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The map label for this gene is xerC

Identifier: 221230316

GI number: 221230316

Start: 1924770

End: 1925663

Strand: Reverse

Name: xerC

Synonym: MLBr_01600

Alternate gene names: 221230316

Gene position: 1925663-1924770 (Counterclockwise)

Preceding gene: 221230317

Following gene: 221230315

Centisome position: 58.92

GC content: 66.89

Gene sequence:

>894_bases
GTGGCGATCCTCGACGAGTTCGATGAGCACCTAGCGCTGCGGTGCGGTCGCTCAGAGCATACCCGTCGTGCATATCTGGG
CGACCTGCGGTCGTTGTTGACCCATCTAGAGGGACGTGGGTCCAGGCTAGATCAACTGAGCCTGCCGGTGCTGCGGTCGT
GGCTGGCTACGGCGGCCGGTGCCGGCGCGGCTCGCACCACGTTGGCCCGTCGCATCTCGGCGGTCAAGGCATTCACCGCG
TGGGCGAAGTGGCGTGGCCAACTTGCGGCCGACCCCGCCGCGCGGTTACAGGTGCCTAGGGCGTATCGCACCCTGCCGGC
GGTGCTGCGTCAGGATCAGGCGTTGCAGATCATGGCGGCCGCAAAATCCGGCGCCGAGCAGGGTGATCCTCTGGCTTTGC
GGGACCGGTTGATCGTAGAAATGTTGTACGCCACCGGCATCCGGGTGAGTGAGTTGTGCGGCTTGGACATCGACGATGTG
GACACCCGGCACCGGCTGGTGCGTGTCCTGGGTAAGGGCAATAAACAGCGCACCGCGCCGTTTGGGGTACCGGCCGCTGA
CGCGCTGCGCGGCTGGCTGGACGACGGGCGCCCGGCTTTGGTCACCGTAGAGTCCGGGCCAGCACTACTCCTGGGATCAC
GGGGGCGACGGCTCGACGTGCGCCAGGCCCGCACGGTGGTGCACCAAACCGTGGCCGTGGTAGCCGGTGCACCCGACATG
GGACCGCATGGGCTGCGGCACAGCGCAGCCACTCATTTGCTTGAAGGCGGTGCTGACCTGCGTGTCGTCCAGGAATTGCT
AGGGCATTCCAGTCTGGCGACCACCCAACTGTACACCCACGTGGCGGTCTCACGGCTGCGTGTGGTGCACGACCAGGCTC
ACCCGCGGGCGTGA

Upstream 100 bases:

>100_bases
ACAAAAACTTCGGATGGTAACGTCACGACAACAGTTCGGCGCGTCTACAGCGAAACGCCGTGCTGAATCTGCAAACGTAA
GTCGAGTGTCGGACCACAGC

Downstream 100 bases:

>100_bases
TGCTGTCAATGGTTCAGCGGTTTGAGTCGGATGGCAGTCGATATTTAAGATTTAAGCAGGCTCAGCAGATCGGCATAATC
AGCGTCGGACGCCGGACCCC

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAILDEFDEHLALRCGRSEHTRRAYLGDLRSLLTHLEGRGSRLDQLSLPVLRSWLATAAGAGAARTTLARRISAVKAFTA
WAKWRGQLAADPAARLQVPRAYRTLPAVLRQDQALQIMAAAKSGAEQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDV
DTRHRLVRVLGKGNKQRTAPFGVPAADALRGWLDDGRPALVTVESGPALLLGSRGRRLDVRQARTVVHQTVAVVAGAPDM
GPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRVVHDQAHPRA

Sequences:

>Translated_297_residues
MAILDEFDEHLALRCGRSEHTRRAYLGDLRSLLTHLEGRGSRLDQLSLPVLRSWLATAAGAGAARTTLARRISAVKAFTA
WAKWRGQLAADPAARLQVPRAYRTLPAVLRQDQALQIMAAAKSGAEQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDV
DTRHRLVRVLGKGNKQRTAPFGVPAADALRGWLDDGRPALVTVESGPALLLGSRGRRLDVRQARTVVHQTVAVVAGAPDM
GPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRVVHDQAHPRA
>Mature_296_residues
AILDEFDEHLALRCGRSEHTRRAYLGDLRSLLTHLEGRGSRLDQLSLPVLRSWLATAAGAGAARTTLARRISAVKAFTAW
AKWRGQLAADPAARLQVPRAYRTLPAVLRQDQALQIMAAAKSGAEQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVD
TRHRLVRVLGKGNKQRTAPFGVPAADALRGWLDDGRPALVTVESGPALLLGSRGRRLDVRQARTVVHQTVAVVAGAPDMG
PHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRVVHDQAHPRA

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=299, Percent_Identity=40.8026755852843, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1790244, Length=253, Percent_Identity=37.9446640316205, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1790767, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790768, Length=154, Percent_Identity=27.9220779220779, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_MYCLE (Q9CBU0)

Other databases:

- EMBL:   Z97369
- EMBL:   AL583922
- PIR:   B87109
- RefSeq:   NP_302102.1
- ProteinModelPortal:   Q9CBU0
- SMR:   Q9CBU0
- EnsemblBacteria:   EBMYCT00000028766
- GeneID:   909806
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1600
- NMPDR:   fig|272631.1.peg.974
- Leproma:   ML1600
- GeneTree:   EBGT00050000015380
- HOGENOM:   HBG727654
- OMA:   GRRINPR
- ProtClustDB:   PRK00236
- BioCyc:   MLEP272631:ML1600-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 32180; Mature: 32049

Theoretical pI: Translated: 11.05; Mature: 11.05

Prosite motif: NA

Important sites: ACT_SITE 148-148 ACT_SITE 172-172 ACT_SITE 243-243 ACT_SITE 246-246 ACT_SITE 269-269 ACT_SITE 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILDEFDEHLALRCGRSEHTRRAYLGDLRSLLTHLEGRGSRLDQLSLPVLRSWLATAAG
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
AGAARTTLARRISAVKAFTAWAKWRGQLAADPAARLQVPRAYRTLPAVLRQDQALQIMAA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHH
AKSGAEQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVDTRHRLVRVLGKGNKQRTAP
HHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
FGVPAADALRGWLDDGRPALVTVESGPALLLGSRGRRLDVRQARTVVHQTVAVVAGAPDM
CCCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCC
GPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRVVHDQAHPRA
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AILDEFDEHLALRCGRSEHTRRAYLGDLRSLLTHLEGRGSRLDQLSLPVLRSWLATAAG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
AGAARTTLARRISAVKAFTAWAKWRGQLAADPAARLQVPRAYRTLPAVLRQDQALQIMAA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHH
AKSGAEQGDPLALRDRLIVEMLYATGIRVSELCGLDIDDVDTRHRLVRVLGKGNKQRTAP
HHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
FGVPAADALRGWLDDGRPALVTVESGPALLLGSRGRRLDVRQARTVVHQTVAVVAGAPDM
CCCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCC
GPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQLYTHVAVSRLRVVHDQAHPRA
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002