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The map label for this gene is rmlD [H]

Identifier: 221229796

GI number: 221229796

Start: 893630

End: 894565

Strand: Direct

Name: rmlD [H]

Synonym: MLBr_00751

Alternate gene names: 221229796

Gene position: 893630-894565 (Clockwise)

Preceding gene: 221229792

Following gene: 221229797

Centisome position: 27.34

GC content: 64.42

Gene sequence:

>936_bases
GTGTCGGACAGGTCAGGCAGACTAGTGATTACCGGTGCCGGTGGGCAGCTTGGCAGCGCTCTAGCGGCGCAGGCCACCGC
TGCGGGCCGGGACGTGCTAGCGTTGACCTCGTCGCAATGGGATATTACCGATGCCGCGGTCGCCGAACGGATGGGGCGCA
GCGCCCTCAAAAAAAATGATGTCGTGGTGAACTGTGCGGCCTACACCAATGTAGACGGCGCCGAAAGCAACGAGTTGGCC
GCGTATGCGGTCAATGCTACCGGTCCGGAGTATATCGCGCGTGCCTGCCGGTGCGCCGGCGCTGCCCTGATTCACGTCTC
AACCGACTATGTGTTCAGTGGTGATTTCGGCTCGGGCGCTAATAGGGTTGCTCCGCGTCCGTATGAGCCTACGGATGAAA
CTGGGCCGCTGGGGGTGTACGGACGCAGCAAACTTGCTGGTGAGCAGGCCGTACTGGCAGCGATGCCCGAGGCCACCGTG
GTCCGGACCGCCTGGGTCTACACCGGCGGGACCGGCAAGGATTTCGTCGCTGTCATGCGACGCTTGGCTGCTGGGGACGG
CCCGGTGTACGTGGTTGATGATCAGATCGGCTCGCCGACCTATGTTGTCGATCTGGCTGCCGCACTGCTGCAGGTCGCCG
ACGGCAGTGTGCATGGGTCCGTCCTACACGCCGCCAACGAGGGGGAGGTTTCACGATTCGGCCAAGCCCGCGCCGTGTTC
GAAGAATGCGGCGCTGACCCGCTGCAAGTGCAACCCGTTAGCACCGCCCAAAACCCGCGTTCGGCGGCCCGGCCGGCCTA
TTCCGCGCTATCTGGTCGACAGTCCGTCGCGGCTGGCTTAACGCCGCTAAGGCCCTGGCGCAGCGCACTTGTCGAGGCAC
TCGCGGTATCTCGCAGCCTCCCGGTCGATCGACCGTTACCCTCTACGCGTGACTGA

Upstream 100 bases:

>100_bases
TTGCACAGGCATCCCACTAGGTTACTTGTGATATAGCAGCTTGCCGGGTAGCCCAGCCGTGGCGTGGCCCGAGCTTTCTA
AGGCATGCCAGACTCGAACC

Downstream 100 bases:

>100_bases
CGTGCTGCCCGTCGTCGCGGTGACTTACTCGCCGGGACCGCACTTGGAGCGTTTTCTGGCTTCGTTAGCATTGGCCACTG
ACCGCCCGGTGAGCGTGGTG

Product: putative dTDP-rhamnose modification protein

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKNDVVVNCAAYTNVDGAESNELA
AYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGANRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATV
VRTAWVYTGGTGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVLHAANEGEVSRFGQARAVF
EECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSRSLPVDRPLPSTRD

Sequences:

>Translated_311_residues
MSDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKNDVVVNCAAYTNVDGAESNELA
AYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGANRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATV
VRTAWVYTGGTGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVLHAANEGEVSRFGQARAVF
EECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSRSLPVDRPLPSTRD
>Mature_310_residues
SDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKNDVVVNCAAYTNVDGAESNELAA
YAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGANRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATVV
RTAWVYTGGTGKDFVAVMRRLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVLHAANEGEVSRFGQARAVFE
ECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSRSLPVDRPLPSTRD

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=308, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI11034825, Length=308, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1788352, Length=224, Percent_Identity=37.5, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32132; Mature: 32001

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKND
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
VVVNCAAYTNVDGAESNELAAYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGA
EEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEEEECEEEECCCCCCC
NRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATVVRTAWVYTGGTGKDFVAVMR
CCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHH
RLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVLHAANEGEVSRFGQARAVF
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHH
EECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSRSL
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHCC
PVDRPLPSTRD
CCCCCCCCCCC
>Mature Secondary Structure 
SDRSGRLVITGAGGQLGSALAAQATAAGRDVLALTSSQWDITDAAVAERMGRSALKKND
CCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
VVVNCAAYTNVDGAESNELAAYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDFGSGA
EEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEEEECEEEECCCCCCC
NRVAPRPYEPTDETGPLGVYGRSKLAGEQAVLAAMPEATVVRTAWVYTGGTGKDFVAVMR
CCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHH
RLAAGDGPVYVVDDQIGSPTYVVDLAAALLQVADGSVHGSVLHAANEGEVSRFGQARAVF
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHH
EECGADPLQVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLRPWRSALVEALAVSRSL
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHCC
PVDRPLPSTRD
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]