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The map label for this gene is fbiC

Identifier: 221230262

GI number: 221230262

Start: 1797541

End: 1800132

Strand: Reverse

Name: fbiC

Synonym: MLBr_01492

Alternate gene names: 221230262

Gene position: 1800132-1797541 (Counterclockwise)

Preceding gene: 221230263

Following gene: 221230261

Centisome position: 55.08

GC content: 59.95

Gene sequence:

>2592_bases
TTGTGGGGAAGTTACACCAAAGTGTCGCTGATTGAAAGCCAGGAGCCCATCGCTCTTTCTCGCCCTGTCGTTCCACCCAA
GCCTAATACGTCGGCGCTGCGGCGGGTATTGCGCCGAGCTCGAGACGGTTTCGCGCTGAATATCGATGAGGCGGTCGTTG
CGATGACCGCACGTGGTGAGGATCTGGCTGACCTTTGTGCCAGTGCTGCTCGGGTACGCGACGTAGGTCTCGAAACGGCT
GGGCGACGCGGTGCAGACGGCCGGTTGCCGATTACCTATTCGAGGAAGGTGTTCATCCCCGTCACCCATCTGTGCCGCGA
CAGCTGCCACTACTGCACTTTCGTCACCGCCCCAGACATGCTGCGTACCCAAGGTGCTGGGATGTACTTGGAACCCAACG
AAATTCTCAATCTAGCTCGTCGTGGGAGTGAACTTGGTTGCAAGGAGGCACTATTCACCCTCGGTGACCGGCCTGAGGAT
CGCTGGGCGCAAGCTCGTGACTGGCTCGCTGAACGGGGTTATGATTCCACGTTGTCCTATTTGCGGGCGATGGCGATTCG
CGTGTTGGAGGAGACCGGCCTATTGCCGCATTTGAATCCTGGCGTGATGAGTTGGTCTGAGCTGTCGCGGCTCAAACCGG
TGGCGCCTTCGATGGGTATGATGCTGGAGACGACGTCACGACGATTATTCGAAACAAAAGGCCTCGCGCACTACGGCAGT
CTGGACAAAGATCCGACGGTGCGGTTGCGGGTGCTGACTGATGCGGGTCGGTTGTCCATACCGTTCACCACCGGTCTGCT
GGTCGGCATCGGCGAGACGTTGGCCGAGCGTGCCGATACGTTGCACGAGATCCGCAAGTCGAACAAGGAGTTCGGCCATG
TCCAGGAAGTAATCGTGCAGAATTTCCGGGCCAAGGAACACACTGCGATGGCTGCGGTTCCGGATGCCAGGATCGAGGAT
TACCTAGCAACCGTGGCTGTTGCTCGGCTGGTACTGGGTCCAGCTATGCGTATTCAGGCGCCGCCGAACCTGGTGTCGCG
CGAGGAGTGTCTCGCGTTGGTTACTGCCGGTGTTGACGACTGGGGCGGTGTCTCACCACTGACACCCGACCATGTCAATC
CGGAACGACCCTGGCCTGCTTTGCATGAATTGGCTGCTGTCACAGCGGAGGCCGGTTATACCCTGGTGCAGCGGTTGACT
GCCCAACCTAAATACGTGCAGGCAGGTGCCGCATGGATCGACCCACGAGTGCGGGGTCATGTTGTGGCACTGGCTGATCC
GGTGACCGGCTTGGCTCGCGATGTCAATCCGGTCGGCATGCCCTGGCAGGAGCCCGACGATGTGGAGTCCGCCGGTCGGA
TGGATATCAATACAGCGATCGACACCGAGGGCCGCAACACCGAAGCCCGTAGCGACCTCGACAGCGCATTCGGTGATTGG
GAATCAATCCGTGCCCACGTGCACGAGTTGGCCGACTGCGCCCCGGAGCGCATCGATACCGATGTGCTCGCTGCACTTCG
CTCAGCTGAGCGTGATCCCGCCGGTTGCACTGACGACGAGTATCTGGCGTTGGCCACCGCCGACGGTCCTGCACTGGAAG
CTGTTACTGCACTTGCAGATTCGTTGCGCCGGGATGTGGTCGGTGATGATGTGACGTTCGTGGTGAATCGTAACATTAAC
TTCACCAATATCTGTTACACCGGCTGTCGGTTCTGTGCGTTCGCCCAACGCAAGGGTGACACCGATGCCTACTCGTTGTC
TAGAGAGGAGGTCGCTGAACGCGCATGGGAGGCACACGTCCAGGGTGCCACCGAGGTATGTATGCAGGGTGGTATCGACC
CCGAGCTACCGGTCACTGGCTACGTCGATCTGGTGCGCGCCGTCAAAACCCGGGTCCCTTCGATGCATGTGCACGCGTTT
TCCCCGATGGAGATCGCCAACGGTGTGGCCAAGAGTGGTTTTAGTATTCGTGAGTGGCTGATCAGTTTGCGTGAGGCTGG
CTTGGATACCATTCCCGGCACCGCCGCCGAAATCCTGGATGATGAAGTGCGCTGGGTACTAACTAAGGGCAAGTTGCCGA
CGTCGATGTGGATCGAGATCGTCACCACGGCCCATGAGGTGGGTTTACGCTCTTCGTCGACCATGATGTACGGCCATGTC
GACGGGCCACGCCACTGGGTGGCTCACCTACAAGTCCTGCGCGATATCCAGGATCGCACCGGTGGCTTCACCGAATTTGT
GCCATTGCCTTTCGTGCACCAGAATTCGCCGTTGTACCTGGCCGGAGCAGCTCGTCCGGGGCCCACCCATCGTGACAACC
GTGCCGTTCATGCCCTGGCGCGAATTATGCTGCACGGCCGTATCTCTCACATTCAAACTAGCTGGGTGAAGCTTGGCGTG
GAGCGCACGCAGGCAATGCTTAACGGGGGCGCCAACGACCTAGGAGGCACGTTGATGGAGGAGACCATCTCGCGGATGGC
CGGTTCTGAATACGGTTCCGCCAAGACCGTCGCCGAGTTGATAGCGATCGCGGAGGGCATCGGCCGCACCGCCCGCCAGC
GCACCACCACCTACGCCCTGCGAGGGGCTTAA

