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The map label for this gene is accD5

Identifier: 221229786

GI number: 221229786

Start: 872017

End: 873666

Strand: Reverse

Name: accD5

Synonym: MLBr_00731

Alternate gene names: 221229786

Gene position: 873666-872017 (Counterclockwise)

Preceding gene: 221229789

Following gene: 221229785

Centisome position: 26.73

GC content: 60.48

Gene sequence:

>1650_bases
ATGACAAGCGTTACCGACCACTCGGCTCATTCAATGGAACGCGCTGCCGAGCACACGATCAATATCCACACCACGGCAGG
CAAGCTGGCCGAGCTGCATAAGCGGACCGAAGAAGCGCTGCATCCGGTCGGTGCAGCTGCCTTCGAGAAGGTACACGCTA
AGGGTAAGTTTACCGCCCGCGAGCGCATCTACGCCCTATTGGACGACGACTCATTCGTCGAACTCGACGCACTGGCCAGA
CACCGCAGCACCAACTTCGGCCTCGGTGAAAACCGCCCGGTAGGCGATGGCGTGGTCACCGGCTACGGCACCATCGACGG
CCGCGACGTATGCATCTTCAGCCAGGACGTCACGGTGTTCGGCGGCAGCCTGGGCGAAGTGTATGGCGAGAAGATCGTCA
AGGTCCAGGAACTGGCGATCAAGACCGGCCGTCCGCTTATCGGCATCAACGACGGCGCGGGCGCGCGTATCCAAGAAGGC
GTCGTCTCGCTCGGCCTGTACAGCCGGATTTTCCGCAACAATATCTTGGCCTCCGGCGTCATCCCGCAGATCTCGCTGAT
CATGGGAGCGGCCGCCGGTGGACACGTGTATTCCCCAGCACTGACCGACTTCGTGGTTATGGTCGACCAAACCAGCCAGA
TGTTCATCACCGGACCCGACGTCATCAAGACCGTCACCGGCGAGGACGTCACCATGGAGGAGCTGGGTGGCGCCCATACC
CACATGGCCAAGTCGGGTACCGCACACTATGTAGCATCGGGCGAGCAAGACGCCTTCGATTGGGTGCGCGATGTGTTGAG
CTACCTGCCGTCAAACAACTTCACCGACGCGCCGCGGTATTCTAAGCCCGTTCCTCACGGCTCCATTGAAGACAACCTGA
CCGCTAAAGACTTGGAGTTGGACACGCTTATCCCGGACTCGCCGAACCAACCGTACGACATGCACGAAGTGGTGACCCGC
CTCCTCGACGAGGAAGAGTTCCTTGAGGTGCAAGCCGGTTACGCCACCAACATCGTCGTCGGGCTCGGACGCATAGATGA
CCGACCGGTGGGCATCGTTGCCAACCAACCCATCCAGTTCGCCGGCTGTCTAGACATCAACGCCTCGGAAAAGGCAGCCC
GATTTGTGCGGGTCTGCGACTGCTTCAACATCCCGATCGTGATGTTGGTGGATGTTCCAGGCTTCCTGCCTGGCACCGAG
CAAGAATATGATGGCATCATCCGACGCGGCGCAAAGCTGCTCTTCGCCTACGGCGAAGCCACCGTACCCAAGATCACCGT
CATCACCCGCAAGGCCTACGGTGGCGCTTACTGCGTGATGGGCTCCAAAAATATGGGCTGCGACGTCAACCTGGCTTGGC
CGACCGCACAGATTGCGGTGATGGGTGCCTCCGGCGCAGTAGGCTTCGTGTACCGCAAGGAACTGGCCCAAGCGGCCAAG
AACGGCGCCAATGTTGATGAGCTACGCCTGCAGCTGCAGCAAGAGTACGAGGACACCCTGGTGAACCCGTACATCGCCGC
CGAACGAGGTTACGTCGATGCGGTGATCCCGCCGTCACACACTCGCGGCTACATTGCCACGGCGCTTCACCTGTTGGAGC
GCAAGATCGCACACCTTCCCCCCAAGAAGCACGGGAACATTCCGCTGTGA

Upstream 100 bases:

>100_bases
GCTGGATCCAGCGGCGGCTTGAGTAGATCACTACCCAACTCATCTCCTCGCAAACCCAGCGTAACCACCACCACAGCAGC
TGCCGATAACATCGACTCCC

Downstream 100 bases:

>100_bases
GTGCAGCGAACGACGGGAGTGAGACGAACAAATTGCCCACGACCCAAAACCCACATATTCAAATAACCAAAGGACAACCC
ACCGATCAGGAGTTGGCCGC

Product: acetyl/propionyl CoA carboxylase beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEKVHAKGKFTARERIYALLDDDSFVELDALAR
HRSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEG
VVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHT
HMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTR
LLDEEEFLEVQAGYATNIVVGLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTE
QEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAK
NGANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPKKHGNIPL

Sequences:

>Translated_549_residues
MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEKVHAKGKFTARERIYALLDDDSFVELDALAR
HRSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEG
VVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHT
HMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTR
LLDEEEFLEVQAGYATNIVVGLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTE
QEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAK
NGANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPKKHGNIPL
>Mature_548_residues
TSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEKVHAKGKFTARERIYALLDDDSFVELDALARH
RSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGV
VSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTH
MAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLELDTLIPDSPNQPYDMHEVVTRL
LDEEEFLEVQAGYATNIVVGLGRIDDRPVGIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTEQ
EYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAKN
GANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain

Homologues:

Organism=Homo sapiens, GI119943100, Length=544, Percent_Identity=51.8382352941177, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI295821216, Length=564, Percent_Identity=50, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=31.6091954022989, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25147362, Length=537, Percent_Identity=51.9553072625698, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI25147359, Length=532, Percent_Identity=52.8195488721805, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17552936, Length=561, Percent_Identity=29.7682709447415, Blast_Score=228, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=379, Percent_Identity=24.0105540897098, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586065, Length=536, Percent_Identity=31.1567164179104, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCCB_MYCLE (P53002)

Other databases:

- EMBL:   U00012
- EMBL:   AL583919
- PIR:   D87000
- RefSeq:   NP_301571.1
- ProteinModelPortal:   P53002
- SMR:   P53002
- EnsemblBacteria:   EBMYCT00000028385
- GeneID:   909674
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0731
- NMPDR:   fig|272631.1.peg.443
- Leproma:   ML0731
- GeneTree:   EBGT00050000015716
- HOGENOM:   HBG461319
- OMA:   WRKHGNI
- ProtClustDB:   CLSK792402
- BioCyc:   MLEP272631:ML0731-MONOMER
- BRENDA:   6.4.1.3
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762

Pfam domain/function: PF01039 Carboxyl_trans

EC number: =6.4.1.3

Molecular weight: Translated: 59397; Mature: 59266

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50989 COA_CT_CTER; PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEKVHAKGKFTAR
CCCCCCCHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEHH
ERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVF
HEEEEEECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEE
GGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGV
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHCCC
IPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHT
HHHHHHHHCCCCCCCEECCHHHEEEEEEECCCEEEEECCHHHEECCCCCEEHHHHCCCHH
HMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLEL
HHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
DTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRPVGIVANQPIQF
EEECCCCCCCCCCHHHHHHHHHCCHHHHEEECCCEEEEEEEECCCCCCCEEEEECCCEEE
AGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTEQEYDGIIRRGAKLLFAYGEA
EEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCC
TVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAK
CCCEEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHH
NGANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLP
CCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
PKKHGNIPL
CCCCCCCCC
>Mature Secondary Structure 
TSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEKVHAKGKFTAR
CCCCCCHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEHH
ERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVTGYGTIDGRDVCIFSQDVTVF
HEEEEEECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEE
GGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGV
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHCCC
IPQISLIMGAAAGGHVYSPALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHT
HHHHHHHHCCCCCCCEECCHHHEEEEEEECCCEEEEECCHHHEECCCCCEEHHHHCCCHH
HMAKSGTAHYVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLEL
HHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
DTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRPVGIVANQPIQF
EEECCCCCCCCCCHHHHHHHHHCCHHHHEEECCCEEEEEEEECCCCCCCEEEEECCCEEE
AGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTEQEYDGIIRRGAKLLFAYGEA
EEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCC
TVPKITVITRKAYGGAYCVMGSKNMGCDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAK
CCCEEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHH
NGANVDELRLQLQQEYEDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLP
CCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
PKKHGNIPL
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002