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The map label for this gene is ctaB [H]

Identifier: 221229710

GI number: 221229710

Start: 709913

End: 710878

Strand: Direct

Name: ctaB [H]

Synonym: MLBr_00584

Alternate gene names: 221229710

Gene position: 709913-710878 (Clockwise)

Preceding gene: 221229705

Following gene: 221229712

Centisome position: 21.72

GC content: 60.46

Gene sequence:

>966_bases
ATGCGGTCTACCATCGTGCGTAGTAGAAGCTGCGCGCTGCTGCGATCTCGAGGAGTTAAGTACGTGAGCGTTCGCGCGCG
CTTAGCGCGGAGCCGAGTGTTGGCATATCTGGCGTTGACCAAGCCGCGCGTCATCGAGCTGCTTTTGGTCACCGCCATAC
CAGCGATGCTGCTCGCCGACCGCGGTAGCGCTAATCCGCTGTTGATCCTCAATACGTTACTCGGCGGGATATCGGCTGCC
GCAGGTGCCAACACGTTCAACTGTGTTGCCGACGCCGATATCGACAAACTGATGAAGCGGACTTCCCGGCGGCCGCTGGC
GCGGGCCGCGGTGCCCCCCCGAAATGCCTTGGTGCTCGGGCTGGCGTTGACTGCGGGTTCATTCTTCTGGCTGTGGTGGA
CTACCAATCTGCTGTCGGGGCTGCTGGCGCTCGCCACCGTCGCGTTCTACGTATTCGTTTACACGCTGTTGCTCAAGCGC
CGGACGTCGCAAAACGTCGTGTGGGGCGGTGCGGCTGGGTGTATGCCGGTGATGATTGGTTGGTCGGCGATCACCGACAC
TATCGGCTGGCCAGCATTGGCAATGTTTGCCATCATCTTCTTCTGGACTCCGCCGCACACCTGGGCATTGGCGATGCGCT
ACAAGGACGACTACAAAGTGGCCAGCGTCCCGATGCTTCCGGCCGTGGCGACCGAGCGTCACGTCACCAAACAGATATTG
ATCTATACCTGGCTCACCGCATTGTCTACGCTGGTGTTGGCACTGGCGACGGGGTGGCTGTACATGGCGGTGGCCGTCGT
CGCCGGGGCATGGTTTTTAACGATGGCCCATCAGTTATACGTCGGGGTCTGTGCCGGTGAGCCGGTCAAGCCGCTACGGC
TGTTCCTGCAATCAAACAACTATCTGGCGGTGGTGTTTTGCGCGTTAGCGGTCGACTCGGTGCTCGCCTTGCCGACACTA
TTTTGA

Upstream 100 bases:

>100_bases
ACGGTTCGCTGTGGCGCAACTAGCCTGCGTCTGTTCGCGCCCTCTTTGCAATCTGGGAAAAATCTGCGTTGAAAGACCTG
TCGGGCTGTTGGCTACGGGC

Downstream 100 bases:

>100_bases
TTTTGATCACCTCTTTGGTGGCTCGAGCTTAAAGCAGCAACTTGACCGAGCCGACGGTCTTGCGGCCTTGCAGATCTTCG
TGGGTGCGGGTGGTTTCGGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRSTIVRSRSCALLRSRGVKYVSVRARLARSRVLAYLALTKPRVIELLLVTAIPAMLLADRGSANPLLILNTLLGGISAA
AGANTFNCVADADIDKLMKRTSRRPLARAAVPPRNALVLGLALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKR
RTSQNVVWGGAAGCMPVMIGWSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVASVPMLPAVATERHVTKQIL
IYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYVGVCAGEPVKPLRLFLQSNNYLAVVFCALAVDSVLALPTL
F

Sequences:

>Translated_321_residues
MRSTIVRSRSCALLRSRGVKYVSVRARLARSRVLAYLALTKPRVIELLLVTAIPAMLLADRGSANPLLILNTLLGGISAA
AGANTFNCVADADIDKLMKRTSRRPLARAAVPPRNALVLGLALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKR
RTSQNVVWGGAAGCMPVMIGWSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVASVPMLPAVATERHVTKQIL
IYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYVGVCAGEPVKPLRLFLQSNNYLAVVFCALAVDSVLALPTL
F
>Mature_321_residues
MRSTIVRSRSCALLRSRGVKYVSVRARLARSRVLAYLALTKPRVIELLLVTAIPAMLLADRGSANPLLILNTLLGGISAA
AGANTFNCVADADIDKLMKRTSRRPLARAAVPPRNALVLGLALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKR
RTSQNVVWGGAAGCMPVMIGWSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVASVPMLPAVATERHVTKQIL
IYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYVGVCAGEPVKPLRLFLQSNNYLAVVFCALAVDSVLALPTL
F

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=188, Percent_Identity=28.1914893617021, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786631, Length=247, Percent_Identity=34.0080971659919, Blast_Score=131, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6325085, Length=285, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 35045; Mature: 35045

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTIVRSRSCALLRSRGVKYVSVRARLARSRVLAYLALTKPRVIELLLVTAIPAMLLAD
CCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
RGSANPLLILNTLLGGISAAAGANTFNCVADADIDKLMKRTSRRPLARAAVPPRNALVLG
CCCCCCEEEHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCHHHCCCCCCCEEEE
LALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIG
EEHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
WSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVASVPMLPAVATERHVTKQIL
HHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCCCHHHHHHHHHHHHHH
IYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYVGVCAGEPVKPLRLFLQSNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCC
YLAVVFCALAVDSVLALPTLF
CHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRSTIVRSRSCALLRSRGVKYVSVRARLARSRVLAYLALTKPRVIELLLVTAIPAMLLAD
CCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
RGSANPLLILNTLLGGISAAAGANTFNCVADADIDKLMKRTSRRPLARAAVPPRNALVLG
CCCCCCEEEHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCHHHCCCCCCCEEEE
LALTAGSFFWLWWTTNLLSGLLALATVAFYVFVYTLLLKRRTSQNVVWGGAAGCMPVMIG
EEHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
WSAITDTIGWPALAMFAIIFFWTPPHTWALAMRYKDDYKVASVPMLPAVATERHVTKQIL
HHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCCCHHHHHHHHHHHHHH
IYTWLTALSTLVLALATGWLYMAVAVVAGAWFLTMAHQLYVGVCAGEPVKPLRLFLQSNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCC
YLAVVFCALAVDSVLALPTLF
CHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]