Upstream 100 bases:

>100_bases
CTCGTTGCGCGGCGATGACAGCGGGATACTCGACCGCGTGCCAGCTGTGGCTTGGCGCTAGTGTTGCGAATATGTTTGGG
ACGTCGTGGATGGAATTTGA

Downstream 100 bases:

>100_bases
ATCTTTTATCCGCGAGGGCGGGTGTTCTCTTCTCCCGCAAGCGGGAGGTGTCCCAGTCTAGTGGCGTGACGTGAATACGA
TACTTGGCACAACCTTTGTC

Product: FO synthase

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

Number of amino acids: Translated: 863; Mature: 863

Protein sequence:

>863_residues
MWGSYTKVSLIESQEPIALSRPVVPPKPNTSALRRVLRRARDGFALNIDEAVVAMTARGEDLADLCASAARVRDVGLETA
GRRGADGRLPITYSRKVFIPVTHLCRDSCHYCTFVTAPDMLRTQGAGMYLEPNEILNLARRGSELGCKEALFTLGDRPED
RWAQARDWLAERGYDSTLSYLRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGS
LDKDPTVRLRVLTDAGRLSIPFTTGLLVGIGETLAERADTLHEIRKSNKEFGHVQEVIVQNFRAKEHTAMAAVPDARIED
YLATVAVARLVLGPAMRIQAPPNLVSREECLALVTAGVDDWGGVSPLTPDHVNPERPWPALHELAAVTAEAGYTLVQRLT
AQPKYVQAGAAWIDPRVRGHVVALADPVTGLARDVNPVGMPWQEPDDVESAGRMDINTAIDTEGRNTEARSDLDSAFGDW
ESIRAHVHELADCAPERIDTDVLAALRSAERDPAGCTDDEYLALATADGPALEAVTALADSLRRDVVGDDVTFVVNRNIN
FTNICYTGCRFCAFAQRKGDTDAYSLSREEVAERAWEAHVQGATEVCMQGGIDPELPVTGYVDLVRAVKTRVPSMHVHAF
SPMEIANGVAKSGFSIREWLISLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIEIVTTAHEVGLRSSSTMMYGHV
DGPRHWVAHLQVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPTHRDNRAVHALARIMLHGRISHIQTSWVKLGV
ERTQAMLNGGANDLGGTLMEETISRMAGSEYGSAKTVAELIAIAEGIGRTARQRTTTYALRGA

Sequences:

