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The map label for this gene is tkt

Identifier: 221229709

GI number: 221229709

Start: 707614

End: 709713

Strand: Reverse

Name: tkt

Synonym: MLBr_00583

Alternate gene names: 221229709

Gene position: 709713-707614 (Counterclockwise)

Preceding gene: 221229711

Following gene: 221229708

Centisome position: 21.72

GC content: 60.76

Gene sequence:

>2100_bases
GTGACCACACTCGACCAGATCTCCACGCTGACCCAACCGCGCCATCCCGATGACTGGACCGAGATCGATTCGGCTGCAGT
CGACACCATCAGGGTGTTGGCTACCGACGCGGTCCAAAAAGCTGGCAACGGGCACCCGGGGACGGCGATGAGCTTGGCCC
CGCTGGCCTACACTTTGTTCCAGCGCACTCTACGCCACGACCCCAATGACACCGCATGGCTGGGTCGTGACCGATTCGTG
CTGTCGGCCGGGCATAGCAGCCTGACCTTATATATACAACTCTATCTCGGCGGCTTCGGTCTCGAACTATCTGACATCGA
ATCGCTGCGCACCTGGGGATCCACAACTCCTGGGCATCCAGAGTTCCGGCACACTAAGGGTGTTGAGATCACCACCGGCC
CACTCGGCCAGGGTCTAGCATCAGCAGTCGGGATGGCGATGGCATCACGTTACGAACGTGGCCTGTTCGACCCCGACGCT
GAACCGGGAGCCAGCCCTTTCGACCATTACATTTATGTGATCGCCTCCGACGGGGACATCGAAGAAGGGGTGACATCGGA
AGCGTCGTCCCTGGCCGCAGTCCAGCAACTCGGCAACCTCATCGTGTTCTACGACCACAACCAGATCTCGATCGAAGGCG
ACACCAAAATCACGCTGTGCGAGGACACCGCCGCACGCTACCGCGCCTACGGCTGGCACGTACAAGAGGTGGAAGGTGGC
GAGAACGTCGTCGGCATTGAGGAAGCCATCGCCAACGCGAAAGCCGCCACCGACCGGCCGTCGTTCATCTCACTGCGCAC
CATCATCGGTTATCCCGCGCCAACCTTGATAAACACCGGCAAAGCGCACGGTGCGGCCCTTGGCGAAGACGAGGTAGCGG
CCACTAAGCGAATCCTTGGGTTCGATCCCGACAAGACCTTTGCAGTCCGCGAGGACGTAATCACCCACACCCGCGGCTTG
ATAGCCCGCGGCAAAGAAGCCCACGAACGCTGGCAACTAGAATTCGAAGCGTGGGCACAGCGCGAGCCCGAACGCAAGGC
ACTGTTGGATCGGTTGCTCGCCCAGCAGCTTCCCGACGGCTGGGATGCTGACCTGCCGAACTGGGAGCCGAGGTCCAAGG
AATTGGCCACCCGCGCCGCATCTGGTGCGGTACTATCCGCGATAGGACCGAAACTCCCGGAGTTGTGGGGCGGGTCGGCC
GATCTAGCGGGCAGCAACAACACCACCATAAAAGACGTTGATTCCTTTGGGCCGCCGTCGATTTCGACCGACGAGTACAC
CGCACATTGGTATGGTCGCACCTTGCATTTCGGTGTTCGCGAACACGCGATGGGCGCCATTCTGTCCGGCATCGTGCTGC
ACGGCCCCACCCGCGCATATGGTGGTACATTTCTACAATTCTCCGACTACATGCGCCCGTCGGTGCGACTGGCGTCGTTG
ATGGATATTGACACGATCTACGTGTGGACGCACGATTCGGTCGGACTCGGCGAGGACGGCCCAACCCATCAGCCCATCGA
ACACCTCGCAGCGTTGCGTGCTATCCCTCGATTGTCGGTGGTGCGTCCCGCCGATGCCAACGAAACGGCATATGCCTGGC
GCACAATCCTGGCTCGCGGCGCCAACAGCGGTCCGGTCGGGCTAATCCTGACCCGGCAGAGTGTGCCAGTGTTGGAAGGC
ACCAACACCGAAGGCGTCGCCCGAGGCGGCTATGTGCTAGGCGATGGTGGCAGCTCTGAAGCTAAGGAGCCTGACGTCAT
TTTGATCGCCACCGGATCCGAGGTCCAACTCGCTGTCGCAGCTCAGAAGTTGTTGGCGGATAAAGACATCATTGTGCGGG
TGGTGTCGATGCCGTGTGTGGAATGGTTCGAGTCACAGCCGTACGAGTATCGCGACAGTGTGTTGCCCCCGTCAGTGTCG
GCACGGGTGGCCGTCGAGGCCGGCGTCGCGCAATGCTGGCATAAGCTGGTCGGAGACACCGGCAAGATTGTGTCCATCGA
GCACTACGGCGAATCCGCAGATTACCAGACTTTGTTCCGTGAGTACGGCTTCACGCCGGAGGCCGTGGTTGCCGCAGCGG
AACAGGTATTGGATAACTGA

