Click here to switch to the map view.

The map label for this gene is moeZ [H]

Identifier: 221229838

GI number: 221229838

Start: 965951

End: 967138

Strand: Direct

Name: moeZ [H]

Synonym: MLBr_00817

Alternate gene names: 221229838

Gene position: 965951-967138 (Clockwise)

Preceding gene: 221229837

Following gene: 221229839

Centisome position: 29.56

GC content: 59.85

Gene sequence:

>1188_bases
ATGTCGACATCCTCGACATCACTGCCGCCGCTAGTTGAGCCTGCGGGCCAGCTGAGCCGCGATGAGGTGATTCGATACAG
CCGCCATTTGATCATTCCGGACATAGGCGTCGATGGGCAGATGCGGCTCAAGAGCGCGCGGGTATTGGTCATCGGTGCGG
GCGGGCTGGGCGCGCCGGTATTGCTGTATCTGGCCGCGGCCGGCGTCGGTACGATCGGCATCATCGATTTCGACGTCGTC
GACGAGTCGAACCTGCAACGCCAGATTATTCATGGCGTAGCCGATGTTGGACGGTCCAAGGCCCAGTCAGCGCGCGACTC
GATTGTCGCAATCAACCCGCTCGTCCAGGTGCGATTGCACGAGTTCAGGCTGGAGTCGAGTAATGTGGTTAACCTGTTCA
AGCAGTACGATCTGATCGTCGATGGCACCGACAACTTCGCGACTCGGTATTTGATCAACGACGCCGCGGTGCTGGCTAAA
AAGCCGTATGTGTGGGGGTCGCTCTACCGCTTCGAAGGCCAGGTCTCAGTGTTTTGGGAGGATGCCCCCGACGGGCTGGG
CCTGAACTACCGCGATCTGTACCTGGAGCCACCGCCCCCTGGCATGGTGCCATCCTGCGCAGAAGGCGGCGTGCTGGGCA
TCGTCTGTGCCTCTATCGCGTCGGTGATGGGCACCGAGGCGATCAAACTGATCACCGGGATTGGTGCGCCGCTGCTCGGC
CGGTTGATGATCTACAACGCGTTGGAGATGAGCTACCGTAGGATCAGGATCCACAAGGACCCGTCCAGACCGAAAATCAC
GGAGCTTACAGATTATCAGCAATTTTGCGGTGTGGTGTCTGACGATGCGGCCCAGGTGGCTACCGGCTCCATCGTTACGC
CGCGGGAATTGCGCGAGTTGCTGGATTCCGGCAAGAAGCTGGCCTTGATAGATGTTCGTGAACCCGTCGAGTGGGACATC
GTGCACATCGACGGCGCTCAGCTGATCCCGCGATCGTTGATCAACTCGGGTGAGGGTCTGGCAAAGCTGCCTCAGGACCG
CATGTCGGTGCTGTATTGCAAGACGGGCGTGCGCTCGGCCGAGACGTTGGCCACTGTGAAAAAGGCTGGTTTCTCCGACG
CGGTGCACTTGCAGGGTGGAATTGTGGCATGGGCCAAGCAGGTGCAACCCGACATGGTGATCTACTAG

Upstream 100 bases:

>100_bases
ATTGAGCGTCGTTGCCGTTGATGCAGACACCTGCTGTGATGTGTTGTAGACGACATGCCTCAGAAGTTGAACTGCGACGC
TACCCTAGGAGAGATATTCG

Downstream 100 bases:

>100_bases
TACGAGATTCGATCTTGGGCTGGTGGTGACGCGCTGTGTTCGGTTTCGCCGCGCTTGCGGTCGCCACGGTCGGGCTCTAC
TAGGCTGACCCGGGTGACAG

Product: molybdopterin biosynthesis-like protein MoeZ

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSTSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLVIGAGGLGAPVLLYLAAAGVGTIGIIDFDVV
DESNLQRQIIHGVADVGRSKAQSARDSIVAINPLVQVRLHEFRLESSNVVNLFKQYDLIVDGTDNFATRYLINDAAVLAK
KPYVWGSLYRFEGQVSVFWEDAPDGLGLNYRDLYLEPPPPGMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLG
RLMIYNALEMSYRRIRIHKDPSRPKITELTDYQQFCGVVSDDAAQVATGSIVTPRELRELLDSGKKLALIDVREPVEWDI
VHIDGAQLIPRSLINSGEGLAKLPQDRMSVLYCKTGVRSAETLATVKKAGFSDAVHLQGGIVAWAKQVQPDMVIY

Sequences:

