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The map label for this gene is bccA

Identifier: 221229782

GI number: 221229782

Start: 867705

End: 869501

Strand: Reverse

Name: bccA

Synonym: MLBr_00726

Alternate gene names: 221229782

Gene position: 869501-867705 (Counterclockwise)

Preceding gene: 221229783

Following gene: 221229781

Centisome position: 26.61

GC content: 62.83

Gene sequence:

>1797_bases
GTGGCCAGTCACGCCAGCTCGAGGATCGCCAAGGTTCTCGTCGCCAACCGCGGCGAAATTGCTGTCCGGGTGATCCGCGC
GGCCCGCGATGCGAGACTGCCTAGCGTGGCAGTATACGCCGAGCCTGACGCCGAGGCGCCACATGTGCGGCTGGCCGACG
AAGCGTTCGCGCTGGGAGGTCACACTTCCGCAGAGTCCTACTTGGACTTCGGTAAGATCCTCGACGCCGCTGCAAAATCC
GGAGCCAACGCGATCCATCCCGGTTACGGGTTCCTTGCCGAGAATGCTGACTTCGCCCAGGCCGTCATCGACGCCGGCCT
GATCTGGATCGGGCCCAGCCCACAATCGATCCGCGACCTCGGCGACAAGGTCACCGCCCGCCATATCGCCGCCCGCGCAC
AGGCTCCCCTAGTGCCCGGCACCCCGGATCCGGTCAAAAACGCCGACGAGGTGGTGGCCTTCGCCAAAGAACACGGGGTA
CCGATCGCGATCAAGGCCGCCTTCGGTGGCGGCGGCAAGGGCATGAAAGTGGCCCGCACCCTCGAGGAGATTTCCGAACT
ATACGAATCGGCGGTGCGTGAGGCCACCGTTGCGTTCGGCCGCGGGGAATGTTTTGTTGAGCGCTACCTAGATAAGCCCC
GACACGTCGAAGCGCAGGTAATCGCCGATCAGCACGGCAACATTGTCGTCGCCGGTACTCGGGACTGCTCGCTACAGCGG
CGTTTCCAGAAGCTGGTCGAGGAGGCGCCGGCGCCGTTCCTAACAGACGCCCAGCGTAAGGAAATCCACGAATCCGCGAA
GCGAATCTGCAAGGAGGCCCACTACTACGGCGCTGGGACGGTAGAATATCTTGTCGGCCAGGATGGCCTAATCTCGTTCC
TGGAAGTCAACACCCGCCTTCAAGTTGAGCACCCGGTCACCGAAGAGACCACAGGCATTGATCTGGTGCTGCAGCAGTTC
AAGATCGCCAACGGCGAAAAGCTCGAACTGATCAAGGATCCTATCCCGTGCGGTCACGCCATCGAGTTCCGAATCAATGG
CGAGGACGCAGGACGCAACTTTCTGCCCTCGCCGGGGCCTGTTAGCAAGTTCCACCCGCCCACCGGTCCCGGCGTGCGAT
TGGACTCCGGGGTAGAGACCGGTTCGGTAATCGGTGGCCAGTTCGACTCCATGCTTGCCAAGCTGATCGTGCACGGCGCC
ACTCGCCAGGAAGCACTGGCGCGCGCCCGCCGCGCACTGGACGAATTCGAGGTCGAAGGCCTGGCCACGGTCATCCCGTT
CCACCGCGCTGTGGTATCCGACCCGGCGCTGATCGGCGACAACAACAGCTTCTCGGTGCACACCCGCTGGATCGAAACCG
AGTGGAATAACACCATCGAACCCTTCATCGACAACCAGCCCCTCGACGAAGAGGACACCAGGCCACAACAGACGGTGATC
GTCGAGGTCGACGGCCGCCGACTCGAGGTCTCGCTGCCCGCCGATCTCGCATTAGCTAACCCGGCCGGCTGCAATCCAGC
CGGTGTTATCCGCAAAAAACCCAAGCCGCGCAAGCGCGGTGGACACACCGGCGCAGCGACCTCCGGTGACGCGGTGACCG
CGCCCATGCAGGGCACCGTAGTCAAGGTCGCCGTTGCGGAGGGACAAACAGTGATGACAGGCGACCTAGTGGTGGTCCTC
GAGGCTATGAAGATGGAGAACCCAGTCACCGCACATAAAGATGGTATCATAACGGGCTTGGCGGTCGAAGCCGGCACGGC
CATCACTCAAGGCACGGTGCTCGCCGAGATCAAGTAA

Upstream 100 bases:

>100_bases
TACCCCCACCACCACCTGGTCGCGTCGCCGACACGACGCTTAGACTTCCCGCGACATAATTGTAAAAAATCCCTTAAAAT
ACCGCCAAACAGGAGGCGCA

Downstream 100 bases:

>100_bases
GGCTGGCCTACTCTAGCTGGTCCCACAGCCGCGCTAGCGATGTAGCCAACAGCCAATGTCACATCGATTTGTAAAATTCC
TACCCTCTCAGCAATCTGCG

Product: acetyl/propionyl CoA carboxylase alpha subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVRLADEAFALGGHTSAESYLDFGKILDAAAKS
GANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGV
PIAIKAAFGGGGKGMKVARTLEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQR
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETTGIDLVLQQF
KIANGEKLELIKDPIPCGHAIEFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHGA
TRQEALARARRALDEFEVEGLATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNTIEPFIDNQPLDEEDTRPQQTVI
VEVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPRKRGGHTGAATSGDAVTAPMQGTVVKVAVAEGQTVMTGDLVVVL
EAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK

Sequences:

