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The map label for this gene is hrcA

Identifier: 221229732

GI number: 221229732

Start: 756779

End: 757810

Strand: Direct

Name: hrcA

Synonym: MLBr_00624

Alternate gene names: 221229732

Gene position: 756779-757810 (Clockwise)

Preceding gene: 221229731

Following gene: 221229733

Centisome position: 23.16

GC content: 61.24

Gene sequence:

>1032_bases
GTGGGGAATGCCGACGAGCGTCGCTTTGAGGTGCTGCGCGCCATTGTAGCCGACTTCGTCGCCACCAAGGAACCGATCGG
ATCGAGGGCTTTGGTGGAGCGTCACAACTTAGGCGTGTCCAGCGCAACCATCCGCAACGACATGGCGGTGTTAGAGGCCG
AGGGGTACATCACTCAGCCGCATACCAGCTCCGGGCGAGTGCCCACGGAGAAGGGCTATCGCGAGTTTGTTGATCGACTC
GAAGACGTTAAGCCGCTATCAGCGGCCGAGCGGCGGGCGATCCAAAGCTTTCTGGAGTCCGGTGTCGACCTCGACGACGT
GCTACGCCGCGCTGTGCGACTATTGGCTCAGCTGACCTGTCAGGTGGCCGTGGTGCAGTACCCCACCTTGTCGACGTCGA
CCGTTCGCCATCTGGAAGTAATCGCGCTGAGCCCGGCCAGGTTGCTGATGGTGGTTATCACCGAGTCCGGTCGGGTGGAT
CAGCGCATCGCCGAACTCGGCGATGTTATCGACGATTACCAGCTCTCCCAGCTGCGTGAAATGCTCAGCCAGGCAATGGG
AGGCAAGAAACTGTCGGCGGCCTCGGCCGCGGTAGCCGACCTCGTCGGACGGTTTCGGGGTACGGGCGGGTTGGCCAATG
CCGTCGGCCGCTCGGCGAACGTATTGCTGGAATCGCTAGTCGAACACACCGAAGAACGCTTGTTGCTGGGTGGCACTGCC
AACCTGACCCGCAACTCTGCGGACTTCGGTGGTTCACTGCGATCCATCTTGGAAGCCCTCGAAGAACAGGTGGTGGTGCT
GCGACTGCTGGCCGCCCAACAGGAGGCTGGCAAGGTGACTGTGCGTATTGGTCACGAAACGGCGGCTGAGCAAATAATGG
GTACCTCGATGGTGTCCACCGCCTACGGTACCTCGGGTACCGTCTACGGCGGCATGGGTGTGTTGGGGCCTACCCGGATG
GATTATCCGGGAACTATCGCCAGTGTCGCTGCGGTTGCTTTGTATATCGGCGAAGTTTTGGGTGCTCGGTGA

Upstream 100 bases:

>100_bases
CGGCTTGGGTGGGGGTGGTACCACCGCCCGACGGCCGCTCATGGCGGCCAGCGCCATTGTGAGAACGTAAAATGAACGCG
ACTAAGGAGGTGGACTGGCG

Downstream 100 bases:

>100_bases
ACACGCACCCGCTACGGAATCTGTGGACAGCCGCTTAGAAGCGGCATAAGACGCTGCTAGGAGAGTTAGGCGTGGCACGC
GATTATTACGGGCTGCTCGG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MGNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRL
EDVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTCQVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVD
QRIAELGDVIDDYQLSQLREMLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTA
NLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVSTAYGTSGTVYGGMGVLGPTRM
DYPGTIASVAAVALYIGEVLGAR

Sequences:

>Translated_343_residues
MGNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRL
EDVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTCQVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVD
QRIAELGDVIDDYQLSQLREMLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTA
NLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVSTAYGTSGTVYGGMGVLGPTRM
DYPGTIASVAAVALYIGEVLGAR
>Mature_342_residues
GNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLE
DVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTCQVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVDQ
RIAELGDVIDDYQLSQLREMLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTAN
LTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVSTAYGTSGTVYGGMGVLGPTRMD
YPGTIASVAAVALYIGEVLGAR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_MYCLB (B8ZUS6)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503148.1
- ProteinModelPortal:   B8ZUS6
- SMR:   B8ZUS6
- EnsemblBacteria:   EBMYCT00000087524
- GeneID:   7326973
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016264
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 36648; Mature: 36517

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHCHHEEECCCCEECC
HTSSGRVPTEKGYREFVDRLEDVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTC
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVDQRIAELGDVIDDYQLSQLRE
HHHEEECCCCCHHHHHHHHHEEECHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
MLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTA
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEECCCC
NLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVST
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
AYGTSGTVYGGMGVLGPTRMDYPGTIASVAAVALYIGEVLGAR
HCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQP
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHCHHEEECCCCEECC
HTSSGRVPTEKGYREFVDRLEDVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTC
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVDQRIAELGDVIDDYQLSQLRE
HHHEEECCCCCHHHHHHHHHEEECHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
MLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTA
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHEEECCCC
NLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVST
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHH
AYGTSGTVYGGMGVLGPTRMDYPGTIASVAAVALYIGEVLGAR
HCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA