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The map label for this gene is guaB2 [H]

Identifier: 221229592

GI number: 221229592

Start: 480670

End: 482259

Strand: Direct

Name: guaB2 [H]

Synonym: MLBr_00387

Alternate gene names: 221229592

Gene position: 480670-482259 (Clockwise)

Preceding gene: 221229590

Following gene: 221229593

Centisome position: 14.71

GC content: 62.58

Gene sequence:

>1590_bases
ATGATCCGTGGCATGTCCAACCTGAAAGAAAGCTCCGATTTCGTTGCCAGTTCGTACGTGCGCCTCGGTGGCCTGATGGA
CGACCCAGCCGCGACCGGGGGTGACAACCCACACAAGGTGGCCATGCTGGGGCTGACTTTCGACGATGTCCTGCTGTTGC
CTGCAGCTTCCGACGTGGTGCCTGCTACTGCAGACATTTCCAGTCAGCTGACCAAGAAGATCAGGCTCAAGGTGCCGTTG
GTCAGCTCAGCGATGGATACCGTCACCGAGGCACGGATGGCCATCGCCATGGCTCGGGCGGGCGGCATGGGCGTGCTGCA
CCGCAATCTGCCTGTTGGCGAACAGGCCGGACAGGTCGAGACGGTGAAGCGGTCTGAGGCTGGCATGGTTACTGATCCGG
TCACCTGCCGGCCGGACAACACCTTGGCCCAGGTTGGCGCGTTGTGCGCCCGGTTTCGGATCTCCGGGTTACCAGTGGTC
GACGATTCCGGTGCACTGGCTGGCATCATCACCAACCGCGACATGCGGTTCGAGGTCGACCAGTCCAAACAGGTCGCCGA
GGTGATGACCAAAACACCGCTGATCACAGCTGCTGAGGGTGTCAGCGCCGACGCGGCATTGGGTTTGTTGCGGCGAAATA
AGATCGAAAAGCTGCCCGTTGTCGACGGCCATGGCCGGCTGACCGGGCTGATCACTGTCAAAGACTTCGTTAAAACCGAG
CAGCACCCGCTGGCGACCAAGGACAACGATGGTCGGCTGCTGGTGGGTGCGGCCGTCGGTGTCGGCGGAGATGCCTGGGT
CCGCGCGATGATGTTGGTCGACGCTGGTGTCGACGTGCTGATCGTCGACACCGCGCACGCGCACAATCGGTTGGTGCTCG
ACATGGTCGGCAAACTCAAGGTCGAAATTGGCGACCGGGTCCAGGTGATTGGTGGCAATGTCGCTACCAGGTCGGCAGCG
GCAGCTTTGGTAGAGGCCGGCGCCGACGCGGTGAAGGTCGGCGTAGGGCCCGGGTCTACTTGCACGACCCGTGTGGTGGC
CGGTGTCGGCGCGCCGCAGATTACTGCGATCCTGGAGGCCGTCGCGGCGTGCGGACCGGCGGGCGTTCCTGTCATAGCCG
ACGGCGGGTTACAGTATTCCGGCGATATCGCCAAGGCGCTGGCCGCCGGCGCGTCGACGACCATGCTGGGTTCTTTGTTG
GCTGGCACTGCCGAGGCACCAGGCGAGTTGATCTTCGTCAATGGCAAGCAGTTCAAGAGCTATCGCGGCATGGGGTCGTT
GGGCGCCATGCAAGGTAGAGGTGGGGATAAGTCGTATTCCAAGGACCGCTATTTCGCCGACGACGCTTTGTCCGAGGACA
AGTTGGTCCCTGAGGGAATCGAGGGCAGGGTGCCGTTCCGTGGTCCGCTGTCGTCAGTGATCCACCAGCTGGTGGGTGGT
CTGCGCGCTGCGATGGGTTACACCGGCTCTCCTACCATCGAGGTGTTGCAGCAGGCACAGTTCGTCCGGATAACGCCCGC
CGGACTCAAAGAGAGCCACCCGCACGACGTTGCGATGACTGTCGAAGCCCCCAACTATTACCCGCGTTGA