>Translated_598_residues
MASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVRLADEAFALGGHTSAESYLDFGKILDAAAKS
GANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGV
PIAIKAAFGGGGKGMKVARTLEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQR
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETTGIDLVLQQF
KIANGEKLELIKDPIPCGHAIEFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHGA
TRQEALARARRALDEFEVEGLATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNTIEPFIDNQPLDEEDTRPQQTVI
VEVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPRKRGGHTGAATSGDAVTAPMQGTVVKVAVAEGQTVMTGDLVVVL
EAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK
>Mature_597_residues
ASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVRLADEAFALGGHTSAESYLDFGKILDAAAKSG
ANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGVP
IAIKAAFGGGGKGMKVARTLEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQRR
FQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETTGIDLVLQQFK
IANGEKLELIKDPIPCGHAIEFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHGAT
RQEALARARRALDEFEVEGLATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNTIEPFIDNQPLDEEDTRPQQTVIV
EVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPRKRGGHTGAATSGDAVTAPMQGTVVKVAVAEGQTVMTGDLVVVLE
AMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=45.3932584269663, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI189095269, Length=665, Percent_Identity=35.7894736842105, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI65506442, Length=665, Percent_Identity=35.7894736842105, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI295821183, Length=637, Percent_Identity=36.5777080062794, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=44.6666666666667, Blast_Score=352, Evalue=8e-97,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=44.6666666666667, Blast_Score=352, Evalue=8e-97,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=44.6666666666667, Blast_Score=352, Evalue=8e-97,
Organism=Homo sapiens, GI38679960, Length=475, Percent_Identity=31.5789473684211, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI38679977, Length=475, Percent_Identity=31.5789473684211, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI38679967, Length=475, Percent_Identity=31.5789473684211, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI38679974, Length=475, Percent_Identity=31.5789473684211, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI38679971, Length=475, Percent_Identity=31.5789473684211, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI134142062, Length=476, Percent_Identity=31.3025210084034, Blast_Score=203, Evalue=3e-52,
Organism=Escherichia coli, GI1789654, Length=426, Percent_Identity=45.0704225352113, Blast_Score=348, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=46.2053571428571, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=44.2696629213483, Blast_Score=346, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17567343, Length=430, Percent_Identity=42.5581395348837, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=27.9352226720648, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=29.5719844357977, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=29.4346978557505, Blast_Score=190, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=436, Percent_Identity=44.954128440367, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=436, Percent_Identity=45.1834862385321, Blast_Score=352, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6319685, Length=424, Percent_Identity=41.2735849056604, Blast_Score=323, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6323863, Length=443, Percent_Identity=30.4740406320542, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=480, Percent_Identity=30.8333333333333, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24652212, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=436, Percent_Identity=46.1009174311927, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651757, Length=458, Percent_Identity=43.2314410480349, Blast_Score=354, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24651759, Length=419, Percent_Identity=42.4821002386635, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=29.6, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=29.6, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=29.6, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=29.6, Blast_Score=200, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCCA_MYCLE (P46392)

Other databases:

- EMBL:   X63470
- EMBL:   U00012
- EMBL:   AL583919
- PIR:   A55579
- PIR:   G86999
- RefSeq:   NP_301567.1
- ProteinModelPortal:   P46392
- EnsemblBacteria:   EBMYCT00000029281
- GeneID:   909662
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0726
- NMPDR:   fig|272631.1.peg.439
- Leproma:   ML0726
- GeneTree:   EBGT00050000015717
- HOGENOM:   HBG535236
- OMA:   REMFRIA
- ProtClustDB:   CLSK2460473
- BioCyc:   MLEP272631:ML0726-MONOMER
- BRENDA:   6.3.4.14
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- SMART:   SM00878

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; SSF51230 Hybrid_motif; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.14

Molecular weight: Translated: 63864; Mature: 63733

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50975 ATP_GRASP; PS50979 BC; PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL; PS00866 CPSASE_1; PS00867 CPSASE_2

Important sites: ACT_SITE 299-299 BINDING 123-123 BINDING 207-207 BINDING 242-242

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVRLADEAFALGG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHEECCC
HTSAESYLDFGKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCCHHHHHH
GDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGVPIAIKAAFGGGGKGMKVART
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
LEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHH
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEETTGIDLVLQQFKIANGEKLELIKDPIPCGHAIEFRINGEDAGRNFLPSPGP
EECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCC
VSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHGATRQEALARARRALDEFEVEG
CCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
LATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNTIEPFIDNQPLDEEDTRPQQTVI
HHHHHHHHHHHHCCCCEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
VEVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPRKRGGHTGAATSGDAVTAPMQGTV
EEECCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCE
VKVAVAEGQTVMTGDLVVVLEAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK
EEEEEECCCEEEECCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEECCEEEEEEC
>Mature Secondary Structure 
ASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVRLADEAFALGG
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHEECCC
HTSAESYLDFGKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCCHHHHHH
GDKVTARHIAARAQAPLVPGTPDPVKNADEVVAFAKEHGVPIAIKAAFGGGGKGMKVART
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
LEEISELYESAVREATVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHH
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLEVNTRL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEETTGIDLVLQQFKIANGEKLELIKDPIPCGHAIEFRINGEDAGRNFLPSPGP
EECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCC
VSKFHPPTGPGVRLDSGVETGSVIGGQFDSMLAKLIVHGATRQEALARARRALDEFEVEG
CCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
LATVIPFHRAVVSDPALIGDNNSFSVHTRWIETEWNNTIEPFIDNQPLDEEDTRPQQTVI
HHHHHHHHHHHHCCCCEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
VEVDGRRLEVSLPADLALANPAGCNPAGVIRKKPKPRKRGGHTGAATSGDAVTAPMQGTV
EEECCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCE
VKVAVAEGQTVMTGDLVVVLEAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK
EEEEEECCCEEEECCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002