>Translated_863_residues
MWGSYTKVSLIESQEPIALSRPVVPPKPNTSALRRVLRRARDGFALNIDEAVVAMTARGEDLADLCASAARVRDVGLETA
GRRGADGRLPITYSRKVFIPVTHLCRDSCHYCTFVTAPDMLRTQGAGMYLEPNEILNLARRGSELGCKEALFTLGDRPED
RWAQARDWLAERGYDSTLSYLRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGS
LDKDPTVRLRVLTDAGRLSIPFTTGLLVGIGETLAERADTLHEIRKSNKEFGHVQEVIVQNFRAKEHTAMAAVPDARIED
YLATVAVARLVLGPAMRIQAPPNLVSREECLALVTAGVDDWGGVSPLTPDHVNPERPWPALHELAAVTAEAGYTLVQRLT
AQPKYVQAGAAWIDPRVRGHVVALADPVTGLARDVNPVGMPWQEPDDVESAGRMDINTAIDTEGRNTEARSDLDSAFGDW
ESIRAHVHELADCAPERIDTDVLAALRSAERDPAGCTDDEYLALATADGPALEAVTALADSLRRDVVGDDVTFVVNRNIN
FTNICYTGCRFCAFAQRKGDTDAYSLSREEVAERAWEAHVQGATEVCMQGGIDPELPVTGYVDLVRAVKTRVPSMHVHAF
SPMEIANGVAKSGFSIREWLISLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIEIVTTAHEVGLRSSSTMMYGHV
DGPRHWVAHLQVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPTHRDNRAVHALARIMLHGRISHIQTSWVKLGV
ERTQAMLNGGANDLGGTLMEETISRMAGSEYGSAKTVAELIAIAEGIGRTARQRTTTYALRGA
>Mature_863_residues
MWGSYTKVSLIESQEPIALSRPVVPPKPNTSALRRVLRRARDGFALNIDEAVVAMTARGEDLADLCASAARVRDVGLETA
GRRGADGRLPITYSRKVFIPVTHLCRDSCHYCTFVTAPDMLRTQGAGMYLEPNEILNLARRGSELGCKEALFTLGDRPED
RWAQARDWLAERGYDSTLSYLRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGS
LDKDPTVRLRVLTDAGRLSIPFTTGLLVGIGETLAERADTLHEIRKSNKEFGHVQEVIVQNFRAKEHTAMAAVPDARIED
YLATVAVARLVLGPAMRIQAPPNLVSREECLALVTAGVDDWGGVSPLTPDHVNPERPWPALHELAAVTAEAGYTLVQRLT
AQPKYVQAGAAWIDPRVRGHVVALADPVTGLARDVNPVGMPWQEPDDVESAGRMDINTAIDTEGRNTEARSDLDSAFGDW
ESIRAHVHELADCAPERIDTDVLAALRSAERDPAGCTDDEYLALATADGPALEAVTALADSLRRDVVGDDVTFVVNRNIN
FTNICYTGCRFCAFAQRKGDTDAYSLSREEVAERAWEAHVQGATEVCMQGGIDPELPVTGYVDLVRAVKTRVPSMHVHAF
SPMEIANGVAKSGFSIREWLISLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIEIVTTAHEVGLRSSSTMMYGHV
DGPRHWVAHLQVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPTHRDNRAVHALARIMLHGRISHIQTSWVKLGV
ERTQAMLNGGANDLGGTLMEETISRMAGSEYGSAKTVAELIAIAEGIGRTARQRTTTYALRGA

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the radical SAM superfamily. CofH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FBIC_MYCLE (Q9CBX6)

Other databases:

- EMBL:   AL583922
- PIR:   E87095
- RefSeq:   NP_302048.1
- ProteinModelPortal:   Q9CBX6
- EnsemblBacteria:   EBMYCT00000029111
- GeneID:   909524
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1492
- NMPDR:   fig|272631.1.peg.920
- Leproma:   ML1492
- GeneTree:   EBGT00050000016725
- HOGENOM:   HBG335564
- OMA:   RAGIDDW
- ProtClustDB:   PRK09234
- BioCyc:   MLEP272631:ML1492-MONOMER
- HAMAP:   MF_01611
- HAMAP:   MF_01612
- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR020050
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR00423
- TIGRFAMs:   TIGR03550
- TIGRFAMs:   TIGR03551

Pfam domain/function: PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 94361; Mature: 94361