>Translated_395_residues
MSTSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLVIGAGGLGAPVLLYLAAAGVGTIGIIDFDVV
DESNLQRQIIHGVADVGRSKAQSARDSIVAINPLVQVRLHEFRLESSNVVNLFKQYDLIVDGTDNFATRYLINDAAVLAK
KPYVWGSLYRFEGQVSVFWEDAPDGLGLNYRDLYLEPPPPGMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLG
RLMIYNALEMSYRRIRIHKDPSRPKITELTDYQQFCGVVSDDAAQVATGSIVTPRELRELLDSGKKLALIDVREPVEWDI
VHIDGAQLIPRSLINSGEGLAKLPQDRMSVLYCKTGVRSAETLATVKKAGFSDAVHLQGGIVAWAKQVQPDMVIY
>Mature_394_residues
STSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLVIGAGGLGAPVLLYLAAAGVGTIGIIDFDVVD
ESNLQRQIIHGVADVGRSKAQSARDSIVAINPLVQVRLHEFRLESSNVVNLFKQYDLIVDGTDNFATRYLINDAAVLAKK
PYVWGSLYRFEGQVSVFWEDAPDGLGLNYRDLYLEPPPPGMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLGR
LMIYNALEMSYRRIRIHKDPSRPKITELTDYQQFCGVVSDDAAQVATGSIVTPRELRELLDSGKKLALIDVREPVEWDIV
HIDGAQLIPRSLINSGEGLAKLPQDRMSVLYCKTGVRSAETLATVKKAGFSDAVHLQGGIVAWAKQVQPDMVIY

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=330, Percent_Identity=41.5151515151515, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4885649, Length=132, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI38045944, Length=114, Percent_Identity=38.5964912280702, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI38045942, Length=114, Percent_Identity=38.5964912280702, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=37.8048780487805, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI87082356, Length=246, Percent_Identity=35.7723577235772, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17540406, Length=403, Percent_Identity=36.7245657568238, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI193203301, Length=137, Percent_Identity=32.1167883211679, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71984476, Length=111, Percent_Identity=38.7387387387387, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321903, Length=397, Percent_Identity=36.0201511335013, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320598, Length=140, Percent_Identity=30, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322639, Length=194, Percent_Identity=23.7113402061856, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325438, Length=139, Percent_Identity=29.4964028776978, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582879, Length=404, Percent_Identity=36.6336633663366, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24660640, Length=139, Percent_Identity=37.410071942446, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129973, Length=108, Percent_Identity=37.962962962963, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573937, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 42845; Mature: 42714

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLVIGAGGLGAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCCCCCEEEEECEEEEEECCCCHHHH
LLYLAAAGVGTIGIIDFDVVDESNLQRQIIHGVADVGRSKAQSARDSIVAINPLVQVRLH
HHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHEEH
EFRLESSNVVNLFKQYDLIVDGTDNFATRYLINDAAVLAKKPYVWGSLYRFEGQVSVFWE
HHCCCCCHHHHHHHHCCEEEECCCCCEEEEEECCHHHHHCCCCEEEEEEEECCEEEEEEE
DAPDGLGLNYRDLYLEPPPPGMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLG
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLMIYNALEMSYRRIRIHKDPSRPKITELTDYQQFCGVVSDDAAQVATGSIVTPRELREL
HHHHHHHHHHCEEEEEEECCCCCCCCCHHHCHHHHCCCCCCCHHHHHCCCCCCHHHHHHH
LDSGKKLALIDVREPVEWDIVHIDGAQLIPRSLINSGEGLAKLPQDRMSVLYCKTGVRSA
HHCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHCCCCCHHHCCHHHHEEEEECCCCCCH
ETLATVKKAGFSDAVHLQGGIVAWAKQVQPDMVIY
HHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEC
>Mature Secondary Structure 
STSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLVIGAGGLGAPV
CCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCCCCCEEEEECEEEEEECCCCHHHH
LLYLAAAGVGTIGIIDFDVVDESNLQRQIIHGVADVGRSKAQSARDSIVAINPLVQVRLH
HHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHEEH
EFRLESSNVVNLFKQYDLIVDGTDNFATRYLINDAAVLAKKPYVWGSLYRFEGQVSVFWE
HHCCCCCHHHHHHHHCCEEEECCCCCEEEEEECCHHHHHCCCCEEEEEEEECCEEEEEEE
DAPDGLGLNYRDLYLEPPPPGMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLG
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLMIYNALEMSYRRIRIHKDPSRPKITELTDYQQFCGVVSDDAAQVATGSIVTPRELREL
HHHHHHHHHHCEEEEEEECCCCCCCCCHHHCHHHHCCCCCCCHHHHHCCCCCCHHHHHHH
LDSGKKLALIDVREPVEWDIVHIDGAQLIPRSLINSGEGLAKLPQDRMSVLYCKTGVRSA
HHCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHCCCCCHHHCCHHHHEEEEECCCCCCH
ETLATVKKAGFSDAVHLQGGIVAWAKQVQPDMVIY
HHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]