Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 221230142

GI number: 221230142

Start: 1543287

End: 1544360

Strand: Reverse

Name: pyrD [H]

Synonym: MLBr_01293

Alternate gene names: 221230142

Gene position: 1544360-1543287 (Counterclockwise)

Preceding gene: 221230143

Following gene: 221230141

Centisome position: 47.26

GC content: 64.43

Gene sequence:

>1074_bases
GTGATGTACCGGGTCGTACGCCGGCTGCTGTTCCTGACCCCACCCGAGCGGATACACACACTGGTTTTTGCCATGCTGCG
TTGCGTAACCTCCATCGCTGTGCTGCGCCGGTTGCTGCGCTGGGTACTGGGACCGACGGATCCGGTGCTGGCCAGCACGG
TTTTTGGGGTCCGCTTCCCCGGACCGCTGGGGCTGGCAGCGGGCTTCGACAAGGACGGCATGGGGCTGCTTGCCTGGGGT
GCATTAGGGTTCGGTTATGCTGAAGTCGGAACCGTCACCGCGTACCCACAGCCCGGCAACCCGGCCCCGCGCATGTTCCG
GCTGCCCGCCGACCGCGCTCTGCTGAACAGGATGGGGTTCAACAATAACGGCGCCGGAGCGCTGGCTATCCAGCTCGCCC
ACCACCGCCCCGAAGTGCCTATCGGGGTGAACATCAGCAAGACTAAGGCAACCCCGGCCTCCCATACTGTCGATGACTAC
CGGGCCAGCGCCCGGCTGGTCGGCCCGCTGGCCTCGTATCTGGTTGTCAATGTCAGCTCCCCGAATACCCCGGGGCTTCG
CGACCTACAAGCAGTCGAGTCGCTTCGGGCCATCTTGTTGGGAGTCCTGGCTGAGACCTCAGTACCAGTGCTGGTCAAGA
TTGCACCCGATATCTCCGATTCCGAGATCGACGACATCACAGACCTAGCCGTCGAACTTAGGCTAGCAGGCATCGTGGCA
ACCAACACCACAGTATCGCGTGACTGCTTGGTGACACCGGGAATCGATGCGCTGGGGGCAGGTGGCATCTCGGGGCCGCC
GGTGGCGCGCCGCGCTGTCGAGGTGTTGCGCCGGCTCTACGGACGGGTCGGTGACCGTCTGGTGCTCATCAGCGTGGGAG
GCATCGAAACTGCCGACGACGCATGGGATCGCATCACAGCGGGCGCCTCGCTGCTCCAGGGCTATACCGGATTCATCTAC
GGCGGGGGATTCTGGCCCAAACACATTCACGACGGCATCGCACGCCGGCTTCATGACGGCGGGTTCGCCTCACTGCGCGA
CGCGGTCGGGTCGGCGACCGCCAAATCGGAGTGA

Upstream 100 bases:

>100_bases
TGCGGATCTACACCGACGGCAGTAGGAGGACATTGTTGCGCCGCAATAACTCTCGTCTAGAAAACACAGGCTCCGACCGG
TGACCTGGCTAGCCGGAACT

Downstream 100 bases:

>100_bases
CCGCCAGGATAGATAATGCCACCGTATCCTGGTCATCTGTAGCTTCGTCGCATAGCAGCTTCTCGGGGCGATGAAATCCG
CAGGACAAAGTCAGCTTGTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGPTDPVLASTVFGVRFPGPLGLAAGFDKDGMGLLAWG
ALGFGYAEVGTVTAYPQPGNPAPRMFRLPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDY
RASARLVGPLASYLVVNVSSPNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDDITDLAVELRLAGIVA
TNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIY
GGGFWPKHIHDGIARRLHDGGFASLRDAVGSATAKSE

Sequences:

>Translated_357_residues
MMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGPTDPVLASTVFGVRFPGPLGLAAGFDKDGMGLLAWG
ALGFGYAEVGTVTAYPQPGNPAPRMFRLPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDY
RASARLVGPLASYLVVNVSSPNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDDITDLAVELRLAGIVA
TNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIY
GGGFWPKHIHDGIARRLHDGGFASLRDAVGSATAKSE
>Mature_357_residues
MMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGPTDPVLASTVFGVRFPGPLGLAAGFDKDGMGLLAWG
ALGFGYAEVGTVTAYPQPGNPAPRMFRLPADRALLNRMGFNNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDY
RASARLVGPLASYLVVNVSSPNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDDITDLAVELRLAGIVA
TNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADDAWDRITAGASLLQGYTGFIY
GGGFWPKHIHDGIARRLHDGGFASLRDAVGSATAKSE

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=322, Percent_Identity=39.4409937888199, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1787177, Length=331, Percent_Identity=42.5981873111783, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=38.006230529595, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI281361352, Length=363, Percent_Identity=36.6391184573003, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137316, Length=363, Percent_Identity=36.6391184573003, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37880; Mature: 37880

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGPTDPVLASTVFGVRFP
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEECC
GPLGLAAGFDKDGMGLLAWGALGFGYAEVGTVTAYPQPGNPAPRMFRLPADRALLNRMGF
CCCCCCCCCCCCCCCEEEHHHHHCCHHHHCEEEECCCCCCCCCCEEECCHHHHHHHHCCC
NNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDYRASARLVGPLASYLVVNVSS
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCC
PNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDDITDLAVELRLAGIVA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEE
TNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADD
ECCCCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHH
AWDRITAGASLLQGYTGFIYGGGFWPKHIHDGIARRLHDGGFASLRDAVGSATAKSE
HHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMYRVVRRLLFLTPPERIHTLVFAMLRCVTSIAVLRRLLRWVLGPTDPVLASTVFGVRFP
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEECC
GPLGLAAGFDKDGMGLLAWGALGFGYAEVGTVTAYPQPGNPAPRMFRLPADRALLNRMGF
CCCCCCCCCCCCCCCEEEHHHHHCCHHHHCEEEECCCCCCCCCCEEECCHHHHHHHHCCC
NNNGAGALAIQLAHHRPEVPIGVNISKTKATPASHTVDDYRASARLVGPLASYLVVNVSS
CCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCC
PNTPGLRDLQAVESLRAILLGVLAETSVPVLVKIAPDISDSEIDDITDLAVELRLAGIVA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEE
TNTTVSRDCLVTPGIDALGAGGISGPPVARRAVEVLRRLYGRVGDRLVLISVGGIETADD
ECCCCCCCEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHH
AWDRITAGASLLQGYTGFIYGGGFWPKHIHDGIARRLHDGGFASLRDAVGSATAKSE
HHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]