Upstream 100 bases:

>100_bases
TAGGTACCTGGAAACCGGGCCCTGCAACAGGCCCGCACTTCCACACTAGGGTGAGATTAATCAGTTTGATGACCTGAACA
GCTGACCCAAGGACTGATTC

Downstream 100 bases:

>100_bases
AAAAAAGGCGATCTGTATGACCTCAAAAATTCAGAACCCCAACCTCGCCGCATTGAGCGCTGCCGGAGTGTCCGTTTGGT
TGGACGACTTGTCGCGAGAC

Product: transketolase

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MTTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGHPGTAMSLAPLAYTLFQRTLRHDPNDTAWLGRDRFV
LSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDA
EPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTAARYRAYGWHVQEVEGG
ENVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGKAHGAALGEDEVAATKRILGFDPDKTFAVREDVITHTRGL
IARGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDGWDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGSA
DLAGSNNTTIKDVDSFGPPSISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPSVRLASL
MDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVRPADANETAYAWRTILARGANSGPVGLILTRQSVPVLEG
TNTEGVARGGYVLGDGGSSEAKEPDVILIATGSEVQLAVAAQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVLPPSVS
ARVAVEAGVAQCWHKLVGDTGKIVSIEHYGESADYQTLFREYGFTPEAVVAAAEQVLDN

Sequences:

>Translated_699_residues
MTTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGHPGTAMSLAPLAYTLFQRTLRHDPNDTAWLGRDRFV
LSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDA
EPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTAARYRAYGWHVQEVEGG
ENVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGKAHGAALGEDEVAATKRILGFDPDKTFAVREDVITHTRGL
IARGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDGWDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGSA
DLAGSNNTTIKDVDSFGPPSISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPSVRLASL
MDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVRPADANETAYAWRTILARGANSGPVGLILTRQSVPVLEG
TNTEGVARGGYVLGDGGSSEAKEPDVILIATGSEVQLAVAAQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVLPPSVS
ARVAVEAGVAQCWHKLVGDTGKIVSIEHYGESADYQTLFREYGFTPEAVVAAAEQVLDN
>Mature_698_residues
TTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGHPGTAMSLAPLAYTLFQRTLRHDPNDTAWLGRDRFVL
SAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAE
PGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTAARYRAYGWHVQEVEGGE
NVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGKAHGAALGEDEVAATKRILGFDPDKTFAVREDVITHTRGLI
ARGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDGWDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGSAD
LAGSNNTTIKDVDSFGPPSISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPSVRLASLM
DIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVRPADANETAYAWRTILARGANSGPVGLILTRQSVPVLEGT
NTEGVARGGYVLGDGGSSEAKEPDVILIATGSEVQLAVAAQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVLPPSVSA
RVAVEAGVAQCWHKLVGDTGKIVSIEHYGESADYQTLFREYGFTPEAVVAAAEQVLDN

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=591, Percent_Identity=25.3807106598985, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4507521, Length=591, Percent_Identity=25.3807106598985, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI133778974, Length=596, Percent_Identity=23.1543624161074, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1788808, Length=676, Percent_Identity=44.8224852071006, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI48994911, Length=676, Percent_Identity=43.7869822485207, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17539652, Length=536, Percent_Identity=26.4925373134328, Blast_Score=129, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325331, Length=682, Percent_Identity=45.1612903225806, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319593, Length=684, Percent_Identity=42.8362573099415, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45551847, Length=601, Percent_Identity=25.1247920133111, Blast_Score=139, Evalue=9e-33,
Organism=Drosophila melanogaster, GI45550715, Length=601, Percent_Identity=25.1247920133111, Blast_Score=139, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24645119, Length=579, Percent_Identity=24.8704663212435, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24666278, Length=595, Percent_Identity=24.2016806722689, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT_MYCLE (P46708)

