATGAGGTGCTGTTG
CTGACCGACCCGGTCGACGAGGTTTGGGTAGGAATGGCACCCGAGTTCGACGGCAAGCCGTTGAAATCGGTAGCTAGGGG
CGAGGTGGACCTCGAATCCGAAGAGGAAAAGACAGCGCACGAAGCTGAACGCAAGGAGCAGGAGCAGAATTTTGCTGGGC
TGGTGAACTGGTTGAAAGAGACCTTGAGTGATCACGTCAAAGAGGTACGGTTATCCACACGCCTCACCGAGTCGCCAGCC
TGCCTGATCACTGATGCCTTCGGTATTACGCCGGCGCTGGCGCGCATCTACCGGGCTTCCGGGCAGGACGTTCCGTTCGG
AAAACGGATTTTGGAACTCAATCCAAATCATCCACTGATCACTGGCCTGCAACAGGCACACGAGAACGGCGGTGATGATA
CTCACCTGCGTCAACTCTCCGAAACTGCCGAATTGTTGTACGGTACCGCCCTTCTCACTGAAGGCGGAGCACTAGAGAAT
CCGGCAAAGTTCGCCGGATTGCTCGCGGATCTTCTGTCCCGGTCGATGTAG

Upstream 100 bases:

>100_bases
AGCGGCGCCAGTCATGTCCGAGCCAGGCGCAGCGGATCGATCATCGTCTGGGTATAACTGGTCCTGTGGATTTGCAGGTT
ACCTCGTCGGACGGATTGAC

Downstream 100 bases:

>100_bases
GAAACGCCACAAAGGTCATAAGCATGCTGAAAAATGTTGTCGTTCTATGTTTTACAGTCATCACCTGACCGCACTGGCGT
GTACCACTGTATCCATCGTA

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MSAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPRTVDTSDLHIEIEVDKNTRIL
TVRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLKDTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATR
WSSDGEATYTIESVDEAPQGTSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGE
EQVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNSDAKIGM
QLYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSREILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQ
FGKVLKEGLMSDSDNRDTLLHISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLL
LTDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKETLSDHVKEVRLSTRLTESPA
CLITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLITGLQQAHENGGDDTHLRQLSETAELLYGTALLTEGGALEN
PAKFAGLLADLLSRSM

Sequences:

>Translated_656_residues
MSAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPRTVDTSDLHIEIEVDKNTRIL
TVRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLKDTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATR
WSSDGEATYTIESVDEAPQGTSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGE
EQVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNSDAKIGM
QLYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSREILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQ
FGKVLKEGLMSDSDNRDTLLHISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLL
LTDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKETLSDHVKEVRLSTRLTESPA
CLITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLITGLQQAHENGGDDTHLRQLSETAELLYGTALLTEGGALEN
PAKFAGLLADLLSRSM
>Mature_655_residues
SAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPRTVDTSDLHIEIEVDKNTRILT
VRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLKDTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATRW
SSDGEATYTIESVDEAPQGTSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGEE
QVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNSDAKIGMQ
LYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSREILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQF
GKVLKEGLMSDSDNRDTLLHISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLLL
TDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKETLSDHVKEVRLSTRLTESPAC
LITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLITGLQQAHENGGDDTHLRQLSETAELLYGTALLTEGGALENP
AKFAGLLADLLSRSM

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI20149594, Length=681, Percent_Identity=37.8854625550661, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI4507677, Length=695, Percent_Identity=37.6978417266187, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI155722983, Length=662, Percent_Identity=30.5135951661631, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI154146191, Length=415, Percent_Identity=38.7951807228916, Blast_Score=296, Evalue=5e-80,
Organism=Homo sapiens, GI153792590, Length=415, Percent_Identity=38.7951807228916, Blast_Score=293, Evalue=4e-79,
Organism=Escherichia coli, GI1786679, Length=647, Percent_Identity=45.5950540958269, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17559162, Length=687, Percent_Identity=39.155749636099, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17542208, Length=696, Percent_Identity=36.7816091954023, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI115535205, Length=675, Percent_Identity=31.4074074074074, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI115535167, Length=456, Percent_Identity=32.6754385964912, Blast_Score=238, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6323840, Length=691, Percent_Identity=38.4949348769899, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6325016, Length=695, Percent_Identity=38.1294964028777, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17647529, Length=690, Percent_Identity=37.6811594202899, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI21357739, Length=702, Percent_Identity=35.7549857549858, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24586016, Length=665, Percent_Identity=33.3834586466165, Blast_Score=349, Evalue=3e-96,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 73897; Mature: 73766

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TVDTSDLHIEIEVDKNTRILTVRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLK
CCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
DTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATRWSSDGEATYTIESVDEAPQG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCC
TSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGE
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCC
EQVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQAL
CEEEEEHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCHHEEEEECCCCEEEEEE
LFIPSHAPFDLFNSDAKIGMQLYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSRE
EEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQFGKVLKEGLMSDSDNRDTLL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
HISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLL
EEHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHCCCEEEEE
LTDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKE
EECCHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSDHVKEVRLSTRLTESPACLITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLI
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCHH
TGLQQAHENGGDDTHLRQLSETAELLYGTALLTEGGALENPAKFAGLLADLLSRSM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLEAFRNKDLDPR
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TVDTSDLHIEIEVDKNTRILTVRDNGIGMTRAEVVDLIGTLAKSGTAKLRQKLHAAKNLK
CCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
DTAASEGLIGQFGIGFYSSFMVANKVELLTRKAGETAATRWSSDGEATYTIESVDEAPQG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCCCCC
TSVTLHLKPEDFEDELHDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGE
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCC
EQVTIETQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFEYQAL
CEEEEEHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCHHEEEEECCCCEEEEEE
LFIPSHAPFDLFNSDAKIGMQLYVKRVFIMSDCDQLMPMYLRFVKGVVDAEDMSLNVSRE
EEECCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
ILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRTFWTQFGKVLKEGLMSDSDNRDTLL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
HISSFASTHSDEEPTTLAQYVERMKDGQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLL
EEHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCHHHHHCCCEEEEE
LTDPVDEVWVGMAPEFDGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKE
EECCHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSDHVKEVRLSTRLTESPACLITDAFGITPALARIYRASGQDVPFGKRILELNPNHPLI
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCHH
TGLQQAHENGGDDTHLRQLSETAELLYGTALLTEGGALENPAKFAGLLADLLSRSM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]