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The map label for this gene is pepR [C]

Identifier: 221229858

GI number: 221229858

Start: 1016292

End: 1017566

Strand: Direct

Name: pepR [C]

Synonym: MLBr_00855

Alternate gene names: 221229858

Gene position: 1016292-1017566 (Clockwise)

Preceding gene: 221229857

Following gene: 221229864

Centisome position: 31.1

GC content: 59.76

Gene sequence:

>1275_bases
GTGTGTCGCACCACACTGCCAGGCGGTCTTCGTGTGGTCACCGAACACTTACCCGCGGTGCGCTCGGCGTCTGTCGGGGT
CTGGGTGGGTGTCGGATCCCGTGATGAGGGTGCCACCGTGGCCGGGGCGGCGCACTTCCTTGAGCATCTGCTGTTCAAAT
CGACATCGACACGCACGGCCATGGATATTGCGCAGGCTATAGACGCTGTCGGTGGGGAGCTGAACGCGTTCACCGCCAAG
GAGCACACCTGTTACTACGCACACGTGCTTGACAGCGACTTGGAACTGGCCGTCGACCTGGTCGCCGATGTCGTACTCAA
TGGTCGTTGCGCCGTTGACGATGTTGAGTTGGAACGTGACGTTGTGCTTGAGGAGATCGCGATGCGTGACGATGATCCCG
AGGATGCGCTGGGTGACATGTTCTTAGCGGCGTTGTTCGGTGACCACCCGGTGGGGCGTCCAGTGATCGGCACTATGGAA
TCCGTGTCGGCGATGACGCGGACCCAACTGCACTCCTTTCATGTGCGGCGTTACACACCGGAACGGATGGTCGTTGCGGT
GGCCGGAAACGTCGACCACGATGAGATGGTCGCGTTGGTGCGTGAGCATTTTGGGTCGCGTTTGATTCGCGGGCGCCAGT
CAGCACCGCCGCGCAAGAGCACTGGAAGAATCAACGGCGGCCCCGCATTGACGCTGGGCAAGCGGGACGCCGAGCAGACC
CACGTGTTGTTGGGGGTACGCACTCCTGGCCGCAGTTGGGAACATCGTTGGGCACTGTCGGTGTTGCACACTGCACTGGG
CGGAGGCCTGAGCTCTCGTCTATTCCAAGAGATTCGCGAGACCCGCGGACTGGCCTACTCAGTGTATTCCGCGCTGGACA
TCTTCGCCGATAGTGGTGCGCTGTCCGTGTATGCTGCGTGTCTTCCTGGGCGTTTCGCCGACGTAATGCAGGTAATCAGC
GAGGTGCTTGCGTCGGTGGCGGGTGATGGCATCACCGAAGCGGAGTGCCGTATTGCCAAGGGCTCTTTGCGCGGAGGGAT
CATCCTGGGATTGGAGGATTCCAATTCTTGGATGAGCCGGCTTGGTCGCAGCGAATTGAACTACGGCAAGTACCGCGGTA
TCGAGCATACCTTGCAGCAAATCGATGAGGTCACCGTCGAGCAGGTCAACGCGCTTGCTCACCAGCTGTTGAACAAGCGC
TACGGTGCCGCTGTTCTGGGTCCGTATGCGTCGAAAAAAACTCTGCCACGACAACTTCGGATAATGGTAAATTAA

Upstream 100 bases:

>100_bases
GCCAGTAGCTGACCCCGGAGCTAAGGGTAAGGGTGCCTTGCGGCGGAGCAAGCAGGGCGCCGAGGGGAAGGCGGAAAAGA
AGGCCGCACGATCGGCTGGA

Downstream 100 bases:

>100_bases
CTGGATGGTACTGGTTTTCTGAGACATCGCAGTGAGGAACATTGTGAGCGCTCCAATGTTCGGTGCCCTGGTCTCTCCAC
GTTGGCCGCGGCGGTGTCCA

Product: putative zinc protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTAMDIAQAIDAVGGELNAFTAK
EHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVELERDVVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTME
SVSAMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTGRINGGPALTLGKRDAEQT
HVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRETRGLAYSVYSALDIFADSGALSVYAACLPGRFADVMQVIS
EVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSRLGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKR
YGAAVLGPYASKKTLPRQLRIMVN

Sequences:

>Translated_424_residues
MCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTAMDIAQAIDAVGGELNAFTAK
EHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVELERDVVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTME
SVSAMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTGRINGGPALTLGKRDAEQT
HVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRETRGLAYSVYSALDIFADSGALSVYAACLPGRFADVMQVIS
EVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSRLGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKR
YGAAVLGPYASKKTLPRQLRIMVN
>Mature_424_residues
MCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTAMDIAQAIDAVGGELNAFTAK
EHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVELERDVVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTME
SVSAMTRTQLHSFHVRRYTPERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTGRINGGPALTLGKRDAEQT
HVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRETRGLAYSVYSALDIFADSGALSVYAACLPGRFADVMQVIS
EVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSRLGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKR
YGAAVLGPYASKKTLPRQLRIMVN

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=434, Percent_Identity=30.6451612903226, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI46593007, Length=429, Percent_Identity=30.5361305361305, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI24308013, Length=431, Percent_Identity=28.538283062645, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI50592988, Length=396, Percent_Identity=22.2222222222222, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1787770, Length=190, Percent_Identity=25.2631578947368, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71999683, Length=421, Percent_Identity=28.978622327791, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17553678, Length=401, Percent_Identity=29.925187032419, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17510601, Length=429, Percent_Identity=22.8438228438228, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=424, Percent_Identity=30.188679245283, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6321813, Length=419, Percent_Identity=23.6276849642005, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357875, Length=428, Percent_Identity=28.5046728971963, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24646943, Length=428, Percent_Identity=28.5046728971963, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI19921772, Length=434, Percent_Identity=26.4976958525346, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 45989; Mature: 45989

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTA
CCCCCCCCHHHHHHHHCCHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
MDIAQAIDAVGGELNAFTAKEHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVELERD
HHHHHHHHHCCCCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTMESVSAMTRTQLHSFHVRRYTP
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECC
ERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTGRINGGPALTLGKRDAEQT
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCE
HVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRETRGLAYSVYSALDIFADSGA
EEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
LSVYAACLPGRFADVMQVISEVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSR
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCEEEEEECCHHHHHH
LGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKRYGAAVLGPYASKKTLPRQLR
CCHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHE
IMVN
EECC
>Mature Secondary Structure
MCRTTLPGGLRVVTEHLPAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTA
CCCCCCCCHHHHHHHHCCHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
MDIAQAIDAVGGELNAFTAKEHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVELERD
HHHHHHHHHCCCCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
VVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTMESVSAMTRTQLHSFHVRRYTP
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECC
ERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPPRKSTGRINGGPALTLGKRDAEQT
CEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCE
HVLLGVRTPGRSWEHRWALSVLHTALGGGLSSRLFQEIRETRGLAYSVYSALDIFADSGA
EEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
LSVYAACLPGRFADVMQVISEVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSR
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCEEEEEECCHHHHHH
LGRSELNYGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKRYGAAVLGPYASKKTLPRQLR
CCHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHE
IMVN
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]