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The map label for this gene is lepB

Identifier: 221230325

GI number: 221230325

Start: 1936089

End: 1936958

Strand: Reverse

Name: lepB

Synonym: MLBr_01612

Alternate gene names: 221230325

Gene position: 1936958-1936089 (Counterclockwise)

Preceding gene: 221230326

Following gene: 221230324

Centisome position: 59.27

GC content: 59.2

Gene sequence:

>870_bases
GTGACCGAAACCACGGACTCCGTACCTGAACCTCCGTCCGACGCTGACCAGTTGCAGCCGAAGGTGTCTATCTGTGGTCT
TGATATGCCCGCTGAAGTATCTGAGACTGCCGCGGAAGCCGCAATAGGCGTGTCGGAGCCCAAGAAGCGTTCGGCGTTGT
GGGAATTCGCGATTTTGGCGGTGATCGCTATAGGCTTGTACTACGTCATGTTGACGTTCGTGGCACGCCCCTACCTGATT
CCGTCGGAATCCATGGAGCCCACGCTGCACGGATGCTCGGGCTGTGTGGGCGACCGCATCATGGTGGATAAGATCACTTA
TCGCTTCAGCTCACCACAACCTGGTGACGTCATCGTCTTCAAGGGCCCGCCGTCGTGGAACACGATGTACAAATCTATCC
GGTCAAACAACATCGTGCTGCGCTCGGTGCAAAACGCGTTGTCGTTCGTCGGTTTCGTGCCTCCCGACGAGAACGACTTG
GTCAAGCGCGTTATCGCGGTCGGAGGACAGACGGTGCAGTGCCGGTCCGACACGGGCTTGACGGTCAATGGGAAGCCACT
CAAAGAGCCGTATCTCAGGCCGGTCACCATGAATGCCGACCTGTCATTCTCCCCGTGCCTGGGTAGCGAGTTCGGTCCAG
TCACGGTCCCGCAGGGACGCCTGTGGGTTATGGGTGATAACCGGATACACTCCGCGGACTCGCGTTACCACTGCAACTCC
ACCGACGTGGTGAATGGGCTTTCGTGCACCGGTGATCCGAATTCGGGGACTGTGCCGGTGTCCAATGTCATCGGTAAGGC
CAGGGTCGTCGTGTGGCCGCCGTCACGATGGGGTGGTGTGGGTTCGGTGAATTCCCAGCAGGGGCAGTAG

Upstream 100 bases:

>100_bases
AAGATCAAGGAGAAGCGCTGACTGGGGTACACCCTGGTTGCCGGTCGTGCCGCCTCGGTGTCGCATTAGGCCACACACTA
CGCTGGCTACGCTGATCATC

Downstream 100 bases:

>100_bases
CCATGGCCACCACCTGGCCGCCGTGCAGGATAATCCGTAAGTCTGGGGGTTTGCGGGGGATGTGGACTCTAGAGTACGAA
CTGCAGCGCAGCGGGTTGGG

Product: putative ignal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTETTDSVPEPPSDADQLQPKVSICGLDMPAEVSETAAEAAIGVSEPKKRSALWEFAILAVIAIGLYYVMLTFVARPYLI
PSESMEPTLHGCSGCVGDRIMVDKITYRFSSPQPGDVIVFKGPPSWNTMYKSIRSNNIVLRSVQNALSFVGFVPPDENDL
VKRVIAVGGQTVQCRSDTGLTVNGKPLKEPYLRPVTMNADLSFSPCLGSEFGPVTVPQGRLWVMGDNRIHSADSRYHCNS
TDVVNGLSCTGDPNSGTVPVSNVIGKARVVVWPPSRWGGVGSVNSQQGQ

Sequences:

