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The map label for this gene is PPE [H]

Identifier: 221229673

GI number: 221229673

Start: 654443

End: 656059

Strand: Direct

Name: PPE [H]

Synonym: MLBr_00539

Alternate gene names: 221229673

Gene position: 654443-656059 (Clockwise)

Preceding gene: 221229672

Following gene: 221229674

Centisome position: 20.03

GC content: 61.84

Gene sequence:

>1617_bases
ATGACGAACCCATGGATGGCTTTCCCCCCCGAGGTACAGTCGGCGATGCTGAACTTCGGTGCAGGGGTCGGACCCATGTT
GAACTCCGCCTCGTACAACTTATGGCTCAGCGCCGAGTACCGCTGGGTTGCATCAGAGGTCGAGGCATTGCTAAGGGAAG
TGCGGTCCGGGGGGTGGCAGGGGCAAGCCGTCGAGATGTTTGTGGGCTCGTGTATGCCATTTCTGGCATGGCTGATGAAA
GCCGCCGCCGACTACATGGACGTGGCCACTCAACAAGAGGTCGTGGCCGCGGCTTACGCCGCCGCAGTAGAGGCCATGCC
GACACAATTCGAGCTGGCCGCCAACCGAGTCGTGCGTGGGGTGTTGATGGCGACCAATTTCTTTGGTGTCAACACTATCC
CCATTGCGCTCAACGAGGAAGAGTATGTGCAGATGTGGGTTCGGGCCGCCACTACGATGGCGACCTATTCGGCAATCTCT
CAGTCGGCATTAGCCGCGACGCCGCAGGCCACTCCCCCGCCGCTGATCCTGAAATCCAATGTGCTAGTCGATGACGTTGA
GAAGGACTCTCGTCATGACGGTCACAGCCATGGCGGTCACGCCAGCGCGATGGATAGGGTGTTTGCAGACATCCTGCGTA
ACGTCAGCGGAGGCCGCCTAGTTTGGGACCCTCTCAATGGCACCTTGAACGGACTGGACTACGACGACTATGTCTACCCG
GGTCAGCCGATCTGGTGGCTTGCTCGAGGCCTTGAGTTTTTTCAGGATGGTGAACAGTTTTGGGAACTGTTGTTTATCAA
TCCGACAGCGGCTTTTCAGTTCCTCCTTTACATCGTTGTGTTGGATTTGCCGACGCACATAGTCCAACTTGGTACCTGGC
TGGCCGAGTATCCGCAGTTGCTGTTGGTTGCTCTCGGTGGTACCATCGCCAACCTGGGAGCGGTAACCGGCTTGGCGGGG
CTATCATCTGGCCTGAGTGCCGGTCCGTCTGCTGCGATACCCACCGTTGTACCGGAGTCGGCACCCATCGCGACTGTGCC
CGCTATGTTGGCGGGTGCCGGGGTGGCCCCGGCAGTCGTTGCTCCAGGTGCGTCGCCCTCCTCAGCCGCCCCACCAGCGT
CGGCGGCCAGCGCCGCCGCGGCCGCCCCGGCGCCGCCGGGTACTGGTTTCGGGGGTTTTTCTCCTTACCTCGTCGACGGT
CGCGGTCCAGGCGTTGGGTTCGGCTCCGGACGACAGTCGGCTTACGCCAACAAGGTCTCGGAGTCGGTCTCCGATTCCGC
TGTGGCTGAGGCGGCTGCCCAGGCCTCGGCGCGTGAGCAGGCGAGGGCTTGGCGGCGGCGCTCGGCGGCGAAAGAACGTG
GCTATCGTGAAGAGGTCATTACGATGAACACGGGTTTCGACGCGGCAATTCCGTCGCCAGTTGACCAGACAGGTTCCCGG
GTGTCCGATTGTGGCGCGGGATCCTTCGGGTTTGCTGGAACGGTAAGCAAGGAGGCCGTTGTCGAAGTGGCCGGGTTGAC
TACGCTGGCTGGTGATGATTTCGGTGGCGGCCCAACGATGCCGATGGTACCGGGTACCTGGGCCCCGGCCAGGGAGTCAA
GCGACGAGGGACGGTGA

Upstream 100 bases:

>100_bases
CGGAGGAGCTTGGCCGCTGGGGCGTCGGAGTGGCCGAATCGGGTGTTAGTTATGCGCTTCGGGATGCGTTCGCGGTAGCA
TCGTACCTTGGCGGTGGGCT

Downstream 100 bases:

>100_bases
TACGACGTCAAGGGGACTGCGAAGCGCAGCGAAGCCCTGAAGCTGAGTTCGCAAGCAAATTTTTTGACGGGTCGCTTGAT
GCCTATATTGCTTAACCGGT

Product: PPE-family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMK
AAADYMDVATQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNEEEYVQMWVRAATTMATYSAIS
QSALAATPQATPPPLILKSNVLVDDVEKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVYP
GQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQLGTWLAEYPQLLLVALGGTIANLGAVTGLAG
LSSGLSAGPSAAIPTVVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDG
RGPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSR
VSDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGGPTMPMVPGTWAPARESSDEGR

Sequences:

>Translated_538_residues
MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMK
AAADYMDVATQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNEEEYVQMWVRAATTMATYSAIS
QSALAATPQATPPPLILKSNVLVDDVEKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVYP
GQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQLGTWLAEYPQLLLVALGGTIANLGAVTGLAG
LSSGLSAGPSAAIPTVVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDG
RGPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSR
VSDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGGPTMPMVPGTWAPARESSDEGR
>Mature_537_residues
TNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKA
AADYMDVATQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNEEEYVQMWVRAATTMATYSAISQ
SALAATPQATPPPLILKSNVLVDDVEKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVYPG
QPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQLGTWLAEYPQLLLVALGGTIANLGAVTGLAGL
SSGLSAGPSAAIPTVVPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDGR
GPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSRV
SDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGGPTMPMVPGTWAPARESSDEGR

Specific function: Unknown

COG id: COG5651

COG function: function code N; PPE-repeat proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000030 [H]

Pfam domain/function: PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 56127; Mature: 55996

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVASEVEALLREVRSGGWQ
CCCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCC
GQAVEMFVGSCMPFLAWLMKAAADYMDVATQQEVVAAAYAAAVEAMPTQFELAANRVVRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VLMATNFFGVNTIPIALNEEEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSN
HHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
VLVDDVEKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVYP
CEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
GQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQLGTWLAEYPQL
CCHHHHHHHHHHHHHCHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVVPESAPIATVPAMLAGAGVAPAVV
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEE
APGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVS
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHH
ESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCHHHHCCH
VSDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGGPTMPMVPGTWAPARESSDEGR
HHHCCCCCCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNPWMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAEYRWVASEVEALLREVRSGGWQ
CCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCC
GQAVEMFVGSCMPFLAWLMKAAADYMDVATQQEVVAAAYAAAVEAMPTQFELAANRVVRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VLMATNFFGVNTIPIALNEEEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSN
HHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
VLVDDVEKDSRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVYP
CEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
GQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQLGTWLAEYPQL
CCHHHHHHHHHHHHHCHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVALGGTIANLGAVTGLAGLSSGLSAGPSAAIPTVVPESAPIATVPAMLAGAGVAPAVV
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEE
APGASPSSAAPPASAASAAAAAPAPPGTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVS
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHH
ESVSDSAVAEAAAQASAREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCHHHHCCH
VSDCGAGSFGFAGTVSKEAVVEVAGLTTLAGDDFGGGPTMPMVPGTWAPARESSDEGR
HHHCCCCCCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]