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The map label for this gene is pyrC

Identifier: 221229668

GI number: 221229668

Start: 646552

End: 647844

Strand: Direct

Name: pyrC

Synonym: MLBr_00533

Alternate gene names: 221229668

Gene position: 646552-647844 (Clockwise)

Preceding gene: 221229667

Following gene: 221229669

Centisome position: 19.78

GC content: 62.8

Gene sequence:

>1293_bases
ATGAGCGTGTTACTTCGTGGTGTCCGCTTGTATGGCGAGGGTGAACAAGTCGATGTACTGGTTGAGGGCGAGCAGATCGC
CAACATTGGTGCTGGTATTGATATTCCCGACACTGCTGATGTGATTGATGCCATCGATCAGGTGCTGCTGCCCGGCCTGG
TGGACCTGCACACCCACTTGCGCGAGCCGGGCCGCGAATATGCTGAGGACATCGAAACTGGTTCGGCAGCAGCGGCTCTT
GGTGGTTACACTGCGGTTTTCGCGATGCCCAATACCACCCCTGTAGCGGACAGTCCGGTGGTTACCGACCATGTCTGGCG
TCGTGGCCAGCAGGTCGGCCTGGTTGATGTGCACCCCGTCGGTGCGGTCACCGTCGGGCTGGCCGGAGCCGAGCTCACCG
AGATGGGTATGATGGCTGCCGGTGCCGCACAGGTGCGGATCTTCTCCGACGATGGCAACTGTGTGCATAACCCGTTGGTG
ATGCGCCGTGCCCTGGAGTACGCCACTGGCCTGGGGGTGCTGATCGCTCAGCACGCCGAGGAACCGAGGCTGACTGTCGG
CGCTGTTGCGCACGAGGGACCTACGGCCGCCAGGCTGGGATTGTCGGGATGGCCCAGAGCGGCCGAGGAATCAATTGTTG
CCCGCGACGCCCTGTTGGCCCGTGATGCCGGCGCTCGGGTGCACATCTGCCACGCTTCTACCGCAGGAACCGTAGAGATC
CTGAAATGGGCTAAAGAGCAAGGTATTTCGATAACTGCCGAGGTAACACCACATCATCTTTTGCTCGATGACAGCAGGTT
AGCCAGCTACGACGGGGTGAATCGGGTCAACCCGCCGCTGCGCGAAACCGCCGACGCAGTCGCACTGCGGCAGGCGTTGG
CTGATGGGATCATCGATTGTGTGACTACCGACCACGCCCCGCATGCCGATCATGAGAAGTGCGTCGAATTCTCCGCAGCG
CGCCCTGGCATGCTGGGCTTGCAGACGGCGCTGTCGGTGGTGGTGCACACGATGGTGGTGCCTGGCCTATTAAGCTGGCG
CGATGTCGCGCAGGTGATGAGTGAGAACCCTGCCCGCATCGCCGGGTTGCCCGATCATGGCCGGCCACTGGAGGTGGGTG
AACCGGCTAACCTGACGGTGGTGGACCCGGACGTTACCTGGACGGTCACCGGCGACGGCTTGGCCAGCAGGTCAGCCAAC
ACGCCGTACGAGGCGATGACCCTGCCCGCCACTGTGACTGCGACCCTGCTGCGCGGGAAGGTCACCGCCCGGGGTCAGAA
GAGTCCGGTATGA

Upstream 100 bases:

>100_bases
CAGCTGTTTTGCAACAGGTTTCCAACGGTGTGCATGTGCGGATGGCAGTGCTTTTCCATGTTCTGGTTGGGACCCAGTCG
GCCGAAGAAGAGGGTGCGGC

Downstream 100 bases:

>100_bases
ACTCTGGCACGCTGGTGGGGTCGCTGGTTGTCACGGCTCTGCTGGTGGTGTTGTGTTGCTGGCAGTGATAATTCAACTGA
TGATGTGTAGATGGCGGTGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAIDQVLLPGLVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLV
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
LKWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALRQALADGIIDCVTTDHAPHADHEKCVEFSAA
RPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARIAGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSAN
TPYEAMTLPATVTATLLRGKVTARGQKSPV

Sequences:

>Translated_430_residues
MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAIDQVLLPGLVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLV
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
LKWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALRQALADGIIDCVTTDHAPHADHEKCVEFSAA
RPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARIAGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSAN
TPYEAMTLPATVTATLLRGKVTARGQKSPV
>Mature_429_residues
SVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAIDQVLLPGLVDLHTHLREPGREYAEDIETGSAAAALG
GYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLVM
RRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEIL
KWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALRQALADGIIDCVTTDHAPHADHEKCVEFSAAR
PGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARIAGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSANT
PYEAMTLPATVTATLLRGKVTARGQKSPV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=403, Percent_Identity=31.5136476426799, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=25, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786722, Length=424, Percent_Identity=30.4245283018868, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI87082175, Length=435, Percent_Identity=25.7471264367816, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=375, Percent_Identity=31.4666666666667, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI86575075, Length=415, Percent_Identity=23.855421686747, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.6331658291457, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=383, Percent_Identity=30.8093994778068, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI18859883, Length=411, Percent_Identity=28.4671532846715, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_MYCLE (Q9CCR4)

Other databases:

- EMBL:   AL583918
- PIR:   E86975
- RefSeq:   NP_301453.1
- ProteinModelPortal:   Q9CCR4
- EnsemblBacteria:   EBMYCT00000028942
- GeneID:   909295
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0533
- NMPDR:   fig|272631.1.peg.325
- Leproma:   ML0533
- GeneTree:   EBGT00050000016208
- HOGENOM:   HBG724623
- OMA:   FAMANTH
- ProtClustDB:   PRK09357
- BioCyc:   MLEP272631:ML0533-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45187; Mature: 45056

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAIDQVLLPGLVDLHTHL
CCCEEEEEEEECCCCEEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPV
HCCHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHCCCEECEEEECCC
GAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLVMRRALEYATGLGVLIAQHAE
CEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCEECCHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
CCCEEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
LKWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALRQALADGIIDC
HHHHHHCCCEEEEECCCCEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VTTDHAPHADHEKCVEFSAARPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARI
HCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEE
AGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSANTPYEAMTLPATVTATLLRGK
ECCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHCC
VTARGQKSPV
CCCCCCCCCC
>Mature Secondary Structure 
SVLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDIPDTADVIDAIDQVLLPGLVDLHTHL
CCEEEEEEEECCCCEEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPV
HCCHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHCCCEECEEEECCC
GAVTVGLAGAELTEMGMMAAGAAQVRIFSDDGNCVHNPLVMRRALEYATGLGVLIAQHAE
CEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCEECCHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEI
CCCEEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
LKWAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALRQALADGIIDC
HHHHHHCCCEEEEECCCCEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VTTDHAPHADHEKCVEFSAARPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARI
HCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEE
AGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDGLASRSANTPYEAMTLPATVTATLLRGK
ECCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHCC
VTARGQKSPV
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002