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGSYTKVSLIESQEPIALSRPVVPPKPNTSALRRVLRRARDGFALNIDEAVVAMTARGE
CCCCCEEEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCHHEEEEECCCC
DLADLCASAARVRDVGLETAGRRGADGRLPITYSRKVFIPVTHLCRDSCHYCTFVTAPDM
HHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEECCEEEEEHHHHHHCCCCEEEEECCCHH
LRTQGAGMYLEPNEILNLARRGSELGCKEALFTLGDRPEDRWAQARDWLAERGYDSTLSY
HHHCCCCEEECHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
LRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGS
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHCCC
LDKDPTVRLRVLTDAGRLSIPFTTGLLVGIGETLAERADTLHEIRKSNKEFGHVQEVIVQ
CCCCCCEEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
NFRAKEHTAMAAVPDARIEDYLATVAVARLVLGPAMRIQAPPNLVSREECLALVTAGVDD
HHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCCC
WGGVSPLTPDHVNPERPWPALHELAAVTAEAGYTLVQRLTAQPKYVQAGAAWIDPRVRGH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHCCCCCCCE
VVALADPVTGLARDVNPVGMPWQEPDDVESAGRMDINTAIDTEGRNTEARSDLDSAFGDW
EEEEECCHHHHHHCCCCCCCCCCCCCCHHHCCCEECCCEECCCCCCCHHHHHHHHHHCCH
ESIRAHVHELADCAPERIDTDVLAALRSAERDPAGCTDDEYLALATADGPALEAVTALAD
HHHHHHHHHHHHHCHHHCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHH
SLRRDVVGDDVTFVVNRNINFTNICYTGCRFCAFAQRKGDTDAYSLSREEVAERAWEAHV
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHH
QGATEVCMQGGIDPELPVTGYVDLVRAVKTRVPSMHVHAFSPMEIANGVAKSGFSIREWL
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCHHHHHH
ISLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIEIVTTAHEVGLRSSSTMMYGHV
HHHHHCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECC
DGPRHWVAHLQVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPTHRDNRAVHALA
CCHHHHHHHHHHHHHHHHHCCCCCEECCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHH
RIMLHGRISHIQTSWVKLGVERTQAMLNGGANDLGGTLMEETISRMAGSEYGSAKTVAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IAIAEGIGRTARQRTTTYALRGA
HHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MWGSYTKVSLIESQEPIALSRPVVPPKPNTSALRRVLRRARDGFALNIDEAVVAMTARGE
CCCCCEEEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCHHEEEEECCCC
DLADLCASAARVRDVGLETAGRRGADGRLPITYSRKVFIPVTHLCRDSCHYCTFVTAPDM
HHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEECCEEEEEHHHHHHCCCCEEEEECCCHH
LRTQGAGMYLEPNEILNLARRGSELGCKEALFTLGDRPEDRWAQARDWLAERGYDSTLSY
HHHCCCCEEECHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
LRAMAIRVLEETGLLPHLNPGVMSWSELSRLKPVAPSMGMMLETTSRRLFETKGLAHYGS
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHCCC
LDKDPTVRLRVLTDAGRLSIPFTTGLLVGIGETLAERADTLHEIRKSNKEFGHVQEVIVQ
CCCCCCEEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
NFRAKEHTAMAAVPDARIEDYLATVAVARLVLGPAMRIQAPPNLVSREECLALVTAGVDD
HHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCCC
WGGVSPLTPDHVNPERPWPALHELAAVTAEAGYTLVQRLTAQPKYVQAGAAWIDPRVRGH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHCCCCCCCE
VVALADPVTGLARDVNPVGMPWQEPDDVESAGRMDINTAIDTEGRNTEARSDLDSAFGDW
EEEEECCHHHHHHCCCCCCCCCCCCCCHHHCCCEECCCEECCCCCCCHHHHHHHHHHCCH
ESIRAHVHELADCAPERIDTDVLAALRSAERDPAGCTDDEYLALATADGPALEAVTALAD
HHHHHHHHHHHHHCHHHCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHH
SLRRDVVGDDVTFVVNRNINFTNICYTGCRFCAFAQRKGDTDAYSLSREEVAERAWEAHV
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHH
QGATEVCMQGGIDPELPVTGYVDLVRAVKTRVPSMHVHAFSPMEIANGVAKSGFSIREWL
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCHHHHHH
ISLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSMWIEIVTTAHEVGLRSSSTMMYGHV
HHHHHCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECC
DGPRHWVAHLQVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPTHRDNRAVHALA
CCHHHHHHHHHHHHHHHHHCCCCCEECCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHH
RIMLHGRISHIQTSWVKLGVERTQAMLNGGANDLGGTLMEETISRMAGSEYGSAKTVAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IAIAEGIGRTARQRTTTYALRGA
HHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002