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The map label for this gene is purE

Identifier: 221229791

GI number: 221229791

Start: 877252

End: 877767

Strand: Direct

Name: purE

Synonym: MLBr_00736

Alternate gene names: 221229791

Gene position: 877252-877767 (Clockwise)

Preceding gene: 221229790

Following gene: 221229792

Centisome position: 26.84

GC content: 64.15

Gene sequence:

>516_bases
ATGACCAGGCAGCCCCGAGTCGGGGTGATCATGGGCAGCGACAGCGACTGGTCGGTGATGCAAGATGCGGCCCATGCACT
GGCGGAGTTTGACATCCCGATCGAGGTTCGGGTGGTGTCGGCGCATCGCACCCCTGCTGAGATGTTCGACTATGCGCGCA
ATGCTGTCGACCGCAGCATCGCGGTGATCATTGCCGGCGCCGGCGGCGCAGCTCACCTGCCTGGAATGGTCGCTTCCGCG
ACTCCGCTGCCGGTGATCGGGGTGCCGGTGCCGCTGGCCAGGCTCGACGGCCTGGACTCGCTGCTGTCGATCGTGCAGAT
GCCAGCGGGAGTTCCGGTTGCCACAGTGTCTATCGGTGGTGCCCGCAACGCGGGTTTGTTGGCGGTGCGTATTTTGGGAT
CGTCGGACCTGCAGCTTCGAGCGCAGCTGGTCGCGTTCCAGGACCGGTTGGCCGATACCGTGCGGGCCAAGGATGCGGAT
TTACAGCGGTTTCGAGGTAAGTTAATCGGCGACTAA

Upstream 100 bases:

>100_bases
GGCAGTGGACGGATGGATGGGATCCACACCGTGCCGGCGACGATGTAGTGGAGATATCTCTCGCTTGCGGAGGACGAAAC
GATGCGCAGAGGCAGCGCTG

Downstream 100 bases:

>100_bases
TGTCTGACTCTCTCCCCGCACGCGGGTGGGGATGGTCCCACCGCAGACCGCAAGTAATCCGTCCGCATCATGGTCAGGTT
AGAAGGAGGCAGTGATGGTT

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTPAEMFDYARNAVDRSIAVIIAGAGGAAHLPGMVASA
TPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDAD
LQRFRGKLIGD

Sequences:

>Translated_171_residues
MTRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTPAEMFDYARNAVDRSIAVIIAGAGGAAHLPGMVASA
TPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDAD
LQRFRGKLIGD
>Mature_170_residues
TRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTPAEMFDYARNAVDRSIAVIIAGAGGAAHLPGMVASAT
PLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDADL
QRFRGKLIGD

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=57.6576576576577, Blast_Score=130, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=57.2327044025157, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_MYCLE (P46702)

Other databases:

- EMBL:   U00012
- EMBL:   AL583919
- PIR:   A87001
- RefSeq:   NP_301576.1
- ProteinModelPortal:   P46702
- SMR:   P46702
- EnsemblBacteria:   EBMYCT00000029480
- GeneID:   909681
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0736
- NMPDR:   fig|272631.1.peg.448
- Leproma:   ML0736
- GeneTree:   EBGT00050000016911
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- ProtClustDB:   CLSK792398
- BioCyc:   MLEP272631:ML0736-MONOMER
- BRENDA:   4.1.1.21
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 17912; Mature: 17781

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: BINDING 13-13 BINDING 16-16 BINDING 43-43

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTPAEMFDYARNAVDRSI
CCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCEE
AVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGG
EEEEECCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECC
ARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDADLQRFRGKLIGD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TRQPRVGVIMGSDSDWSVMQDAAHALAEFDIPIEVRVVSAHRTPAEMFDYARNAVDRSI
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCEE
AVIIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGG
EEEEECCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECC
ARNAGLLAVRILGSSDLQLRAQLVAFQDRLADTVRAKDADLQRFRGKLIGD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002