>Translated_289_residues
MTETTDSVPEPPSDADQLQPKVSICGLDMPAEVSETAAEAAIGVSEPKKRSALWEFAILAVIAIGLYYVMLTFVARPYLI
PSESMEPTLHGCSGCVGDRIMVDKITYRFSSPQPGDVIVFKGPPSWNTMYKSIRSNNIVLRSVQNALSFVGFVPPDENDL
VKRVIAVGGQTVQCRSDTGLTVNGKPLKEPYLRPVTMNADLSFSPCLGSEFGPVTVPQGRLWVMGDNRIHSADSRYHCNS
TDVVNGLSCTGDPNSGTVPVSNVIGKARVVVWPPSRWGGVGSVNSQQGQ
>Mature_288_residues
TETTDSVPEPPSDADQLQPKVSICGLDMPAEVSETAAEAAIGVSEPKKRSALWEFAILAVIAIGLYYVMLTFVARPYLIP
SESMEPTLHGCSGCVGDRIMVDKITYRFSSPQPGDVIVFKGPPSWNTMYKSIRSNNIVLRSVQNALSFVGFVPPDENDLV
KRVIAVGGQTVQCRSDTGLTVNGKPLKEPYLRPVTMNADLSFSPCLGSEFGPVTVPQGRLWVMGDNRIHSADSRYHCNST
DVVNGLSCTGDPNSGTVPVSNVIGKARVVVWPPSRWGGVGSVNSQQGQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEP_MYCLE (O33021)

Other databases:

- EMBL:   Z97369
- EMBL:   AL583922
- PIR:   F87110
- RefSeq:   NP_302111.1
- ProteinModelPortal:   O33021
- MEROPS:   S26.024
- EnsemblBacteria:   EBMYCT00000028960
- GeneID:   909308
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1612
- NMPDR:   fig|272631.1.peg.983
- Leproma:   ML1612
- GeneTree:   EBGT00050000017115
- HOGENOM:   HBG596607
- OMA:   TVECCDD
- ProtClustDB:   CLSK792152
- BioCyc:   MLEP272631:ML1612-MONOMER
- BRENDA:   3.4.21.89
- GO:   GO:0006508
- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- Gene3D:   G3DSA:2.10.109.10
- PRINTS:   PR00727
- TIGRFAMs:   TIGR02227

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.89

Molecular weight: Translated: 31087; Mature: 30956

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00501 SPASE_I_1; PS00760 SPASE_I_2; PS00761 SPASE_I_3

Important sites: ACT_SITE 84-84 ACT_SITE 162-162

Signals:

None

Transmembrane regions:

HASH(0x2a36813c)-;

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTDSVPEPPSDADQLQPKVSICGLDMPAEVSETAAEAAIGVSEPKKRSALWEFAILA
CCCCCCCCCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VIAIGLYYVMLTFVARPYLIPSESMEPTLHGCSGCVGDRIMVDKITYRFSSPQPGDVIVF
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEEEECCCCCCCEEEE
KGPPSWNTMYKSIRSNNIVLRSVQNALSFVGFVPPDENDLVKRVIAVGGQTVQCRSDTGL
CCCCCHHHHHHHHCCCCEEHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCEEEEECCCCE
TVNGKPLKEPYLRPVTMNADLSFSPCLGSEFGPVTVPQGRLWVMGDNRIHSADSRYHCNS
EECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCCEEEEEECCEEECCCCCEECCC
TDVVNGLSCTGDPNSGTVPVSNVIGKARVVVWPPSRWGGVGSVNSQQGQ
CCCCCCEECCCCCCCCCEEHHHHCCCEEEEEECCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
TETTDSVPEPPSDADQLQPKVSICGLDMPAEVSETAAEAAIGVSEPKKRSALWEFAILA
CCCCCCCCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VIAIGLYYVMLTFVARPYLIPSESMEPTLHGCSGCVGDRIMVDKITYRFSSPQPGDVIVF
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEEEECCCCCCCEEEE
KGPPSWNTMYKSIRSNNIVLRSVQNALSFVGFVPPDENDLVKRVIAVGGQTVQCRSDTGL
CCCCCHHHHHHHHCCCCEEHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCEEEEECCCCE
TVNGKPLKEPYLRPVTMNADLSFSPCLGSEFGPVTVPQGRLWVMGDNRIHSADSRYHCNS
EECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCCEEEEEECCEEECCCCCEECCC
TDVVNGLSCTGDPNSGTVPVSNVIGKARVVVWPPSRWGGVGSVNSQQGQ
CCCCCCEECCCCCCCCCEEHHHHCCCEEEEEECCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002