Upstream 100 bases:

>100_bases
GTTTCATCACCGGCACAACACCCGGCCAAGCGAGCCCAGAGGATTGGTAAGCCTATAAGATGGGATTTCTCACTCCGCAT
GCATATGGAGGGCCGCACCG

Downstream 100 bases:

>100_bases
CGCCCGACATGGTCGAGATAGGGATGGGCCGCGTGGCCCGTCGAACATATGAGCTCCGTGAGATCAGCATCGTGCCGTCG
CGTCGCACTCGCTCGTCGAA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPL
VSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVV
DDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTE
QHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAA
AALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLL
AGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGG
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR

Sequences:

>Translated_529_residues
MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPL
VSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVV
DDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTE
QHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAA
AALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLL
AGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGG
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
>Mature_529_residues
MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVVPATADISSQLTKKIRLKVPL
VSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVV
DDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTE
QHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLKVEIGDRVQVIGGNVATRSAA
AALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLL
AGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGG
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=465, Percent_Identity=41.2903225806452, Blast_Score=329, Evalue=5e-90,
Organism=Homo sapiens, GI34328928, Length=465, Percent_Identity=41.2903225806452, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI156616279, Length=465, Percent_Identity=41.2903225806452, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI34328930, Length=465, Percent_Identity=41.2903225806452, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI66933016, Length=485, Percent_Identity=41.6494845360825, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI217035152, Length=460, Percent_Identity=41.0869565217391, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI217035148, Length=465, Percent_Identity=40.6451612903226, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI217035150, Length=465, Percent_Identity=39.1397849462366, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI50541956, Length=275, Percent_Identity=32.3636363636364, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI50541954, Length=275, Percent_Identity=32.3636363636364, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI50541952, Length=275, Percent_Identity=32.3636363636364, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI50541948, Length=275, Percent_Identity=32.3636363636364, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI156104880, Length=230, Percent_Identity=34.3478260869565, Blast_Score=133, Evalue=4e-31,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=54.2857142857143, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1786293, Length=239, Percent_Identity=33.4728033472803, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=483, Percent_Identity=35.6107660455487, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=443, Percent_Identity=36.568848758465, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=269, Percent_Identity=34.2007434944238, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323585, Length=459, Percent_Identity=40.5228758169935, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6322012, Length=459, Percent_Identity=39.2156862745098, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=459, Percent_Identity=39.8692810457516, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=37.4631268436578, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=41.3793103448276, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=40.3726708074534, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=40.3726708074534, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=39.5927601809955, Blast_Score=288, Evalue=6e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54815; Mature: 54815

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVV
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCC
PATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVE
CCCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCH
TVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDSGALAGIITNRDMRFEVD
HHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEEEC
QSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTE
CHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHCCC
QHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLK
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEE
VEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEA
EEECCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHH
VAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLLAGTAEAPGELIFVNGKQFKS
HHHCCCCCCCEEECCCCEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHH
YRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGG
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
HHHHHCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MIRGMSNLKESSDFVASSYVRLGGLMDDPAATGGDNPHKVAMLGLTFDDVLLLPAASDVV
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCC
PATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIAMARAGGMGVLHRNLPVGEQAGQVE
CCCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCH
TVKRSEAGMVTDPVTCRPDNTLAQVGALCARFRISGLPVVDDSGALAGIITNRDMRFEVD
HHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEEEC
QSKQVAEVMTKTPLITAAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTE
CHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHCCC
QHPLATKDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMVGKLK
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEE
VEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVVAGVGAPQITAILEA
EEECCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHH
VAACGPAGVPVIADGGLQYSGDIAKALAAGASTTMLGSLLAGTAEAPGELIFVNGKQFKS
HHHCCCCCCCEEECCCCEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHH
YRGMGSLGAMQGRGGDKSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGG
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
HHHHHCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]