Other databases:

- EMBL:   U00013
- EMBL:   Z99125
- EMBL:   AL583919
- PIR:   S72772
- RefSeq:   NP_301494.1
- ProteinModelPortal:   P46708
- SMR:   P46708
- EnsemblBacteria:   EBMYCT00000029009
- GeneID:   910090
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0583
- NMPDR:   fig|272631.1.peg.366
- Leproma:   ML0583
- GeneTree:   EBGT00050000016270
- HOGENOM:   HBG565885
- OMA:   ISIEHYG
- ProtClustDB:   PRK05899
- BioCyc:   MLEP272631:ML0583-MONOMER
- BRENDA:   2.2.1.1
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 75642; Mature: 75511

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGHPGTAMSLAPLAYTLF
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QRTLRHDPNDTAWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPGHP
HHHHCCCCCCCEEECCCEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCC
EFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDI
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCC
EEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTAARYRAYGWHVQEVEGG
CCCCHHHHHHHHHHHHHCCEEEEEECCEEEECCCCEEEEECCHHHHHHHCCCEEEEECCC
ENVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGKAHGAALGEDEVAATKRILG
CCEEEHHHHHHCCCCCCCCCCEEEEHHHHCCCCCHHEECCCCCCCCCCCHHHHHHHHHHC
FDPDKTFAVREDVITHTRGLIARGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDG
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHEEEHHHHHCCCCHHHHHHHHHHHHHCCCC
WDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGSADLAGSNNTTIKDVDSFGPPS
CCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCHHHCCCCCCCCCCCCCEEEEHHCCCCCC
ISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPSVRLASL
CCCCCEEEEECCCEEECCHHHHHHHHHHHHHHCCCCCHHCCCEEEEEHHHCCCHHHHHHH
MDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVRPADANETAYAWRTILARG
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCC
ANSGPVGLILTRQSVPVLEGTNTEGVARGGYVLGDGGSSEAKEPDVILIATGSEVQLAVA
CCCCCEEEEEECCCCCEEECCCCCCEECCCEEEECCCCCCCCCCCEEEEECCCCEEHHHH
AQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVLPPSVSARVAVEAGVAQCWHKLVGDT
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCC
GKIVSIEHYGESADYQTLFREYGFTPEAVVAAAEQVLDN
CCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTLDQISTLTQPRHPDDWTEIDSAAVDTIRVLATDAVQKAGNGHPGTAMSLAPLAYTLF
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
QRTLRHDPNDTAWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSTTPGHP
HHHHCCCCCCCEEECCCEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCC
EFRHTKGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDI
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCC
EEGVTSEASSLAAVQQLGNLIVFYDHNQISIEGDTKITLCEDTAARYRAYGWHVQEVEGG
CCCCHHHHHHHHHHHHHCCEEEEEECCEEEECCCCEEEEECCHHHHHHHCCCEEEEECCC
ENVVGIEEAIANAKAATDRPSFISLRTIIGYPAPTLINTGKAHGAALGEDEVAATKRILG
CCEEEHHHHHHCCCCCCCCCCEEEEHHHHCCCCCHHEECCCCCCCCCCCHHHHHHHHHHC
FDPDKTFAVREDVITHTRGLIARGKEAHERWQLEFEAWAQREPERKALLDRLLAQQLPDG
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHEEEHHHHHCCCCHHHHHHHHHHHHHCCCC
WDADLPNWEPRSKELATRAASGAVLSAIGPKLPELWGGSADLAGSNNTTIKDVDSFGPPS
CCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCHHHCCCCCCCCCCCCCEEEEHHCCCCCC
ISTDEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPSVRLASL
CCCCCEEEEECCCEEECCHHHHHHHHHHHHHHCCCCCHHCCCEEEEEHHHCCCHHHHHHH
MDIDTIYVWTHDSVGLGEDGPTHQPIEHLAALRAIPRLSVVRPADANETAYAWRTILARG
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCC
ANSGPVGLILTRQSVPVLEGTNTEGVARGGYVLGDGGSSEAKEPDVILIATGSEVQLAVA
CCCCCEEEEEECCCCCEEECCCCCCEECCCEEEECCCCCCCCCCCEEEEECCCCEEHHHH
AQKLLADKDIIVRVVSMPCVEWFESQPYEYRDSVLPPSVSARVAVEAGVAQCWHKLVGDT
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCC
GKIVSIEHYGESADYQTLFREYGFTPEAVVAAAEQVLDN
CCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002